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Review

Cost-effectiveness of venous thromboembolism prophylaxis in total hip and knee replacement surgery: the evolving application of health economic modelling over 20 years

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Pages 2993-3006 | Accepted 01 Sep 2008, Published online: 02 Oct 2008

References

  • Weinstein MC, O’Brien B, Hornberger J, et al., and the ISPOR Task Force on Good Research Practices – Modeling Studies. Principles of good practice for decision analytic modeling in health-care evaluation: report of the ISPOR Task Force on Good Research Practices – Modeling StudiesValue Health 2003;6:9-17
  • Briggs A, Sculpher M. Claxton K. Decision Modelling for Health Economic Evaluation (Handbooks for Health Economic Evaluations). : Oxford University PressOxford, 2006
  • Ades AE, Sculpher M, Sutton A,. et al.Bayesian methods for evidence synthesis in cost-effectiveness analysis. Pharmacoeconomics 2006;24:1-19
  • Geerts WH, Pineo GF, Heit JA,. et al.Prevention of venous thromboembolism: the seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004; 126(Suppl 3): 338-400S
  • Prandoni P, Lensing AW, Prins MR. Long-term outcomes after deep venous thrombosis of the lower extremities. Vasc Med 1998; 3:57-60
  • Oster G, Tuden RL, Colditz GA. A cost-effectiveness analysis of prophylaxis against deep-vein thrombosis in major orthopedic surgery. JAMA 1987;257:203-8
  • Sullivan SD, Kahn SR, Davidson BL,. et al.Measuring the outcomes and pharmacoeconomic consequences of venous thromboembolism prophylaxis in major orthopaedic surgery. Pharmacoeconomics 2003;21:477-96
  • National Institute for Health and Clinical Excellence website: http://www.nice.org.uk/ [Last accessed 31 March 2008]
  • Canadian Agency for Drugs and Technologies in Health website: http://www.cadth.ca/ [Last accessed 31 March 2008]
  • Scottish Medicines Consortium website: http://www. scottishmedicines.org.uk/ [Last accessed 31 March 2008]
  • Drummond M, Aristides M, Davies L,. et al.Economic evaluation of standard heparin and enoxaparin for prophylaxis against deep vein thrombosis after total hip replacement surgery. Br J Surg 1994;81:1742-6
  • O’Brien BJ, Anderson DR, Goeree R. Cost-effectiveness of enoxaparin versus warfarin prophylaxis against deep-vein thrombosis after total hip replacement. CMAJ 1994;150: 1083-90
  • Menzin J, Colditz GA, Regan MM,. et al.Cost-effectiveness of enoxaparin vs low-dose warfarin in the prevention of deep-vein thrombosis after total hip replacement surgery. Arch Intern Med 1995;155:757-64
  • Borris LC, Lassen MR. Thromboprophylaxis with low molecular weight heparin after major orthopaedic surgery is cost effective. Drugs 1996;52(Suppl 7):42-6
  • Abdool-Carrim T, Adler H, Becker P, . et al.The cost and benefit of prophylaxis against deep vein thrombosis in elective hip replacement. DVT/PE Prophylaxis Consensus Forum. S Afr Med J 1997;87:594-600
  • Hawkins DW, Langley PC, Krueger KP. Pharmacoeconomic model of enoxaparin versus heparin for prevention of deep vein thrombosis after total hip replacement. Am J Health Syst Pharm 1997;54:1185-90
  • Levin LA, Horst M, Bergqvist D. Economic evaluation of desirudin vs heparin in deep vein thrombosis prevention after hip replacement surgery. Pharmacoeconomics 1998;13(1 pt 2): 111-18
  • Anderson DR, O’Brien B, Nagpal S. Economic evaluation comparing low molecular weight heparin with other modalities for the prevention of deep vein thrombosis and pulmonary embolism following total hip or knee arthroplasty. Ottawa: Canadian Coordinating Office for Health Technology Assessment, 1998
  • Detournay B, Planes A, Vochelle N,. et al.Cost effectiveness of a low-molecular-weight heparin in prolonged prophylaxis against deep vein thrombosis after total hip replacement. Pharmacoeconomics 1998;13(1 pt 1):81-9
  • Hawkins DW, Langley PC, Krueger KP. A pharmacoeconomic assessment of enoxaparin and warfarin as prophylaxis for deep vein thrombosis in patients undergoing knee replacement surgery. Clin Ther 1998;20:182-95
