145
Views
7
CrossRef citations to date
0
Altmetric
Original Article

Achieving BP goals with valsartan and HCTZ alone and in combination: pooled analysis of two randomized, double-blind, placebo-controlled studies

, &
Pages 2617-2626 | Accepted 09 Jul 2008, Published online: 06 Aug 2008

References

  • Chobanian AV, Bakris GL, Black HR. et al. and the National High Blood Pressure Education Program Coordinating Committee. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension 2003;42:1206-521Chobanian AV, Bakris GL, Black HR. et al. and the National High Blood Pressure Education Program Coordinating Committee. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension 2003;42:1206-52
  • ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002;288:2981–97.2ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002;288:2981–97.
  • Sharma AM, Engeli S. Managing big issues on lean evidence: treating obesity hypertension. Nephrol Dial Transplant 2002; 17:353–53Sharma AM, Engeli S. Managing big issues on lean evidence: treating obesity hypertension. Nephrol Dial Transplant 2002; 17:353–5
  • Sica DA. Rationale for fixed-dose combinations in the treatment of hypertension: the cycle repeats. Drugs 2002;62:443–624Sica DA. Rationale for fixed-dose combinations in the treatment of hypertension: the cycle repeats. Drugs 2002;62:443–62
  • Weber MA. Creating a combination antihypertensive regimen: what does the research show? J Cin Hypertens (Greenwich) 2003;5(Suppl 3)::12–205Weber MA. Creating a combination antihypertensive regimen: what does the research show? J Cin Hypertens (Greenwich) 2003;5(Suppl 3)::12–20
  • Mallion J-M, Carretta R, Trenkwalder P. et al. on behalf of the Co-Diovan Study Group. Valsartan/hydrocholorothiazide is effective in hypertensive patients inadequately controlled by valsartan monotherapy. Blood Press 2003;12(Suppl 1):36-436Mallion J-M, Carretta R, Trenkwalder P. et al. on behalf of the Co-Diovan Study Group. Valsartan/hydrocholorothiazide is effective in hypertensive patients inadequately controlled by valsartan monotherapy. Blood Press 2003;12(Suppl 1):36-43
  • Lacourcière Y, Poirier L, Hebert D. et al. Antihypertensive efficacy and tolerability of two fixed-dose combinations of valsartan and hydrochlorothiazide compared with valsartan monotherapy in patients with stage 2 or 3 systolic hypertension: an 8-week, randomized, double-blind, parallel-group trial. Clin Ther 2005; 27:1013–217Lacourcière Y, Poirier L, Hebert D. et al. Antihypertensive efficacy and tolerability of two fixed-dose combinations of valsartan and hydrochlorothiazide compared with valsartan monotherapy in patients with stage 2 or 3 systolic hypertension: an 8-week, randomized, double-blind, parallel-group trial. Clin Ther 2005; 27:1013–21
  • Mimran A, Weir MR. Angiotensin-receptor blockers and diuretics: advantages of combination. Blood Press 2005;14:6–118Mimran A, Weir MR. Angiotensin-receptor blockers and diuretics: advantages of combination. Blood Press 2005;14:6–11
  • Palatini P. Combination therapy in the management of hypertension: focus on angiotensin receptor blockers combined with diuretics. J Clin Hypertens (Greenwich) 2005;7:96–1019Palatini P. Combination therapy in the management of hypertension: focus on angiotensin receptor blockers combined with diuretics. J Clin Hypertens (Greenwich) 2005;7:96–101
  • Benz JR, Black HR, Graff A. et al. Valsartan and hydrochlorothiazide in patients with essential hypertension: a multiple dose, double-blind, placebo controlled trial comparing combination therapy with monotherapy. J Hum Hypertens 1998; 12: 861–6610Benz JR, Black HR, Graff A. et al. Valsartan and hydrochlorothiazide in patients with essential hypertension: a multiple dose, double-blind, placebo controlled trial comparing combination therapy with monotherapy. J Hum Hypertens 1998; 12: 861–66
  • Zillich AJ, Garg J, Basu S. et al. Thiazide diuretics, potassium, and the development of diabetes: a quantitative review. Hypertension 2006;48:219–2411Zillich AJ, Garg J, Basu S. et al. Thiazide diuretics, potassium, and the development of diabetes: a quantitative review. Hypertension 2006;48:219–24
