95
Views
2
CrossRef citations to date
0
Altmetric
Original Article

Sustained effects in hypercholesterolaemic patients on combined simvastatin/ezetimibe treatment: observational cohort study in clinical practice

, , , &
Pages 2777-2784 | Accepted 31 Jul 2008, Published online: 21 Aug 2008

References

  • Law MR, Wald NJ, Rudnicka AR. Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis. Br Med J 2003; 326:1423-30
  • Grundy SM, Cleeman JI, Merz CN,. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 2004; 110:227-39
  • Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). J Am Med Ass 2001;285:2486-97
  • Silber S, Jarre F, Pittrow D, et al. Cardiovascular risk assessment in primary care (DETECT): what is the concordance between physician assessment and established risk scores? [Article in German]. Medizinische Klinik. 2008 (in press)
  • Jones P, Kafonek S, Laurora I,. Comparative dose efficacy study of atorvastatin versus simvastatin, pravastatin, lovastatin, and fluvastatin in patients with hypercholesterolemia (the CURVES study). Am J Cardiol 1998;81:582-7
  • Pedersen TR, Faergeman O, Kastelein JJP,. High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: the IDEAL study: a randomized controlled trial. JAMA 2005;294:2437-45
  • DeLemos J, Blazine M, Wiviott S,. Early intensive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes: phase Z of the A to Z trial. JAMA 2004;292:1307-16
  • McKenney JM. Optimizing LDL-C lowering with statins. Am J Ther 2004;11:54-9
  • Jackevicius CA, Tu JV, Ross JS,. Use of ezetimibe in the United States and Canada. N Engl J Med 2008;358:1819-28
  • Toth PP, Davidson MH. Simvastatin plus ezetimibe: combination therapy for the management of dyslipidaemia. Expert Opin Pharmacother 2005;6:131-9
  • Pearson TA, Laurora I, Chu H,. The lipid treatment assessment project (L-TAP): a multicenter survey to evaluate the percentages of dyslipidemic patients receiving lipid-lowering therapy and achieving low-density lipoprotein cholesterol goals. Arch Intern Med 2000;160:459-67
  • McBride P, Schrott HG, Plane MB,. Primary care practice adherence to National Cholesterol Education Program guidelines for patients with coronary heart disease. Arch Intern Med 1998;158:1238-44
  • Assmann G, Benecke H, Neiss A,. Gap between guidelines and practice: attainment of treatment targets in patients with primary hypercholesterolemia starting statin therapy. Results of the 4E-Registry (Efficacy Calculation and Measurement of Cardiovascular and Cerebrovascular Events Including Physicians’ Experience and Evaluation). Eur J Cardiovasc Prev Rehabil 2006;13:776-83
  • Edwards IR, Aronson JK. Adverse drug reactions: definitions, diagnosis, and management. Lancet 2000;356:1255-9
  • Hildemann SK, Barho C, Karmann B,. Dual cholesterol inhibition with ezetimibe/simvastatin in pre-treated hypercholesterolaemic patients with coronary heart disease or diabetes mellitus: prospective observational cohort studies in clinical practice. Curr Med Res Opin 2007;23:713-19
  • Hildemann S, Karmann B, Pittrow D,. Predictors of uncontrolled hyperlipidaemia in high-risk ambulatory patients in primary care. Curr Med Res Opin 2008;24:1659-68
  • Farnier M, Volpe M, Massaad R,. Effect of co-administering ezetimibe with on-going simvastatin treatment on LDL-C goal attainment in hypercholesterolemic patients with coronary heart disease. Int J Cardiol 2005;102:327-32
  • Brohet C, Banai S, Alings AM,. LDL-C goal attainment with the addition of ezetimibe to ongoing simvastatin treatment in coronary heart disease patients with hypercholesterolemia. Curr Med Res Opin 2005;21:571-8
  • Pearson TA, Denke MA, McBride PE,. A community-based, randomized trial of ezetimibe added to statin therapy to attain NCEP ATP III goals for LDL cholesterol in hypercholesterolemic patients: the ezetimibe add-on to statin for effectiveness (EASE) trial. Mayo Clin Proc 2005; 80:587-95
  • Mikhailidis DP, Sibbring GC, Ballantyne CM,. Meta-analysis of the cholesterol-lowering effect of ezetimibe added to ongoing statin therapy. Curr Med Res Opin 2007; 23:2009-26
  • Daskalopoulou SS, Mikhailidis DP. Reaching goal in hypercholesterolaemia: dual inhibition of cholesterol synthesis and absorption with simvastatin plus ezetimibe. Curr Med Res Opin 2006;22:511-28
  • Kastelein JJ, Akdim F, Stroes ES,. Simvastatin with or without ezetimibe in familial hypercholesterolemia. N Engl J Med 2008;358:1431-43
  • CASHMERE Study Group. Carotid atorvastatin study in hyperlipidemic post-menopausal women: a randomised evaluation of atorvastatin versus placebo (www.clintrials.gov, trial identifier NCT00163163, TrialTrove ID-034363. Accessed on 27 July 2008
  • Drazen JM, Jarcho JA, Morrissey S,. Cholesterol lowering and ezetimibe. N Engl J Med 2008;358:1507-8
  • Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II). JAMA 1993;269:3015-23
  • Krauss RM, Eckel RH, Howard B,. AHA Dietary Guidelines: Revision 2000: A Statement for Healthcare Professionals From the Nutrition Committee of the American Heart Association. Circulation 2000;102:2284-99
  • Pittrow D, Pieper L, Klotsche J, et al., eds. DETECT. Ergebnisse einer klinisch-epidemiologischen Querschnitts- und Verlaufsstudie mit 50.000 Patienten in 3.000 Hausarztpraxen. München: Elsevier, Oktober 2007
  • Fernandez R, Griffiths R, Everett B,. Effectiveness of brief structured interventions on risk factor modification for patients with coronary heart disease: a systematic review. Int J Evidence-Based Healthcare 2007;5:370-405
  • Twardella D, Merx H, Hahmann H,. Long term adherence to dietary recommendations after inpatient rehabilitation: prospective follow up study of patients with coronary heart disease. Heart 2006;92:635-40
  • Committee of Safety of Medicines. Adverse reactions working party: second report. London: HMSO, 1986
  • Laupacis A, Mamdani M. Observational studies of treatment effectiveness: some cautions. Ann Intern Med 2004;140:923-4
  • Concato J, Shah N, Horwitz RI. Randomized, controlled trials, observational studies, and the hierarchy of research designs. N Engl J Med 2000;342:1887-92
  • Kristman V, Manno M Cote P. Loss to follow-up in cohort studies: how much is too much? Eur J Epidemiol 2004; 19:751-60
  • Cheng CW, Woo KS, Chan JC, ., Assessing adherence to statin therapy using patient report, pill count, and an electronic monitoring device. Am J Health Syst Pharm 2005; 62:411-15

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.