  • Nicolaides A, Bosanquet N. Cost-effectiveness of desirudin in the prevention of the thromboembolic complications of surgery. J Med Econ 1999;2:155-66
  • Marchetti M, Liberato NL, Ruperto N,. et al.Long-term cost-effectiveness of low molecular weight heparin versus unfractionated heparin for the prophylaxis of venous thromboembolism in elective hip replacement. Haematologica 1999;84:730-7
  • Davies LM, Richardson GA, Cohen AT. Economic evaluation of enoxaparin as postdischarge prophylaxis for deep vein thrombosis (DVT) in elective hip surgery. Value Health 2000; 3:397-406
  • Levin LA, Bergqvist D. Cost effectiveness of desirudin compared with a low molecular weight heparin in the prevention of deep vein thrombosis after total hip replacement surgery. Pharmacoeconomics 2001;19(5 pt 2):589-97
  • Botteman MF, Caprini J, Stephens JM,. et al.Results of an economic model to assess the cost-effectiveness of enoxaparin, a low-molecular-weight heparin, versus warfarin for the prophylaxis of deep vein thrombosis and associated long-term complications in total hip replacement surgery in the United States. Clin Ther 2002;24:1960-86
  • Sarasin FP, Bounameaux H. Out of hospital antithrombotic prophylaxis after total hip replacement: low-molecular-weight heparin, warfarin, aspirin or nothing? A cost-effectiveness analysis. Thromb Haemost 2002;87:586-92
  • Nerurkar J, Wade WE, Martin BC. Cost/death averted with venous thromboembolism prophylaxis in patients undergoing total knee replacement or knee arthroplasty. Pharmacotherapy 2002;22:990-1000
  • Gordois A, Posnett J, Borris L,. et al.The cost-effectiveness of fondaparinux compared with enoxaparin as prophylaxis against thromboembolism following major orthopedic surgery. J Thromb Haemost 2003;1:2167-74
  • Lundkvist J, Bergqvist D, Jonsson B. Cost-effectiveness of fondaparinux vs. enoxaparin as venous thromboembolism prophylaxis in Sweden. Eur J Health Econ 2003;4:254-62
  • Honorato J, Gomez-Outes A, Navarro-Quilis A,. et al.Pharmacoeconomic analysis of bemiparin and enoxaparin as prophylaxis for venous thromboembolism in total knee replacement surgery. Pharmacoeconomics 2004;22:885-94
  • Annemans L, Minjoulat-Rey MC, De KM,. et al.Cost consequence analysis of fondaparinux versus enoxaparin in the prevention of venous thromboembolism after major orthopaedic surgery in Belgium. Acta Clin Belg 2004;59:346-57
  • Sullivan SD, Davidson BL, Kahn SR,. et al.A cost-effectiveness analysis of fondaparinux sodium compared with enoxaparin sodium as prophylaxis against venous thromboembolism: use in patients undergoing major orthopaedic surgery. Pharmacoeconomics 2004;22:605-20
  • Haentjens P, De GK, Annemans L. Prolonged enoxaparin therapy to prevent venous thromboembolism after primary hip or knee replacement. A cost-utility analysis. Arch Orthop Trauma Surg 2004;124:507-17
  • Bjorvatn A, Kristiansen F. Fondaparinux sodium compared with enoxaparin sodium: a cost-effectiveness analysis. Am J Cardiovasc Drugs 2005;5:121-30
  • Olsen J, Gundgaard J, Borris LC. The cost-effectiveness of fondaparinux compared to enoxaparin as prophylaxis for deep-vein thrombosis in Denmark. Ugeskr Laeger 2005;167:2273-9
  • Szucs TD, Kaiser WE, Mahler F,. et al.Thromboembolic prophylaxis with fondaparinux in major orthopaedic surgery: outcomes and costs. Heart Drug 2005;5:121-30
  • Bischof M, Leuppi JD, Sendi P. Cost-effectiveness of extended venous thromboembolism prophylaxis with fondaparinux in hip surgery patients. Expert Rev Pharmacoecon Outcomes Res 2006;6:171-80
  • Venous thromboembolism. Reducing the risk of venous thromboembolism (deep vein thrombosis and pulmonary embolism) in inpatients undergoing surgery, London: National Collaborating Centre for Acute Care, 2007. Available at: http://www.rcseng.ac.uk/surgical_research_units/nccac/guidelines/venous_thrombo_guideline.html [Last accessed 1 April 2008]
  • Spruill WJ, Wade WE, Leslie RB. Cost analysis of fondaparinux versus enoxaparin as venous thromboembolism prophylaxis in elective hip replacement surgery. Blood Coagul Fibrinolysis 2004;15:539-43
