5,652
Views
17
CrossRef citations to date
0
Altmetric
Diabetes

Nutritional management of patients with diabetic peripheral neuropathy with L-methylfolate-methylcobalamin-pyridoxal-5-phosphate: results of a real-world patient experience trial

, , &
Pages 219-227 | Accepted 29 Sep 2015, Published online: 08 Dec 2015

References

  • Center for Disease Control and Prevention. National Diabetes Fact Sheet: National Estimates and General Information on Diabetes and Prediabetes in the United States, 2014. Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention, 2014
  • Diabetic Neuropathies: The Nerve Damage of Diabetes. Bethesda, MD: US Department of Health and Human Services; 2009 Feb. 12p. Report No.: NIH Publication No. 09–3185. Available at http://diabetes.niddk.nih.gov/dm/pubs/neuropathies/neuropathies.pdf. [Last accessed 12 May 2015]
  • Davies M, Brophy S, Williams R, Taylor A. The prevalence, severity, and impact of painful diabetic peripheral neuropathy in type 2 diabetes. Diabetes Care 2006;29:1518-22
  • Ziegler D. Painful diabetic neuropathy: advantage of novel drugs over old drugs? Diabetes Care 2009;32(Suppl 2):S414-19
  • Boulton AJM. Management of diabetic peripheral neuropathy. Clinical Diabetes 2005;23:9-15
  • De Vriese AS, Verbeuren TJ, de Voorde JV, et al. Endothelial dysfunction in diabetes. Br J Pharmacol 2000;130:963-74
  • Feldman EL, Vincent A. The prevalence, impact, and multifactorial pathogenesis of diabetic peripheral neuropathy. Adv Stud Med 2004;4:S642-9
  • Tesfaye S. Epidemiology and etiology of diabetic peripheral neuropathies. Adv Stud Med 2004;4:S1014-21
  • Sandireddy R, Yerra VG, Areti A, et al. Neuroinflammation and oxidative stress in diabetic neuropathy: futuristic strategies based on these targets. Int J Endocrinol 2014;2014:674987
  • Duby JJ, Campbell RK, Setter SM, et al. Diabetic neuropathy: an intensive review. Am J Health Syst Pharm 2004;61:160-73
  • Head KA. Peripheral neuropathy: pathogenic mechanisms and alternative therapies. Altern Med Rev 2005;11:294-329
  • van Etten RW, de Koning EJ, Verhaar MC, et al. Impaired NO-dependent vasodilation in patients with type II (non-insulin-dependent) diabetes mellitus is restored by acute administration of folate. Diabetologia 2002;457:1004-10
  • Jacobs AM, Cheng D. Management of diabetic small-fiber neuropathy with combination L-methylfolate, methylcobalamin, and pyridoxal 5’-phosphate. Rev Neurol Dis 2011;8:39-47
  • Shevalye H, Watcho P, Stavniichuk R, et al. Metanx alleviates multiple manifestations of peripheral neuropathy and increases intraepidermal nerve fiber density in Zucker diabetic fatty rats. Diabetes 2012;61: 2126-33
  • Miranda-Massari JR, Gonzalez MJ, Jimenez FJ, et al. Metabolic correction in the management of diabetic peripheral neuropathy: improving clinical results beyond symptom control. Curr Clin Pharmacol 2011;6: 260-73
  • Verhaar MC, Wever RMF, Kastelein JJP, et al. Effects of oral folic acid supplementation on endothelial function in familial hypercholesterolemia: a randomized placebo-controlled trial. Circulation 1999;100:335-8
  • Yilmaz M, Aktug H, Oltulu F, Erbas O. Neuroprotective effects of folic acid on experimental diabetic peripheral neuropathy. Toxicol Ind Health 2013 Dec 5. [Epub ahead of print], published online, doi: 10.1177/0748233713511513
  • Yaqub BA, Siddique A, Sulimani R. Effects of methylcobalamin on diabetic neuropathy. Clin Neurol Neurosurg 1992;94:105-11
  • Watanabe T, Kaji R, Oka N, et al. Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 1994;122:140-3
  • Jian-bo L, Cheng-ya W, Jia-wei C, et al. The preventive efficacy of methylcobalamin on rat peripheral neuropathy influenced by diabetes via neural IGF-1 levels. Nutr Neurosci 2010;13:79-86
  • Jain SK, Lim G. Pyridoxine and pyridoxamine inhibits superoxide radicals and prevents lipid peroxidation, protein glycosylation, and (Na+ + K+)-ATPase activity reduction in high glucose-treated human erythrocytes. Free Radical Biol Med 2001;30:232-7
  • Walker MJ, Morris LM, Cheng D. Improvement of cutaneous sensitivity in diabetic peripheral neuropathy with combination L-methylfolate, methylcobalamin, and pyridoxal 5-phosphate. Rev Neurol Dis 2010;7:132-9
  • Farvid MS, Homayouni F, Amiri Z, Adelmanesh F. Improving neuropathy scores in type 2 diabetic patients using micronutrients supplementation. Diabetes Res Clin Pract 2011;93:86-94
  • Jacobs, AM, Cheng D. Addition of Metanx in pregabalin partial responders for painful diabetic neuropathy. J Diab Mellitus 2013;3:134-8
  • Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: a randomized trial. Am J Med 2013;126:141-9
  • Bastyr EJ III, Price KL, Bril V; for the MBBQ Study Group. Development and validity testing of the neuropathy total symptom score-6: questionnaire for the study of sensory symptoms of diabetic peripheral neuropathy. Clin Ther 2005;27:1278-94
  • Currie C, Covington M, McEwan P, et al. Diabetic peripheral neuropathy: evaluation of the association between neuropathic symptoms (NTSS-6-SA) and health related utility (EQ5D). Value Health 2005;8:A172-3
  • Sadosky A, Schaefer C, Mann R, et al. Burden of illness associated with painful diabetic peripheral neuropathy among adults seeking treatment in the US: results from a retrospective chart review and cross-sectional survey. Diabetes Metab Syndr Obes 2013;6:79-92
  • Gore M, Brandenburg NA, Hoffman DL, et al. Burden of illness in painful diabetic peripheral neuropathy: the patients’ perspectives. J Pain 2006;7:892-900
  • Tölle T, Xu X, Sadosky AB. Painful diabetic neuropathy: a cross-sectional survey of health state impairment and treatment patterns. J Diabetes Complications 2006;20:26-33
  • Sadosky A, Hopper J, Parsons B. Painful diabetic peripheral neuropathy: results of a survey characterizing the perspectives and misperceptions of patients and healthcare practitioners. Patient 2014;7:107-14
  • Perrin NA, Nichols GA, Oglesby A, Bastyr EJ. The reliability and validity of a self-administered version of the neuropathy total symptom score-6-SA (NTSS-6-SA). Diabetologia 2004;47(Suppl 1):A35

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.