543
Views
23
CrossRef citations to date
0
Altmetric
Allergy: Review

Efficacy and safety of rupatadine for allergic rhino-conjunctivitis: a systematic review of randomized, double-blind, placebo-controlled studies with meta-analysis

&
Pages 1539-1551 | Accepted 28 Jun 2013, Published online: 06 Aug 2013

References

  • Skoner DP. Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis. J Allergy Clin Immunol 2001;108:S2-8
  • Katelaris CH, Lee BW, Potter PC, et al. Prevalence and diversity of allergic rhinitis in regions of the world beyond Europe and North America. Clin Exp Allergy 2012;42:186-207
  • Bousquet J, Schünemann HJ, Samolinski B, et al; World Health Organization Collaborating Center for Asthma and Rhinitis. Allergic Rhinitis and its Impact on Asthma (ARIA): Achievements in 10 years and future needs. J Allergy Clin Immunol 2012;130:1049-62
  • Rosenwasser LJ. Current understanding of the pathophysiology of allergic rhinitis. Immunol Allergy Clin North Am 2011;31:433-9
  • Feng CH, Miller MD, Simon RA. The united allergic airway: connections between allergic rhinitis, asthma, and chronic sinusitis. Am J Rhinol Allergy 2012;26:187-90
  • Simons FE, Simons KJ. Histamine and H1-antihistamines: celebrating a century of progress. J Allergy Clin Immunol 2011;128:1139-50
  • Baroody FM, Naclerio RM. Antiallergic effects of H1-receptor antagonists. Allergy 2000;55:17-27
  • Izquierdo I, Merlos M, García-Rafanell J. Rupatadine: a new selective histamine H1 receptor and platelet-activating factor (PAF) antagonist. A review of pharmacological profile and clinical management of allergic rhinitis. Drugs Today (Barc) 2003;39:451-68
  • Merlos M, Giral M, Balsa D, et al. Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF). J Pharmacol Exp Ther 1997;280:114-21
  • Akagi M, Kanoh R, Fukuishi N, et al. Contribution of platelet activating factor (PAF) in histamine-induced model of nasal allergy in rats. Arerugi 1995;44:182-8
  • Tedeschi A, Milazzo N, Miadonna A. Nasal eosinophilia induced by PAF-acether is accompanied by the release of eosinophil cationic protein. Eur Respir J 1994;7:1445-51
  • Klementsson H, Andersson M. Eosinophil chemotactic activity of topical PAF on the human nasal mucosa. Eur J Clin Pharmacol 1992;42:295-9
  • Mullol J, Bousquet J, Bachert C, et al. Rupatadine in allergic rhinitis and chronic urticaria. Allergy 2008;63:5-28
  • Metz M, Maurer M. Rupatadine for the treatment of allergic rhinitis and urticaria. Expert Rev Clin Immunol 2011;7:15-20
  • Shekelle PG, Woolf SH, Eccles M, et al. Clinical guidelines: developing guidelines. BMJ 1999;318:593-6
  • Robinson KA, Dickersin K. Development of a highly sensitive search strategy for the retrieval of reports of controlled trials using PubMed. Int J Epidemiol 2002;31:150-3
  • The Cochrane Collaboration. Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.0. 2008. Available at: http://www.cochrane.org/training/cochrane-handbook [last acessed 25 Jul 2013]
  • DigitizeIt 1.5.7 program. Braunschweig: Bormann, 2003
  • Egger M, Smith GD, Phillips AN. Meta-analysis: principles and procedures. BMJ 1997;315:1533-7
  • Deeks JJ, Altman D, Bradburn MJ. Statistical methods for examining heterogeneity and combining results from several studies in meta-analysis. In Egger M, Davey Smith G, Altman DG (eds). Systematic Reviews in Health Care. London: BMJ, 2001:285-312
  • Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ 2003;327:557-60
  • Analyses Version 5.0 for Windows. Oxford: The Cochrane Collaboration, 2008
  • Marmouz F, Giralt J, Izquierdo I. Morning and evening efficacy evaluation of rupatadine (10 and 20 mg), compared with cetirizine 10 mg in perennial allergic rhinitis: a randomized, double-blind, placebo-controlled trial. J Asthma Allergy 2011;4:27-35
  • Valero A, Serrano C, Bartrá J, et al. Reduction of nasal volume after allergen-induced rhinitis in patients treated with rupatadine: a randomized, cross-over, double-blind, placebo-controlled study. J Investig Allergol Clin Immunol 2009;19:488-93
  • Fantin S, Maspero J, Bisbal C, et al; international rupatadine study group. A 12-week placebo-controlled study of rupatadine 10 mg once daily compared with cetirizine 10 mg once daily, in the treatment of persistent allergic rhinitis. Allergy 2008;63:924-31
  • Stuebner P, Horak F, Zieglmayer R, et al. Effects of rupatadine vs placebo on allergen-induced symptoms in patients exposed to aeroallergens in the Vienna Challenge Chamber. Ann Allergy Asthma Immunol 2006;96:37-44
  • Guadaño EM, Serra-Batlles J, Meseguer J, et al; Rupatadine Study Group. Rupatadine 10 mg and ebastine 10 mg in seasonal allergic rhinitis: a comparison study. Allergy 2004;59:766-71