  • Spruill WJ, Wade WE, Leslie RB. A cost analysis of fondaparinux versus enoxaparin in total knee arthroplasty. Am J Ther 2004;11:3-8
  • Posnett J, Gordois A. Cost-effectiveness of fondaparinux vs enoxaparin as prophylaxis against venous thromboembolism following orthopedic surgery [abstract]. Value Health 2002; 5:444
  • Prandoni P, Villalta S, Bagatella P,. et al.The clinical course of deep-vein thrombosis. Prospective long-term follow-up of 528 symptomatic patients. Haematologica 1997;82:423-8
  • Almeida JI, Coats R, Liem TK,. et al.Reduced morbidity and mortality rates of the heparin-induced thrombocytopenia syndrome. J Vasc Surg 1998;27:309-14
  • 3rd annual clinical report. Hemel Hempstead: UK National Joint Registry for England and Wales, 2005. Available at: http://www.njrcentre.org.uk/documents/reports/annual/3rd/NJR_AR2_LR.pdf [Last accessed 10 July 2007]
  • Anderson FA Jr, Hirsh J, White K, Fitzgerald RH Jr, and the Hip and Knee Registry Investigators. Temporal trends in prevention of venous thromboembolism following primary total hip or knee arthroplasty 1996-2001: findings from the Hip and Knee Registry. Chest 2003;124( Suppl 6):349-56S
  • Bell GK, Goldhaber SZ. Cost implications of low molecular weight heparins as prophylaxis following total hip and knee replacement. Vasc Med 2001;6:23-9
  • Ouriel K, Kaul AF, Leonard MC. Clinical and economic outcomes in thrombolytic treatment of peripheral arterial occlusive disease and deep venous thrombosis. J Vasc Surg 2004;40:971-7
  • Pellegrini Jr VD, Clement D, Lush-Ehmann C,. et al.The John Charnley Award: natural history of thromboembolic disease after total hip arthroplasty. Clin Orthop Relat Res 1996;333: 27-40
  • Elting LS, Escalante CP, Cooksley C,. et al.Outcomes and cost of deep venous thrombosis among patients with cancer. Arch Intern Med 2004;164:1653-61
  • Garabedian-Ruffalo SM, Gray DR, Sax MJ,. et al.Retrospective evaluation of a pharmacist-managed warfarin anticoagulation clinic. Am J Hosp Pharm 1985;42:304-8
  • Hull RD, Pineo GF, Raskob GE. The economic impact of treating deep vein thrombosis with low-molecular-weight heparin: outcome of therapy and health economy aspects. Haemostasis 1998;28(Suppl 3):8-16
  • Hamby L, Weeks WB, Malikowski C. Complications of warfarin therapy: causes, costs, and the role of the anticoagulation clinic. Eff Clin Pract 2000;3:179-84
  • Anderson DR, O’Brien BJ, Levine MN,. et al.Efficacy and cost of low-molecular-weight heparin compared with standard heparin for the prevention of deep vein thrombosis after total hip arthroplasty. Ann Intern Med 1993;119:1105-12
  • Dranitsaris G, Kahn SR, Stumpo C,. et al.Pharmacoeconomic analysis of fondaparinux versus enoxaparin for the prevention of thromboembolic events in orthopedic surgery patients. Am J Cardiovasc Drugs 2004;4:325-33
  • Hull RD, Pineo GF, Francis C,. et al.Low-molecular-weight heparin prophylaxis using dalteparin extended out-of-hospital vs in-hospital warfarin/out-of-hospital placebo in hip arthroplasty patients: a double-blind, randomized comparison. North American Fragmin Trial Investigators. Arch Intern Med 2000;160:2208-15
  • Colwell Jr CW, Pulido P, Hardwick ME,. et al.Patient compliance with outpatient prophylaxis: an observational study. Orthopedics 2005;28:143-7
  • Spahn G. Compliance with self-administration of heparin injections in outpatients. Eur J Trauma 2002;28:104-9
  • Spyropoulos AC. Outpatient protocols for treatment of venous thromboembolism using low-molecular-weight heparin: to treat or not to treat at home. Arch Intern Med 1999;159:1139-40
  • Yusen RD, Haraden BM, Gage BF,. et al.Criteria for outpatient management of proximal lower extremity deep venous thrombosis. Chest 1999;115:972-9
  • Bergqvist D, Jonsson B. Cost-effectiveness of prolonged out-of-hospital prophylaxis with low-molecular-weight heparin following total hip replacement. Haemostasis 2000;30(Suppl 2): 130-5
  • Backman K, Carlsson P, Kentson M,. et al.Deep venous thrombosis: a new task for primary health care. A randomised economic study of outpatient and inpatient treatment. Scand J Prim Health Care 2004;22:44-9
