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Current Medical Research and Opinion Volume 30, 2014 - Issue 7
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Research Articles

Efficacy and safety of hydroxychloroquine in the treatment of type 2 diabetes mellitus: a double blind, randomized comparison with pioglitazone

Anil PareekMedical Affairs and Clinical Research, Ipca Laboratories Limited MumbaiIndiaCorrespondence[email protected]
,
Nitin ChandurkarClinical Research and Development, Ipca Laboratories Limited MumbaiIndia
,
Nihal ThomasDepartment of Endocrinology, Diabetes, and Metabolism, Christian Medical College VelloreIndia
,
Vijay ViswanathanMV Hospital for Diabetes and Diabetes Research Centre ChennaiIndia
,
Alaka DeshpandeDepartment of Medicine, Grant Medical College and Sir JJ Group of Hospitals MumbaiIndia;MGM University of Health Sciences Navi MumbaiIndia
,
O.P. GuptaDepartment of Medicine, MG Institute of Medical Sciences SewagramIndia
,
Asha ShahDepartment of Medicine, BJ Medical College and Civil Hospital AhmadabadIndia
,
Arjun KakraniDepartment of Medicine, Padmashree Dr DY Patil Medical College and Hospital PimpriIndia
,
Sudhir BhandariBhandari Clinic and Research Centre JaipurIndia
,
N.K. ThulasidharanDepartment of Medicine, Calicut Medical College and Hospital CalicutIndia
,
Banshi SabooDiacare-A Complete Diabetes Care and Hormone Clinic AhmadabadIndia
,
Shashidhar DevaramaniDepartment of Medicine, Shri BM Patil Medical College BijapurIndia
,
N.B. VijaykumarDepartment of Medicine, Andhra Medical College and KG Hospital VisakhapatnamIndia
,
Shrikant SharmaDepartment of Medicine, SMS Medical College and Hospital JaipurIndia
,
Navneet AgrawalDiabetes, Obesity, and Thyroid Centre GwaliorIndia
,
M. MaheshDepartment of Medicine, JSS Medical College and Hospital MysoreIndia
&
Kunal KothariDepartment of Medicine, MGM College and Hospital JaipurIndia
 show all
Pages 1257-1266 | Accepted 24 Mar 2014, Published online: 02 May 2014

References

  • UK Prospective Diabetes Study (UKPDS) Group. Intensive blood glucose control with sulfonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998;352:837-53
  • UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998;352:854-65
  • Negishi M, Shimomura K, Proks P, et al. Alpha glucosidase inhibitor voglibose can prevent pioglitazone-induced body weight gain in Type 2 diabetic patients. Br J Clin Pharmacol 2008;66:318-19
  • Karalliedde J, Buckingham R. Thiazolidinediones and their fluid-related adverse effects: facts, fiction and putative management strategies. Drug Saf 2007;30:741-53
  • Azoulay L, Yin H, Filion K, et al. The use of pioglitazone and the risk of bladder cancer in people with type 2 diabetes: nested case–control study. BMJ 2012;344:e3645
  • Wasko MC, Hubert HB, Lingala VB, et al. Hydroxychloroquine and risk of diabetes in patients with rheumatoid arthritis. JAMA 2007;298:187-93
  • Emami J, Gerstein HC, Pasutto FM, et al. Insulin-sparing effect of hydroxychloroquine in diabetic rat is concentration dependent. Can J Physiol Pharmacol 1999;77:118-23
  • Emami J, Pasutto F, Mercer JR, et al. Inhibition of insulin metabolism by hydroxychloroquine and its enantiomers in cytosolic fraction of liver homogenates from healthy and diabetic rats. Life Sci 1999;64:325-35
  • Quatraro A, Consoli G, Magno M, et al. Hydroxychloroquine in decompensated, treatment-refractory noninsulin-dependent diabetes mellitus: a new job for an old drug? Ann Intern Med 1990;112:678-81
  • Fessler B, Alarcon G, McGwin G, et al. Systemic lupus erythematosus in three ethnic groups: XVI. Association of hydroxychloroquine use with reduced risk of damage accrual. Arthritis Rheum 2005;52:1473-80
  • Penn S, Kao A, Schott L, et al. Hydroxychloroquine and glycemia in women with rheumatoid arthritis and systemic lupus erythematous. J Rheumatol 2010;37:1136-42
  • Gerstein HC, Thorpe KE, Taylor DW, et al. The effectiveness of hydroxychloroquine in patients with type 2 diabetes mellitus who are refractory to sulfonylureas – a randomized trial. Diabetes Res Clin Pract 2002;55:209-19
  • Pradhan AD, Manson JE, Rifai N, et al. C-reactive protein, interleukin-6, and risk of developing type-2 diabetes mellitus. JAMA 2001;286:327-34
  • Silva J, Mariz H, Rocha L, et al. Hydroxychloroquine decreases Th17-related cytokines in systemic lupus erythematosus and rheumatoid arthritis patients. Clinics 2013;68:766-71
  • Jessop JD, O’sullivan MM, Lewis PA, et al. A long-term five-year randomized controlled trial of hydroxychloroquine, sodium aurothiomalate, auranofin and penicillamine in the treatment of patients with rheumatoid arthritis. Br J Rheumatol 1998;37:992-1002
  • Mercer E, Rekedal L, Garg R, et al. Hydroxychloroquine improves insulin sensitivity in obese non-diabetic individuals. Arthritis Res Ther 2012;14:R135
  • Balaji V. Efficacy and safety of pioglitazone in type 2 diabetes in the Indian patients: results of an observational study. Indian J Endocrinol Metab 2013;17:709-15
  • Marmor M, Kelner U, Lai T, et al.; American Academy of Ophthalmology. Revised recommendations on screening for chloroquine and hydroxychloroquine retinopathy. Ophthalmology 2011;118:415-22
  • Aschner P, Katzeff H, Guo H, et al.; Sitagliptin Study 049 Group. Efficacy and safety of monotherapy of sitagliptin compared with metformin in patients with type 2 diabetes. Diabetes Obes Metab 2010;12:252-61
  • Williams-Herman D, Johnson J, Teng R, et al. Efficacy and safety of sitagliptin and metformin as initial combination therapy and as monotherapy over 2 years in patients with type 2 diabetes. Diabetes Obes Metab 2010;12:442-51
  • Williams-Herman D, Engel S, Round E, et al. Safety and tolerability of sitagliptin in clinical studies: a pooled analysis of data from 10,246 patients with type 2 diabetes. BMC Endocr Disord 2010;10:1-21
  • Rekedal L, Massarotti E, Garg R, et al. Changes in glycated hemoglobin after initiation of hydroxychloroquine or methotrexate in diabetic patients with rheumatic diseases. Arthritis Rheum 2010;62:3569-73
  • Krentz A, Bailey C. Oral anti-diabetic agents: Current role in type 2 diabetes mellitus. Drugs 2006;65:385-411
  • Dollery C. Therapeutic Drugs, 2nd edn. Edinburgh: Churchill Livingstone, 1999. H76

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