272
Views
19
CrossRef citations to date
0
Altmetric
Research Article

Statin use in asthmatics on inhaled corticosteroids is associated with decreased risk of emergency department visits

, , , , , , & show all
Pages 685-693 | Accepted 30 Oct 2013, Published online: 18 Dec 2013

References

  • Third Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) 2002. Available at: http://www.nhlbi.nih.gov/guidelines/cholesterol/index.htm [last accessed 8 March 2013]
  • Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002;106:3143-421
  • Grundy SM, Cleeman JI, Merz CN, et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. J Am Coll Cardiol 2004;44:720-32
  • Standards of medical care in diabetes – 2012. Diabetes Care 2012;35(Suppl 1):S11-63
  • Smith SC Jr, Benjamin EJ, Bonow RO, et al. AHA/ACCF secondary prevention and risk reduction therapy for patients with coronary and other atherosclerotic vascular disease: 2011 update: a guideline from the American Heart Association and American College of Cardiology Foundation endorsed by the World Heart Federation and the Preventive Cardiovascular Nurses Association. J Am Coll Cardiol 2011;58:2432-46
  • Dinarello CA. Anti-inflammatory agents: present and future. Cell 2010;140:935-50
  • Hol J, Otterdal K, Breland UM, et al. Statins affect the presentation of endothelial chemokines by targeting to multivesicular bodies. PloS One 2012;7:e40673
  • Iwata A, Shirai R, Ishii H, et al. Inhibitory effect of statins on inflammatory cytokine production from human bronchial epithelial cells. Clin Exp Immunol 2012;168:234-40
  • Endres M. Statins: potential new indications in inflammatory conditions. Atherosclerosis Suppl 2006;7:31-5
  • Zeki AA, Kenyon NJ, Goldkorn T. Statin drugs, metabolic pathways, and asthma: a therapeutic opportunity needing further research. Drug Metab Lett 2011;5:40-4
  • Akinbami LJ, Moorman JE, Bailey C, et al. Trends in asthma prevalence, health care use, and mortality in the United States, 2001–2010. NCHS Data Brief 2012:1-8
  • Masoli M, Fabian D, Holt S, et al. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 2004;59:469-78
  • Hothersall EJ, Chaudhuri R, McSharry C, et al. Effects of atorvastatin added to inhaled corticosteroids on lung function and sputum cell counts in atopic asthma. Thorax 2008;63:1070-5
  • Cowan DC, Cowan JO, Palmay R, et al. Simvastatin in the treatment of asthma: lack of steroid-sparing effect. Thorax 2010;65:891-6
  • Maneechotesuwan K, Ekjiratrakul W, Kasetsinsombat K, et al. Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenase. J Allergy Clin Immunol 2010;126:754-62 e1
  • Braganza G, Chaudhuri R, McSharry C, et al. Effects of short-term treatment with atorvastatin in smokers with asthma – a randomized controlled trial. BMC Pulm Med 2011;11:16
  • Menzies D, Nair A, Meldrum KT, et al. Simvastatin does not exhibit therapeutic anti-inflammatory effects in asthma. J Allergy Clin Immunol 2007;119:328-35
  • Zeki AA, Franzi L, Last J, et al. Simvastatin inhibits airway hyperreactivity: implications for the mevalonate pathway and beyond. Am J Respir Crit Care Med 2009;180:731-40
  • Imamura M, Okunishi K, Ohtsu H, et al. Pravastatin attenuates allergic airway inflammation by suppressing antigen sensitisation, interleukin 17 production and antigen presentation in the lung. Thorax 2009;64:44-9
  • Zeki AA, Bratt JM, Rabowsky M, et al. Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling? Transl Res 2010;156:335-49
  • Chiba Y, Arima J, Sakai H, et al. Lovastatin inhibits bronchial hyperresponsiveness by reducing RhoA signaling in rat allergic asthma. Am J Physiol Lung Cell Mol Physiol 2008;294:L705-13
  • Ahmad T, Mabalirajan U, Sharma A, et al. Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from asymmetric dimethyl-arginine to asthma. Am J Respir Cell Mol Biol 2011;44:531-9
  • Huang CC, Chan WL, Chen YC, et al. Statin use in patients with asthma: a nationwide population-based study. Eur J Clin Invest 2011;41:507-12
  • Lokhandwala T, West-Strum D, Banahan BF, et al. Do statins improve outcomes in patients with asthma on inhaled corticosteroid therapy? A retrospective cohort analysis. BMJ Open 2012;2:1-7
  • Bonnet J, McPherson R, Tedgui A, et al. Comparative effects of 10-mg versus 80-mg atorvastatin on high-sensitivity C-reactive protein in patients with stable coronary artery disease: results of the CAP (Comparative Atorvastatin Pleiotropic effects) study. Clin Ther 2008;30:2298-313
  • Nissen SE, Nicholls SJ, Sipahi I, et al. Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial. JAMA 2006;295:1556-65
  • Szefler SJ, Chinchilli VM, Israel E, et al. Key observations from the NHLBI Asthma Clinical Research Network. Thorax 2012;67:450-5
  • Ahlbom A, Alfredsson L. Interaction: a word with two meanings creates confusion. Eur J Epidemiol 2005;20:563-4
  • Jha A, Basu S, Ryu M, et al. Simvastatin significantly augments impact of fluticasone on allergic airway inflammation and hyperreactivity in mice. Am J Respir Crit Care Med 2013;187:A4010
  • Zeki AA, Oldham J, Wilson M, et al. Statin use and asthma control in patients with severe asthma. BMJ Open 2013;3(8):1-10
  • Telenga ED, Tideman SW, Kerstjens HA, et al. Obesity in asthma: more neutrophilic inflammation as a possible explanation for a reduced treatment response. Allergy 2012;67:1060-8

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.