334
Views
18
CrossRef citations to date
0
Altmetric
Original Article

Comparison of efficacy and safety of ciprofloxacin otic solution 0.2% versus polymyxin B-neomycin-hydrocortisone in the treatment of acute diffuse otitis externa

, , , , &
Pages 3531-3542 | Accepted 28 Oct 2008, Published online: 18 Nov 2008

References

  • Roland PS, Stroman DW. Microbiology of acute otitis externa. Laryngoscope 2002;112:1166-77
  • Arshad M, Khan NU, Ali N, et al. Sensitivity and spectrum of bacterial isolates in infectious otitis externa. J Coll Physicians Surg Pak 2004;14:146-9
  • Dibb WL. Microbial aetiology of otitis externa. J Infect 1991;22:233-9
  • Battikhi MN, Ammar SI. Otitis externa infection in Jordan. Clinical and microbiologic features. Saudi Med J 2004;25:1199-203
  • Sander R. Otitis externa: a practical guide to treatment and prevention. Am Fam Physician 2001;63:927-36
  • Osguthorpe JD, Nielsen DR. Otitis externa: review and clinical update. Am Fam Physician 2006;74:1510-6
  • Rosenfeld RM, Brown L, Cannon CR, et al. Clinical practice guidelines: acute otitis externa. Otolaryngol Head Neck Surg 2006;134:S4-23
  • van Asperen IA, de Rover CM, Schijven JF, et al. Risk of otitis externa after swimming in recreational fresh water lakes containing Pseudomonas aeruginosa. BMJ 1995;311:1407-10
  • Hannley MT, Denneny JC III, Holzer SS. Use of ototopical antibiotics in treating 3 common ear diseases. Otolaryngol Head Neck Surg 2000;122:934-40
  • Dohar JE. Evolution of management approaches for otitis externa. Pediatr Infect Dis J 2003;22:229-308
  • Roland PS, Pien FD, Schultz CC, et al. Efficacy and safety of topical ciprofloxacin/dexamethasone versus neomycin/polymyxin B/hydrocortisone for otitis externa. Curr Med Res Opin 2004;20:1175-83
  • Torun B, Block SL, Avila H, et al. Efficacy of ofloxacin otic solution once daily for 7 days in the treatment of otitis externa: a multicenter, open-label, phase III trial. Clin Ther 2004;26:1046-54
  • Pistorius B, Westberry K, Drehobl M, et al. Prospective, randomized, comparative trial of ciprofloxacin otic drops, with or without hydrocortisone, vs. polymyxin B-neomycin-hydrocortisone otic suspension in the treatment of acute diffuse otitis externa. Infect Dis Clin Pract 1999;8:387-95
  • Block SL. Otitis externa: providing relief while avoiding complications. J Fam Pract 2005;54:669-76
  • Beers SL, Abramo TJ. Otitis externa review. Pediatr Emerg Care 2004;20:250-6
  • Cantrell HF, Lombardy EE, Duncanson FP, et al. Declining susceptibility to neomycin and polymyxin B of pathogens recovered in otitis externa clinical trials. South Med J 2004;97:465-71
  • Jones RN, Milazzo J, Seidlin M. Ofloxacin otic solution for treatment of otitis externa in children and adults. Arch Otolaryngol Head Neck Surg 1997;123:1193-200
  • Schwartz RH. Once-daily ofloxacin otic solution versus neomycin sulfate/polymyxin B sulfate/hydrocortisone otic suspension four times a day: a multicenter, randomized, evaluator-blinded trial to compare the efficacy, safety, and pain relief in pediatric patients with otitis externa. Curr Med Res Opin 2006;22:1725-33
  • Arnes E, Dibb WL. Otitis externa: clinical comparison of local ciprofloxacin versus local oxytetracycline, polymyxin B, hydrocortisone combination treatment. Curr Med Res Opin 1993;13:182-6
  • Goldenberg D, Golz A, Netzer A, et al. The use of otic powder in the treatment of acute external otitis. Am J Otolaryngol 2002;23:142-7