  • Molina M, Pinto E, Cisteró A, et al. Rupatadine 10 mg in adolescent and adult symptom relief of perennial allergic rhinitis. Therapy 2010;7:429-36
  • Kowalski M, Jurkiewicz D, Kruszewski J, et al. Rupatadine 10 and 20 mg are effective and safe in the treatment of perennial allergic rhinitis after 4 weeks of treatment: a randomized, double-blind, controlled trial with loratadine and placebo. Therapy 2009;6:417-25
  • Izquierdo I, Pareds I, Lurigados C, et al. A dose ranging study of rupatadine fumarate in patients with seasonal allergic rhinitis. Allergy 2000;55:275
  • Potter P, Maspero J, Vermeulen J, et al. Allergy 2011;66:23
  • Lukat KF, Rivas P, Roger A, et al.; investigators working group clinical trial. A direct comparison of efficacy between desloratadine and rupatadine in seasonal allergic rhino-conjunctivitis: a randomised, double-blind, placebo-controlled study. J Asthma Allergy 2013;6:31-9
  • Martínez-Cócera C, De Molina M, Martí-Guadaño E, et al; Spanish Rupatadine Rhinitis Study Group. Rupatadine 10 mg and cetirizine 10 mg in seasonal allergic rhinitis: a randomised, double-blind parallel study. J Investig Allergol Clin Immunol 2005;15:22-9
  • Saint-Martin F, Dumur JP, Pérez I, et al; French Rupatadine-Rhinitis Study Group. A randomized, double-blind, parallel-group study, comparing the efficacy and safety of rupatadine (20 and 10 mg), a new PAF and H1 receptor-specific histamine antagonist, to loratadine 10 mg in the treatment of seasonal allergic rhinitis. J Investig Allergol Clin Immunol 2004;14:34-40
  • Mion O, Mello J, Castro F, et al. Rupatadine fumarate is effective in the treatment of persistent allergic rhinitis: a multicentre study. Allergy 2007;62:137, meeting abstract 361
  • Canonica GW, Fumagalli F. Rupatadine 10mg versus placebo on inflammatory parameters after allergen challenge in patients with persistent allergic rhinitis (PER). Allergy 2008;63:204, meeting abstract 522
  • Valero A, Bartra J, Serrano C, et al. Rupatadine reduces nasal obstruction in allergen-induced rhinitis. Allergy 2007;62:137, meeting abstract 362
  • Rivas P, Mesa M, Valero A, et al. Moderate–severe persistent allergic rhinitis: long-term safety treatment with rupatadine. XVIII IFOS World Congress. Rome, Italy: 25–30 June 2005. Abstract G58
  • Arnaiz E, Izquiierdo I, Leuratti C, et al. Rupatadine reduces nasal and non-nasal symptoms in patients with seasonal allergic rhinitis exposed to allergen in the Vienna Challenge Chamber. XXIII Congress of the European Academy of Allergology and Clinical Immunology (EAACI). Amsterdam, The Netherlands: 12–16 June, 2004. Abstract 272
  • Rothstein, H. R., Sutton, A. J. and Borenstein, M. Publication Bias in Meta-Analysis, in Publication Bias in Meta-Analysis: Prevention, Assessment and Adjustments (eds H. R. Rothstein, A. J. Sutton and M. Borenstein), John Wiley & Sons, Ltd, Chichester, UK. 2006. doi: 10.1002/0470870168.ch1
  • Duval S, Tweedie R. Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 2000;56:455-63
  • Egger M, Smith GD, O’rourke K. Systematic Reviews in Healthcare. Meta-analysis in Context. London: BMJ Publishing Group, 1995
  • Moher D, Liberati A, Tetzlaff J, et al. The PRISMA statement Group. Preferred Reporting Items for Systematic Reviews and Meta-analyses: The PRISMA Statement. PLoS Med 2009;6:e1000097 . doi:10.1371/journal.pmed.1000097
  • Sackett DL, Rosenberg WMC, Gray JAM. Evidence-Based Medicine: What it is and what it isn’t. BMJ 1996;312:71-2
  • Walsh GM. The clinical relevance of the anti-inflammatory properties of antihistamines. Allergy 2000;55:53-61
  • Church MK. Efficacy and tolerability of rupatadine at four times the recommended dose against histamine- and platelet-activating factor-induced flare responses and ex vivo platelet aggregation in healthy males. Br J Dermatol 2010;163:1330-2
  • Cohen J. Statistical Power Analysis for the Behavioral Sciences, 2nd edn. New Jersey: Lawrence Erlbaum, 1988
  • Schulz KF, Altman DG, Moher D; CONSORT Group. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMJ 2010;23;340:c332
  • Consolidated standards of reporting trials (CONSORT) and the completeness of reporting of randomised controlled trials (RCTs) published in medical journals. Cochrane Database Syst Rev 2012;11:MR000030
  • Guyatt GH, Oxman AD, Vist GE, et al; GRADE Working Group. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008; 336:924-6
  • Easterbrook PJ, Berlin J, Gopalan R, et al. Publication bias in clinical research. Lancet 1991;337:867-72
  • Valero A, Izquierdo I, Giralt J, et al. Rupatadine improves nasal symptoms, quality of life (ESPRINT-15) and severity in a subanalysis of a cohort of Spanish allergic rhinitis patients. J Investig Allergol Clin Immunol 2011;21:229-35

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.