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Brief Report

Effect of propionyl-l-carnitine, l-arginine and nicotinic acid on the efficacy of vardenafil in the treatment of erectile dysfunction in diabetes

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Pages 2223-2228 | Accepted 24 Jun 2009, Published online: 23 Jul 2009

References

  • Bivalacqua TJ, Usta MF,Champion HC, et al. Endothelial dysfunction in erectile dysfunction: role of the endothelium in erectile physiology and disease. J Androl 2003;24:17-37
  • Bivalacqua TJ, Champion HC, Usta MF, et al. Rho A/Rho-Kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction. Proc Natl Acad Sci 2004;10:9121
  • Musicki B, Burnett AL. ENOS function and dysfunction in the penis. Exp Biol Med 2006; 231:154-165
  • Pacher P, Beckman JS, Liaudet L. Nitric oxide and peroxynitrite in heath and disease. Physiol Rev 2007;87:315-424
  • Ceriello A. New insights on oxidative stress and diabetic complications may lead to a “causal” antioxidant therapy. Diabetes Care 2003;26:1589-96
  • Bohlen HG, Hash JM. Topical hyperglycemia rapidly suppresses EDRF-mediated vasodilation of normal rat arterioles. Am J Physiol 1993;265:219-25
  • Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001;414:813-20
  • Riccioni C, Sarcinella R, Palermo G, et al. Evaluation of the efficacy of propionyl-L-carnitine versus pulsed muscular compressions in diabetic and non-diabetic patients affected by obliterating arteriopathy Leriche stage II. Int Angiol 2008;27:253-9
  • Virmani A, Ali SF, Binienda ZK. Neuroprotective strategies in drug abuse-evoked encephalopathy. Ann N Y Acad Sci 2009. In press
  • Gur S, Kadowitz PJ, Trost L, et al. Optimizing nitric oxide production by time dependent L-arginine administration in isolated human corpus cavernosum. J Urol 2007;178(4 Pt 1):1543-8
  • Klinge E, Alaranta S, Sjöstrand NO. Pharmacological analysis of nicotinic relaxation of bovine retractor penis muscle. J Pharmacol Exp Ther 1988;245:280-6
  • Lau DH, Mumtaz FH, Mikhailidis DP, et al. In vitro and in vivo effects of vardenafil (a PDE-5 inhibitor) on corpus cavernosal smooth muscle relaxation in diabetic rabbits. Urol Int 2009;82:101-7
  • Corretti MC, Anderson TJ, Benijamin EJ, et al. Guidelines for the ultrasound-assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery. J Am Coll Cardiol 2002;39:257-65
  • Glantz SA. Primer of Biostatistics. New York: McGraw Hill
  • Kannel WB, McGee DL. Diabetes and cardiovascular diseases: the Framingham Study. JAMA 1979;241:2035-8
  • Laakso M. Hyperglycemia and cardiovascular disease in type 2 diabetes. Diabetes 1998;48:937-42
  • Kawano H, Motoyama T, Hirashimi O, et al. Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilation of brachial artery. J Am Coll Cardiol 1999;34:146-54
  • Brodsky SV, Gao S, Li H, Goligorsky MS: hyperglycemic switch from mitochondrial nitric oxide to superoxide production in endothelial cells. Am J Physiol 2002;283:2130-9
  • Cerriello A, Mercuri F, Quagliaro L, et al. Detection of nitrotyrosine in the diabetic plasma: evidence of oxidative stress. Diabetologia 2001;44:834-8
  • Ceriello A, Quagliaro L, Catone B, et al. The role of hyperglycemia in nitrotyrosine postprandial generation. Diabetes Care 2002;25:1439-43
  • Cotter MA, Cameron NE, Keegan A, et al. Effect of acetyl and propionyl-L-carnitine on isolated mitochondrial function in the reperfused diabetic heart. Diabetes Res Clin Pract 2001;53:17-24
  • Rani PJ, Panneerselvam C. Effect of L-carnitine on brain lipid peroxidation and antioxidant enzymes in old rats. J Gerontol A Biol Sci Med Sci 2002;57:B134-7
  • Savitha S, Tamilselvan J, Anusuyadevi M, et al. Oxidative stress on mitochondrial antioxidant defense system in the aging process: role of DL-α-lipoic acid and L-carnitine. Clin Chim Acta 2005;35:173-80
  • Gigliano D, Martella R, Coppola L, et al. Vascular affects of acute hyperglycemia in humans are reversed by L-arginine evidence for reduced availability of nitric oxide during hyperglycemia. Circulation 1997;95:1783-90
  • Offermanns S. The nicotinic acid receptor GPR109A (HM74A or PUMAG) as a new therapeutic target. Trends Pharmacol Sci 2007;27:384-90
  • Kondoh N, Higuchi Y, Maruyama T, et al. Salvage therapy trial for erectile dysfunction using phosphodiesterase type 5 inhibitors and vitamin E: preliminary report. Aging Male 2008;11:167-70

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