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Original Article

Efficacy of vitamin D3 supplementation in preventing fractures in elderly women: A meta-analysis

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Pages 1193-1201 | Accepted 28 Jan 2010, Published online: 22 Mar 2010

References

  • Hodgson SF, Watts NB, Bilezikian JP, et al. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the prevention and treatment of postmenopausal osteoporosis: 2001 edition, with selected updates for 2003. Endocr Pract 2003;9:544-64
  • Epstein S. Postmenopausal osteoporosis: fracture consequences and treatment efficacy vary by skeletal site. Aging (Milano) 2000;12:330-41
  • National Osteoporosis Foundation. Fast Facts on Osteoporosis. 2007 [cited 2010; Available from: http://www.nof.org/osteoporosis/diseasefacts.htm
  • US Department of Health and Human Services. Bone Health and Osteoporosis: A Report of the Surgeon General. 2004 [cited 2010; Available from: http://www.surgeongeneral.gov/library/bonehealth/content.html
  • Melton LJ 3rd. Adverse outcomes of osteoporotic fractures in the general population. J Bone Miner Res 2003;18:1139-41
  • Olsson C, Petersson C, Nordquist A. Increased mortality after fracture of the surgical neck of the humerus: a case-control study of 253 patients with a 12-year follow-up. Acta Orthop Scand 2003;74:714-17
  • Cummings SR, Melton LJ. Epidemiology and outcomes of osteoporotic fractures. Lancet 2002;359:1761-7
  • Orsini LS, Rousculp MD, Long SR, et al. Health care utilization and expenditures in the United States: a study of osteoporosis-related fractures. Osteoporos Int 2005;16:359-71
  • Schneider EL, Guralnik JM. The aging of America. Impact on health care costs. JAMA 1990;263:2335-40
  • Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc 2006;81:353-73
  • Malavolta N, Pratelli L, Frigato M, et al. The relationship of vitamin D status to bone mineral density in an Italian population of postmenopausal women. Osteoporos Int 2005;16:1691-7
  • Beringer T, Heyburn G, Finch M, et al. Prevalence of vitamin D inadequacy in Belfast following fragility fracture. Curr Med Res Opin 2006;22:101-5
  • Dixon T, Mitchell P, Beringer T, et al. An overview of the prevalence of 25-hydroxy-vitamin D inadequacy amongst elderly patients with or without fragility fracture in the United Kingdom. Curr Med Res Opin 2006;22:405-15
  • Gallacher SJ, McQuillian C, Harkness M, et al. Prevalence of vitamin D inadequacy in Scottish adults with non-vertebral fragility fractures. Curr Med Res Opin 2005;21:1355-61
  • Moniz C, Dew T, Dixon T. Prevalence of vitamin D inadequacy in osteoporotic hip fracture patients in London. Curr Med Res Opin 2005;21:1891-4
  • Ryan P, Dixon T. Prevalence of vitamin D inadequacy in patients attending a metabolic bone clinic in Medway. Curr Med Res Opin 2006;22:211-16
  • Simonelli C, Weiss TW, Morancey J, et al. Prevalence of vitamin D inadequacy in a minimal trauma fracture population. Curr Med Res Opin 2005;21:1069-74
  • Gaugris S, Heaney RP, Boonen S, et al. Vitamin D inadequacy among post-menopausal women: a systematic review. QJM 2005;98:667-76
  • Holick MF, Siris ES, Binkley N, et al. Prevalence of vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy. J Clin Endocrinol Metab 2005;90:3215-24
  • Bruyere O, Malaise O, Neuprez A, et al. Prevalence of vitamin D inadequacy in European postmenopausal women. Curr Med Res Opin 2007;23:1939-44
  • Moniz C, Dew T, Dixon T. Prevalence of vitamin D inadequacy in osteoporotic hip fracture patients in London. Curr Med Res Opin 2005;21:1891-4
  • Ness J, Aronow WS, Newkirk E, et al. Underutilization of calcium and vitamin D by older adults in a large general internal medicine practice. Am J Ther 2005;12:113-16
  • Hanley DA, Zhang Q, Meilleur MC, et al. Prescriptions for vitamin D among patients taking antiresorptive agents in Canada. Curr Med Res Opin 2007;23:1473-80
  • Bayly JR, Hollands RD, Riordan-Jones SE, et al. Prescribed vitamin D and calcium preparations in patients treated with bone remodelling agents in primary care: a report of a pilot study. Curr Med Res Opin 2006;22:131-7
  • Solomon DH, Morris C, Cheng H, et al. Medication use patterns for osteoporosis: an assessment of guidelines, treatment rates, and quality improvement interventions. Mayo Clin Proc 2005;80:194-202
