Proof of concept study: does fenofibrate have a role in sleep apnoea syndrome?

References

• Young T, Peppard PE, Gottlieb DJ. Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med 2002;165:1217-39
   PubMed Web of Science ®Google Scholar
• Shamsuzzaman AS, Gersh BJ, Somers VK. Obstructive sleep apnea: implications for cardiac and vascular disease. JAMA 2003;290:1906-14
   PubMed Web of Science ®Google Scholar
• Coughlin SR, Mawdsley L, Mugarza JA, et al. Obstructive sleep apnoea is independently associated with an increased prevalence of metabolic syndrome. Eur Heart J 2004;25:735-41
   PubMed Web of Science ®Google Scholar
• Kono M, Tatsumi K, Saibara T, et al. Obstructive sleep apnea syndrome is associated with some components of metabolic syndrome. Chest 2007;131:1387-92
   PubMed Web of Science ®Google Scholar
• Nock NL, Li L, Larkin EK, et al. Empirical evidence for ‘Syndrome z’: a hierarchial 5-factor model of the metabolic syndrome incorporating sleep disturbance measures. Sleep 2009;32:615-22
   PubMed Web of Science ®Google Scholar
• Yamauchi M, Nakano H, Maekawa J, et al. Oxidative stress in obstructive sleep apnea. Chest 2005;127:1674-9
   PubMed Web of Science ®Google Scholar
• Lavie L. Obstructive sleep apnoea syndrome – an oxidative stress disorder. Sleep Med Rev 2003;7:35-51
   PubMed Web of Science ®Google Scholar
• Narkiewicz K, Somers VK. Sympathetic nerve activity in obstructive sleep apnea. Acta Physiol Scand 2003;177:385-90
   PubMedGoogle Scholar
• Lam JCM, Xu A, Tam S, et al. Hypoadipnectinemia is related to sympathetic activation and severity of obstructive sleep apnea. Sleep 2008;31:1721-7
   PubMed Web of Science ®Google Scholar
• Ryan S, Taylor CT, McNicholas WT. Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome. Circulation 2005;112:2660-7
   PubMed Web of Science ®Google Scholar
• Hatipoğlu U, Rubinstein I. Inflammation and obstructive sleep apnea syndrome pathogenesis: a working hypothesis. Respiration 2003;70:665-71
   PubMed Web of Science ®Google Scholar
• Htoo AK, Greenberg H, Tongia S, et al. Activation of nuclear factor kappaB in obstructive sleep apnea: a pathway leading to systemic inflammation. Sleep Breath 2006;10:43-50
   PubMed Web of Science ®Google Scholar
• Irwin MR, Wang M, Campomayor CO, et al. Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation. Arch Intern Med 2006;166:1756-62
   PubMed Web of Science ®Google Scholar
• Johnson JD, Campisi J, Sharkey CM, et al. Catecholamines mediate stress-induced increases in peripheral and central inflammatory cytokines. Neuroscience 2005;135:1295-307
   PubMed Web of Science ®Google Scholar
• Tsimihodimos V, Liberopoulos E, Elisaf M. Pleiotropic effects of fenofibrate. Curr Pharm Des 2009;15:517-28
   PubMed Web of Science ®Google Scholar
• Rosenson RS, Huskin AL, Wolff DA, et al. Fenofibrate reduces fasting and postprandial inflammatory responses among hypertriglyceridaemia patients with the metabolic syndrome. Atherosclerosis 2008;198:381-8
   PubMed Web of Science ®Google Scholar
• Rosenson RS, Wolff DA, Huskin AL, et al. Fenofibrate therapy ameliorates fasting and postprandial lipoproteinaemia, oxidative stress, and the inflammatory response in subjects with hypertriglyceridemia and the metabolic syndrome. Diabetes Care 2007;30:1945-51
   PubMed Web of Science ®Google Scholar
• Okopien B, Krysiak R, Kowalski J, et al. Monocyte release of tumor necrosis factor-alpha and interleukin-1beta in primary type IIa and IIb dyslipidemic patients treated with statins or fibrates. J Cardiovasc Pharmacol 2005;45:160-4
   PubMed Web of Science ®Google Scholar
• Delerive P, Fruchart JC, Staels B. Peroxisome proliferator-activated receptors in inflammation control. J Endocrinol 2001;169:453-9
   PubMed Web of Science ®Google Scholar
• Scottish Intercollegiate Gudelines Network. Guideline 73. Management of obstructive sleep apnoea/hypopnoea syndrome in adults. 2003. Available at: www.sign.ac.uk [Last accessed 13 January 2010]
   Google Scholar
• Johns MW. Daytime sleepiness, snoring, and obstructive sleep apnea. The Epworth Sleepiness Scale. Chest 1993;103:30-6
   PubMed Web of Science ®Google Scholar
• Van Surell C, Lemaigre D, Leroy M, et al. Evaluation of an ambulatory device, CID 102, in the diagnosis of obstructive sleep apnoea syndrome. Eur Respir J 1995;8:795-800
   PubMed Web of Science ®Google Scholar
• Condy C, Rivaud-Pechoux S, Ostendorf F, et al. Neural substrate of antisaccades: role of subcortical structures. Neurology 2004;63:1571-8
   PubMed Web of Science ®Google Scholar
• Rivaud-Pechoux S, Vermersch AI, Gaymard B, et al. Improvement of memory guided saccades in parkinsonian patients by high frequency subthalamic nucleus stimulation. J Neurol Neurosurg Psychiatry 2000;68:381-4
   PubMed Web of Science ®Google Scholar
• Ploner CJ, Tschirch A, Ostendorf F, et al. Oculomotor effects of delta-9-tetrahydrocannabinol in humans: implications for the functional neuroanatomy of the brain cannabinoid system. Cereb Cortex 2002;12:1016-23
   PubMed Web of Science ®Google Scholar
• Johansson K, Neovius M, Lagerros YT, et al. Effect of a very low energy diet on moderate and severe obstructive sleep apnoea in obese men: a randomised controlled trial. BMJ 2009;339:B4609. DOI: 10.1136/bmj.b4609
   PubMed Web of Science ®Google Scholar
• Roizenblatt S, Guilleminault C, Poyares D, et al. A double-blind, placebo-controlled, cross-over study of sildenafil in obstructive sleep apnea. Arch Intern Med 2008;166:1763-7
   Web of Science ®Google Scholar
• Thickett EM, Hirani S, Williams A, et al. A prospective evaluation assessing the effectiveness o the ‘Dynamax’ mandibular appliance in the management of obstructive sleep apnoea. Surgeon 2009;7:4-7
   PubMed Web of Science ®Google Scholar
• Smith I, Lasserson TJ, Wright J. Drug therapy for obstructive sleep apnoea in adults. Cochrane Database Syst Rev 2006;Apr 19(2):CD003002
   Google Scholar
• Horner RL. The neuropharmacology of upper airway motor control in the awake and asleep states: implications for obstructive sleep apnoea. Respir Res 2001;2:286-94
   PubMed Web of Science ®Google Scholar
• Hanzel DA, Proia NG, Hudgel DW. Response of obstructive sleep apnea to fluoxetine and protriptyline. Chest 1991;100:416-21
   PubMed Web of Science ®Google Scholar
• Melien O, Skaali T, Myhr K, et al. Venlafaxine and asthma. Nordic J Psychiatr 2005;59:538-50
   PubMed Web of Science ®Google Scholar