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Original Article

Efficacy of prolonged release melatonin in insomnia patients aged 55–80 years: quality of sleep and next-day alertness outcomes

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Pages 2597-2605 | Accepted 03 Aug 2007, Published online: 14 Sep 2007

References

  • Dement WC, Miles LE, Carskadon MA. ‘White paper’ on sleep and aging. J Am Geriatr Soc 1982;30:25–50
  • Buysse DJ, Reynolds CF, 3rd, Monk TH, et al. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 1989;28: 193–213
  • Hajak G. Epidemiology of severe insomnia and its consequences in Germany. Eur Arch Psychiatry Clin Neurosci 2001;251:49–56
  • Zeitlhofer J, Schmeiser-Rieder A, Tribl G, et al. Sleep and quality of life in the Austrian population. Acta Neurol Scand 2000;102:249–57
  • Riemann D, Voderholzer U, Berger M. Non-restorative sleep and insomnia. Diagnostic and therapeutic options for psychiatry and psychotherapy [in German]. Nervenarzt 2003;74:450–67; quiz 468–9
  • Zammit GK, Weiner J, Damato N, et al. Quality of life in people with insomnia. Sleep 1999;22(Suppl 2):S379–85
  • Pilcher JJ, Ginter DR, Sadowsky B. Sleep quality versus sleep quantity: relationships between sleep and measures of health, well-being and sleepiness in college students. J Psychosom Res 1997;42:583–96
  • Ohayon MM. Prevalence and correlates of nonrestorative sleep complaints. Arch Intern Med 2005;165:35–41
  • Krystal AD. Treating the health, quality of life, and functional impairments in insomnia. J Clin Sleep Med 2007;3:63–72
  • Morin CM. Measuring outcomes in randomized clinical trials of insomnia treatments. Sleep Med Rev 2003;7:263–79
  • Glass J, Lanctot KL, Herrmann N, et al. Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits. BMJ 2005;331:1169
  • Landolt H, Gillin JC. GABA(A1A) receptors: involvement in sleep regulation and potential of selective agonists in the treatment of insomnia. CNS Drugs 2000;13:185–99
  • Brzezinski A. Melatonin in humans. N Engl J Med 1997;336:186–95
  • Nakagawa H, Sack RL, Lewy AJ. Sleep propensity free-runs with the temperature, melatonin and cortisol rhythms in a totally blind person. Sleep 1992;15:330–6
  • Lockley SW, Skene DJ, Tabandeh H, et al. Relationship between napping and melatonin in the blind. J Biol Rhythms 1997;12:16–25
  • Cajochen C, Krauchi K, Wirz-Justice A. Role of melatonin in the regulation of human circadian rhythms and sleep. J Neuroendocrinol 2003;15:432–7
  • Wyatt JK, Dijk DJ, Ritz-de Cecco A, et al. Sleep-facilitating effect of exogenous melatonin in healthy young men and women is circadian-phase dependent. Sleep 2006;29:609–18
  • Liu C, Weaver DR, Jin X, et al. Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock. Neuron 1997;19:91–102
  • Shochat T, Luboshitzky R, Lavie P. Nocturnal melatonin onset is phase locked to the primary sleep gate. Am J Physiol 1997;273:R364–70
  • Gorfine T, Assaf Y, Goshen-Gottstein Y, et al. Sleep-anticipating effects of melatonin in the human brain. Neuroimage 2006;31:410–8
  • Gorfine T, Zisapel N. Melatonin and the human hippocampus, a time dependant interplay. J Pineal Res 2007;43:80–6
  • Sharma M, Palacios-Bois J, Schwartz G, et al. Circadian rhythms of melatonin and cortisol in aging. Biol Psychiatry 1989;25:305–19
  • Haimov I, Laudon M, Zisapel N, et al. Sleep disorders and melatonin rhythms in elderly people. BMJ 1994;309:167
  • Hajak G, Rodenbeck, A, Staedt J, et al. Nocturnal plasma melatonin levels in patients suffering from chronic primary insomnia. J Pineal Res 1996;19:116–122
  • Leger D, Laudon M, Zisapel N. Nocturnal 6-sulfatoxymelatonin excretion in insomnia and its relation to the response to melatonin replacement therapy. Am J Med 2004;116: 91–5
  • Buscemi N, Vandermeer B, Hooton N, et al. The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis. J Gen Intern Med 2005;20:1151–8
  • Parrott AC, Hindmarch I. The Leeds Sleep Evaluation Questionnaire in psychopharmacological investigations – a review. Psychopharmacology (Berl) 1980;71:173–9
  • Zisapel N, Laudon M. Subjective assessment of the effects of CNS-active drugs on sleep by the Leeds sleep evaluation questionnaire: a review. Hum Psychopharmacol 2003;18:1–20
  • Parrott AC, Hindmarch I. Factor analysis of a sleep evaluation questionnaire. Psychol Med 1978;8:325–9
  • Tarrasch R, Laudon M, Zisapel N. Cross-cultural validation of the Leeds sleep evaluation questionnaire (LSEQ) in insomnia patients. Hum Psychopharmacol 2003;18:603–10
  • Rombaut N; Maillard F, Kelly FI. The quality of life of insomniacs questionnaire (QOLI). Med Sci Res 1990;18:845–7
  • Kieser M, Rohmel J, Friede T. Power and sample size determination when assessing the clinical relevance of trial results by ‘responder analyses’. Stat Med 2004;23:3287–305
  • Zisapel N, Nir T. Determination of the minimal clinically significant difference on a patient visual analog sleep quality scale. J Sleep Res 2003;12:291–8
  • Assocation WP. The management of insomnia, guidelines for clinical practice, 1991
  • Chesson A Jr, Hartse K, Anderson WM, et al. Practice parameters for the evaluation of chronic insomnia. An American Academy of Sleep Medicine report. Standards of Practice Committee of the American Academy of Sleep Medicine. Sleep 2000;23:237–41
  • Buysse DJ, Ancoli-Israel S, Edinger JD, et al. Recommendations for a standard research assessment of insomnia. Sleep 2006;29:1155–73
  • Backhaus J, Junghanns K, Broocks A, et al. Test-retest reliability and validity of the Pittsburgh Sleep Quality Index in primary insomnia. J Psychosom Res 2002;53:737–40
  • Guy W. ECDEU assessment manual for psychopharmacology (rev., 1976). Biometric Laboratory. The George Washington University, Kensington, Maryland, US, 1976
  • Bech P, Olsen LR, Kjoller M, et al. Measuring well-being rather than the absence of distress symptoms: a comparison of the SF-36 Mental Health subscale and the WHO-Five Well-Being Scale. Int J Methods Psychiatr Res 2003;12:85–91
  • Ancoli-Israel S, Walsh JK, Mangano RM, et al. Zaleplon, A novel nonbenzodiazepine hypnotic, effectively treats insomnia in elderly patients without causing rebound effects. Prim Care Companion J Clin Psychiatry 1999;1:114–20
  • Maquet P. Sleep function(s) and cerebral metabolism. Behav Brain Res 1995;69:75–83
  • Roth T, Seiden D, Sainati S, et al. Effects of ramelteon on patient-reported sleep latency in older adults with chronic insomnia. Sleep Med 2006;7:312–8
  • Otmani S, Staner C, Jacob N, et al. Effects of prolonged-release melatonin, zolpidem and their combination on psychomotor functions, memory recall and driving skills in healthy middle aged and elderly volunteers. J Sleep Medicine 2007 [submitted]

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