  • Comp PC, Spiro TE, Friedman RJ, et al., and the Enoxaparin Clinical Trial Group. Prolonged enoxaparin therapy to prevent venous thromboembolism after primary hip or knee replacement. Enoxaparin Clinical Trial Group. J Bone Joint Surg Am 2001;83-A:336-45
  • Ingelgard A, Hedner E, Stigendal J, et al. Patient-reported outcomes in patients with deep vein thrombosis treated with warfarin. Poster presented at the 17th International Congress on Thrombosis; Bologna, Italy. Oct 26-30, 2002
  • Gage BF, Cardinalli AB, Owens DK. The effect of stroke and stroke prophylaxis with aspirin or warfarin on quality of life. Arch Intern Med 1996;156:1829-36
  • Lenert LA, Soetikno RM. Automated computer interviews to elicit utilities: potential applications in the treatment of deep venous thrombosis. J Am Med Inform Assoc 1997;4:49-56
  • O’Meara 3rd JJ, McNutt RA, Evans AT,. et al.A decision analysis of streptokinase plus heparin as compared with heparin alone for deep-vein thrombosis. N Engl J Med 1994; 330:1864-9
  • Robinson A, Thomson R, Parkin D,. et al.How patients with atrial fibrillation value different health outcomes: a standard gamble study. J Health Serv Res Policy 2001;6:92-8
  • Hansson PO, Sorbo J, Eriksson H. Recurrent venous thromboembolism after deep vein thrombosis: incidence and risk factors. Arch Intern Med 2000;160:769-74
  • Ziegler S, Schillinger M, Maca TH,. et al.Post-thrombotic syndrome after primary event of deep venous thrombosis 10 to 20 years ago. Thromb Res 2001;101:23-33
  • Prandoni P, Lensing AW, Piccioli A,. et al.Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis. Blood 2002;100:3484-8
  • Kyrle PA, Minar E, Bialonczyk C,. et al.The risk of recurrent venous thromboembolism in men and women. N Engl J Med 2004;350:2558-63
  • Prandoni P. Risk factors of recurrent venous thromboembolism: the role of residual vein thrombosis. Pathophysiol Haemost Thromb 2003 Sep-2004 Dec;33:351-3
  • Beyth RJ, Cohen AM, Landefeld CS. Long-term outcomes of deep-vein thrombosis. Arch Intern Med 1995;155:1031-7
  • Prandoni P, Lensing AW, Prins MH,. et al.Below-knee elastic compression stockings to prevent the post-thrombotic syndrome: a randomized, controlled trial. Ann Intern Med 2004; 141:249-56
  • Singh H, Masuda EM. Comparing short-term outcomes of femoral-popliteal and iliofemoral deep venous thrombosis: early lysis and development of reflux. Ann Vasc Surg 2005; 19:74-9
  • Ginsberg JS, Turkstra F, Buller HR,. et al.Postthrombotic syndrome after hip or knee arthroplasty: a cross-sectional study. Arch Intern Med 2000;160:669-72
  • Monreal M, Martorell A, Callejas JM,. et al.Venographic assessment of deep vein thrombosis and risk of developing post-thrombotic syndrome: a prospective study. J Intern Med 1993; 233:233-8
  • Kakkar VV, Lawrence D. Hemodynamic and clinical assessment after therapy for acute deep vein thrombosis. A prospective study. Am J Surg 1985;150(4A):54-63
  • Lindner DJ, Edwards JM, Phinney ES,. et al.Long-term hemodynamic and clinical sequelae of lower extremity deep vein thrombosis. J Vasc Surg 1986;4:436-42
  • Franzeck UK, Schalch I, Bollinger A. On the relationship between changes in the deep veins evaluated by duplex sonography and the post-thrombotic syndrome 12 years after deep vein thrombosis. Thromb Haemost 1997;77: 1109-12
  • Janssen MC, Haenen JH, van Asten AW,. et al.Clinical and haemodynamic sequelae of deep venous thrombosis: retrospective evaluation after 7–13 years. Clin Sci 1997;93:7-12
  • McNally MA, McAlinden MG, O’Connell BM,. et al.Postphlebitic syndrome after hip arthroplasty. 43 patients followed at least 5 years. Acta Orthop Scand 1994;65:595-8
  • Guide to the methods of technology appraisal. London: National Institute for Health and Clinical Excellence, 2004. Available at: http://www.nice.org.uk/page.aspx?o=201974 [Last accessed 31 March 2008]
  • Bucher HC, Guyatt GH, Griffith LE,. et al.The results of direct and indirect treatment comparisons in meta-analysis of randomized controlled trials. J Clin Epidemiol 1997; 50: 683-91

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