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Current Medical Research and Opinion Volume 26, 2010 - Issue 9
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Original Article

Evaluation of compliance and health care utilization in patients treated with single pill vs. free combination antihypertensives

Weiyi Yang Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA
,
Joanne Chang Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA
,
Kristijan H. Kahler Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA
,
Thomas Fellers Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA
,
John Orloff Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA
,
Eric Q. Wu Analysis Group, Inc., Boston, MA, USACorrespondence[email protected]
&
Arielle G. Bensimon Analysis Group, Inc., Boston, MA, USA
 show all
Pages 2065-2076 | Accepted 17 May 2010, Published online: 15 Jul 2010

References

  • Cutler JA, Sorlie PD, Wolz M, et al. Trends in hypertension prevalence, awareness, treatment, and control rates in United States adults between 1988–1994 and 1999–2004. Hypertension 2008;52:818-27
  • Ong KL, Cheung BM, Man YB, et al. Prevalence, awareness, treatment, and control of hypertension among United States adults, 1999–2004. Hypertension 2007;49:69-75
  • Chobanian AV, Bakris GL, Black HR, et al.; The National High Blood Pressure Education Program Coordinating Committee. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. U.S. Department of Health and Human Services, National Institute of Health. Available at: http://www.nhlbi.nih.gov/guidelines/hypertension/jnc7full.pdf [Last accessed 3 March 2009]
  • Hajjar I, Kotchen TA. Trends in the prevalence, awareness, treatment, and control of hypertension in the United States, 1988–2000. JAMA 2003;290:199-206
  • Law MR, Wald NJ, Morris JK, et al. Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials. BMJ 2003;326:1427-31
  • Neutel JM. Prescribing patterns in hypertension: the emerging role of fixed-dose combinations for attaining BP goals in hypertensive patients. Curr Med Res Opin 2008;24:2389-401
  • Gu Q, Paulose-Ram R, Dillon C, et al. Antihypertensive medication use among US adults with hypertension. Circulation 2006;113:213-21
  • Bramley TJ, Gerbino PP, Nightengale BS, et al. Relationship of blood pressure control to adherence with antihypertensive monotherapy in 13 managed care organizations. J Manag Care Pharm 2006;12:239-245
  • Bangalore S, Kamalakkannan G, Parkar S, et al. Fixed-dose combinations improve medication compliance: a meta-analysis. Am J Med 2007;120:713-19
  • Rizzo JA, Simons WR. Variations in compliance among hypertensive patients by drug class: implications for health care costs. Clin Ther 1997;19:1446-57
  • DiMatteo MR, Giordani PJ, Lepper HS, et al. Patient adherence and medical treatment outcomes: a meta-analysis. Med Care 2002;40:794-811
  • Gupta AK, Arshad S, Poulter NR. Compliance, safety, and effectiveness of fixed-dose combinations of antihypertensive agents. A meta-analysis. Hypertension 2010;55:399-407
  • Chrysant SG. Using fixed-dose combination therapies to achieve blood pressure goals. Clin Drug Investig 2008;28:713-34
  • Dezii CM. A retrospective study of persistence with single-pill combination therapy vs. concurrent two-pill therapy in patients with hypertension. Manag Care 2000;9(9 Suppl.):2-6
  • Nissinen A, Tuomilehto J. Evaluation of the antihypertensive effect of atenolol in fixed or free combination with chlorthalidone. Pharmatherapeutica 1980;2:462-8
  • Asplund J, Danielson M, Ohman P. Patients compliance in hypertension – the importance of number of tablets. Br J Clin Pharmacol 1984;17:547-52
  • Jackson KC 2nd, Sheng X, Nelson RE, et al. Adherence with multiple-combination antihypertensive pharmacotherapies in a US managed care database. Clin Ther 2008;30:1558-63
  • Brixner DI, Jackson KC 2nd, Sheng X, et al. Assessment of adherence, persistence, and costs among valsartan and hydrochlorothiazide retrospective cohorts in free- and fixed-dose combinations. Curr Med Res Opin 2008;24:2597-607
  • Hess G, Hill J, Lau H, et al. Medication utilization patterns and hypertension-related expenditures among patients who were switched from fixed-dose to free-combination antihypertensive therapy. P&T 2008;33:652-66
  • Deyo RA, Cherkin DC, Ciol MA. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol 1992;45:613-19
  • Green PJ. Penalized likelihood for general semi-parametric regression models. Int Stat Rev 1987;55:245-59
  • Ruppert D, Wand MP, Carroll RJ. Semiparametric regression. New York: CUP, 2003
  • Jamerson K, Weber MA, Bakris GL, et al. The ACCOMPLISH Trial Investigators. Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients. N Engl J Med 2008;359:2417-28
  • Taylor AA, Shoheiber O. Adherence to antihypertensive therapy with fixed-dose amlodipine besylate/benazepril HCl versus comparable component-based therapy. Congest Heart Fail 2003;9:324-32
  • Burnier M. Medication adherence and persistence as the cornerstone of effective antihypertensive therapy. Am J Hypertens 2006;19:1190-6

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