  • Pool JL, Glazer R, Weinberger M. et al. Comparison of valsartan/hydrochlorothiazide combination therapy at doses up to 320/25 mg versus monotherapy: a double-blind, placebo-controlled study followed by long-term combination therapy in hypertensive adults. Clin Ther 2007;29:61–7312Pool JL, Glazer R, Weinberger M. et al. Comparison of valsartan/hydrochlorothiazide combination therapy at doses up to 320/25 mg versus monotherapy: a double-blind, placebo-controlled study followed by long-term combination therapy in hypertensive adults. Clin Ther 2007;29:61–73
  • Harrell FE. Regression modeling strategies with applications to linear models, logistic regression, and survival analysis. New York: Springer, 200113Harrell FE. Regression modeling strategies with applications to linear models, logistic regression, and survival analysis. New York: Springer, 2001
  • Faraway JJ. On the cost of data analysis. J Computational and Graphical Statistics 1992;1:213–2914Faraway JJ. On the cost of data analysis. J Computational and Graphical Statistics 1992;1:213–29
  • Moyé LA. Statistical reasoning in medicine: the intuitive p value primer. New York: Springer, 200015Moyé LA. Statistical reasoning in medicine: the intuitive p value primer. New York: Springer, 2000
  • Poole C. Beyond the confidence interval. Am J Public Health 1987;77:195–9916Poole C. Beyond the confidence interval. Am J Public Health 1987;77:195–99
  • Gardner MJ, Altman DG. Confidence intervals rather than p values: estimation rather than hypothesis testing. BMJ 1986; 292:746–5017Gardner MJ, Altman DG. Confidence intervals rather than p values: estimation rather than hypothesis testing. BMJ 1986; 292:746–50
  • Lang JM, Rothman KJ, Cann CI. That confounded p-value. Epidemiology 1998;9:7–818Lang JM, Rothman KJ, Cann CI. That confounded p-value. Epidemiology 1998;9:7–8
  • Van Belle G. Statistical rules of thumb. Wiley series in probability and statistics. New York: John Wiley & Sons, 200219Van Belle G. Statistical rules of thumb. Wiley series in probability and statistics. New York: John Wiley & Sons, 2002
  • Basile JN, Chrysant S. The importance of early antihypertensive efficacy: the role of angiotensin II receptor blocker therapy. J Hum Hypertens 2006;20:169–7520Basile JN, Chrysant S. The importance of early antihypertensive efficacy: the role of angiotensin II receptor blocker therapy. J Hum Hypertens 2006;20:169–75
  • Staessen JA, Thijs L, Fagard R. et al. for the Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Effects of immediate versus delayed antihypertensive therapy on outcome in the Systolic Hypertension in Europe trial. J Hypertens 2004;22:847-5721Staessen JA, Thijs L, Fagard R. et al. for the Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Effects of immediate versus delayed antihypertensive therapy on outcome in the Systolic Hypertension in Europe trial. J Hypertens 2004;22:847-57
  • Caro JJ, Salas M, Speckman JL. et al. Persistence with treatment for hypertension in actual practice. CMAJ 1999; 160:31–722Caro JJ, Salas M, Speckman JL. et al. Persistence with treatment for hypertension in actual practice. CMAJ 1999; 160:31–7
  • Caro JJ, Speckman JL, Salas M. et al. Effect of initial drug choice on persistence with antihypertensive therapy: the importance of actual practice data. CMAJ 1999;160:41–623Caro JJ, Speckman JL, Salas M. et al. Effect of initial drug choice on persistence with antihypertensive therapy: the importance of actual practice data. CMAJ 1999;160:41–6
  • Payne KA, Esmonde-White S. Observational studies of antihypertensive medication use and compliance: is drug choice a factor in treatment adherence? Curr Hypertens Rep 2000; 2:515–2424Payne KA, Esmonde-White S. Observational studies of antihypertensive medication use and compliance: is drug choice a factor in treatment adherence? Curr Hypertens Rep 2000; 2:515–24

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.