  • Tang BM, Eslick GD, Nowson C, et al. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet 2007;370:657-66
  • Bischoff-Ferrari HA, Willett WC, Wong JB, et al. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 2005;293:2257-64
  • Jackson C, Gaugris S, Sen SS, et al. The effect of cholecalciferol (vitamin D3) on the risk of fall and fracture: a meta-analysis. QJM 2007;100:185-92
  • Boonen S, Lips P, Bouillon R, et al. Need for additional calcium to reduce the risk of hip fracture with vitamin d supplementation: evidence from a comparative metaanalysis of randomized controlled trials. J Clin Endocrinol Metab 2007;92:1415-23
  • Leonard T, Duffy JC. A Bayesian fixed effects analysis of the Mantel-Haenszel model applied to meta-analysis. Stat Med 2002;21:2295-312
  • Goodman SN. Toward evidence-based medical statistics. 2: The Bayes factor. Ann Intern Med 1999;130:1005-13
  • Trivedi DP, Doll R, Khaw KT. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ 2003;326:469
  • Grant AM, Avenell A, Campbell MK, et al. Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet 2005;365:1621-8
  • Pfeifer M, Begerow B, Minne HW, et al. Effects of a short-term vitamin D and calcium supplementation on body sway and secondary hyperparathyroidism in elderly women. J Bone Miner Res 2000;15:1113-18
  • Chapuy MC, Arlot ME, Duboeuf F, et al. Vitamin D3 and calcium to prevent hip fractures in the elderly women. N Engl J Med 1992;327:1637-42
  • Chapuy MC, Arlot ME, Delmas PD, et al. Effect of calcium and cholecalciferol treatment for three years on hip fractures in elderly women. BMJ 1994;308:1081-2
  • Chapuy MC, Pamphile R, Paris E, et al. Combined calcium and vitamin D3 supplementation in elderly women: confirmation of reversal of secondary hyperparathyroidism and hip fracture risk: the Decalyos II study. Osteoporos Int 2002;13:257-64
  • Porthouse J, Cockayne S, King C, et al. Randomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care. BMJ 2005;330:1003
  • Dawson-Hughes B, Harris SS, et al. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 1997;337:670-6
  • Bischoff-Ferrari HA, Willett WC, Wong JB, et al. Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med 2009;169:551-61
  • Bischoff-Ferrari H, Shao A, Dawson-Hughes B, et al. Benefit–risk assessment of vitamin D supplementation. Osteoporos Int 2009 Dec 3. [Epub ahead of print]
  • Jackson RD, LaCroix AZ, Gass M, et al. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 2006;354:669-83
  • University of Wisconsin. Does treatment of hypovitaminosis D increase calcium absorption? In: ClinicalTrialsgov [Internet] Bethesda (MD): National Library of Medicine (US) 2000-[cited 2010 Jan 6] [cited NLM Identifier: NCT00581828; Available from: http://clinicaltrials.gov/ct2/show/NCT00581828
  • University of Wisconsin. Vitamin D Administration in the nursing home. In: ClinicalTrialsgov [Internet] Bethesda (MD): National Library of Medicine (US) 2000- [cited 2010 Jan 5] [cited; Available from: http://clinicaltrials.gov/ct2/show/NCT00204919
  • Bischoff-Ferrari HA, Dawson-Hughes B. Where do we stand on vitamin D?. Bone 2007;41:S13-19
  • Agency for Healthcare and Research Quality. Effectiveness and safety of vitamin D in relation to bone health: US Department of Health and Human Services, 2007
  • Brown SE. Vitamin D and fracture reduction: an evaluation of the existing research. Altern Med Rev 2008;13:21-33
  • Mittlbock M, Heinzl H. A simulation study comparing properties of heterogeneity measures in meta-analyses. Stat Med 2006;25:4321-33
  • Sterne JA, Gavaghan D, Egger M. Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature. J Clin Epidemiol 2000;53:1119-29
  • Thompson SG, Sharp SJ. Explaining heterogeneity in meta-analysis: a comparison of methods. Stat Med 1999;18:2693-708
  • Resch H, Walliser J, Phillips S, et al. Physician and patient perceptions on the use of vitamin D and calcium in osteoporosis treatment: a European and Latin American perspective. Curr Med Res Opin 2007;23:1227-37
  • Avenell A, Gillespie WJ, Gillespie LD, O’Connell D. Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis. Cochrane Database Syst Rev 2009:CD000227

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