  • Vallés H. Evaluation of the efficacy and safety of topic otic ciprofloxacin (0.3%) in the treatment of diffuse external otitis and chronic middle otitis [in Spanish]. ORL-DIPS 2000;27:9-14
  • Quesada P, Lorente J, Arjona F, et al. Multicenter drug surveillance study on topic otic ciprofloxacin 0.3% in children affected with diffuse otitis externa [in Spanish]. Rev Esp Pediatr 1998;54:195-202
  • Quesada P, Lorente J, García M, et al. Multicenter drug surveillance study on topical ciprofloxacin in patients affected with diffuse otitis externa [in Spanish]. Salud Rural 1999;7:119-29
  • Clarós Blanch P, Sánchez García F, Rodríguez Leal A, et al. Clinical study to evaluate the effectiveness of 0.3% ciprofloxacin in children with diffuse external otitis [in Spanish]. Acta Pediatr Esp 2000;58:358-62
  • Ganz H. Local antibiotic therapy of bacterial ear infections [in German]. HNO 1989;37:386-8
  • Stange G. Local treatment of Pseudomonas infection of the ear [in German]. Laryngorhinootologie 1989;68:653-6
  • Miniti A, Ubirajara Sennes L, Bento RF. Topic treatment of acute external otitis and acute and chronic media otitis with ciprofloxacin 0.5% [in Portuguese]. Rev Bras Med 1993;50:675-6
  • Garcia Rodriguez JA, Garcia Sanchez JE, Garcia Garcia MI, et al. Efficacy of topical ciprofloxacin in the treatment of ear infections in adults. J Antimicrob Chemother 1993;31:452-3
  • De Schepper S, Schmelzer B. Local treatment of otitis media and otitis externa: the role of quinolones [in Dutch]. Acta Otorhinolaryngol Belg 1994;48:67-70
  • Conroy PJ. New quinolone/steroid combination for topical treatment of acute otitis: early- and late-phase study results. Ear Nose Throat J 2003;82 (Suppl.):1-4
  • Rosenfeld RM, Singer M, Wasserman JM, et al. Systematic review of topical antimicrobial therapy for acute otitis externa. Otolaryngol Head Neck Surg 2006;134 (4 Suppl.):S24-S48
  • Bojrab DI, Bruderly T, Abdulrazzak Y. Otitis externa. Otolaryngol Clin North Am 1996;29:761-82
  • Myer CM. The evolution of ototopical therapy: From cumin to quinolones. Ear Nose Throat J 2004;83 (Suppl.):9-11
  • Rutka J. Acute otitis externa: treatment perspectives. Ear Nose Throat J 2004;83 (9 Suppl. 4):20-2
  • Simpson KL, Markham A. Ofloxacin otic solution: a review of its use in the management of ear infections. Drugs 1999;58:509-31
  • McCoy SI, Zell ER, Besser RE. Antimicrobial prescribing for otitis externa in children. Pediatr Infect Dis J 2004;23:181-3
  • Blackwelder WC. “Proving the null hypothesis” in clinical trials. Control Clin Trials 1982;3:345-53
  • Clark WB, Brook I, Bianki D, et al. Microbiology of otitis externa. Otolaryngol Head Neck Surg 1997;116:23-5
  • Wilkinson SM, Beck MH. Hypersensitivity to topical corticosteroids in otitis externa. J Laryngol Otol 1993;107:597-9
  • Wright CG, Roland PS. Middle ear effects of ototopical agents. In: Roland P, Rutka J., eds. Ototoxicity. Hamilton, ON: BC Decker Inc., 2004
  • Spandow O, Anniko M, Hellstrom S. Hydrocortisone applied into the round window niche causes electrophysiological dysfunction of the inner ear. ORL J Otorhinolaryngol Relat Spec 1989;51:94-102
  • Perrenoud D, Bircher A, Hunziker T, et al. Frequency of sensitization to 13 common preservatives in Switzerland. Contact Dermatitis 1994;30:276-9

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.