Section A The pharmacology of lorazepam, a broad-spectrum tranquillizer

References

• Childress, S. J., and Gluckman, M. I., (1964). 1, 4-Benzodiazepines. J. pharm. Sci., 53, 577–590.1. Childress, S. J., and Gluckman, M. I., (1964). 1, 4-Benzodiazepines. J. pharm. Sci., 53, 577–590.
   PubMed Web of Science ®Google Scholar
• Bell, S. C., McCaully, R. J., Gochman, C., Childress, S. J., and Gluckman, M. I., (1968). 3-Substituted-l, 4-Benzodiazepin-2-ones. J. med. Chem., 11, 457–461.2. Bell, S. C., McCaully, R. J., Gochman, C., Childress, S. J., and Gluckman, M. I., (1968). 3-Substituted-l, 4-Benzodiazepin-2-ones. J. med. Chem., 11, 457–461.
   PubMed Web of Science ®Google Scholar
• Elliott, H. W., Normof, N., Navarro, G., and Comer, W. H., (1969). Evaluation of safety and efficacy of the hypnotic-sedative Wy 4036. Presented at VIth Annual Meeting of American Society of Clinical Pharmacology and ChemotherapyAtlantic City, New Jersey.3. Elliott, H. W., Normof, N., Navarro, G., and Comer, W. H., (1969). Evaluation of safety and efficacy of the hypnotiosedative Wy 4036. Presented at VIth Annual Meeting of American Society of Clinical Pharmacology and Chemotherapy, Atlantic City, New Jersey.
   Google Scholar
• Norton, M. L., (1969). Preliminary evaluation of the new hypnotic-sedative, Wy 4036. Presented at 14th Annual Scientific Session of Michigan Society of Anaesthesiology, Detroit, Michigan.4. Norton, M. L., (1969). Preliminary evaluation of the new hypnotic-sedative, Wy 4036. Presented at 14th Annual Scientific Session of Michigan Society of Anaesthesiology, Detroit, Michigan.
   Google Scholar
• Norris, W., (1971). Wy 4036 (lorazepam) - a study of its use in pre-medication. Brit. J. Anaesth., 43, 785–9.5. Norris, W., (1971). Wy 4036 (lorazepam) - a study of its use in pre-medication. Brit. J. Anaesth., 43, 785–9.
   PubMed Web of Science ®Google Scholar
• Haider, I., (1971). Evaluation of a new tranquillizer - Wy 4036 - in the treatment of anxiety. Brit. J. Psychiat., 119, 597–598.6. Haider, I., (1971). Evaluation of a new tranquillizer - Wy 4036 - in the treatment of anxiety. Brit. J. Psychiat., 119, 597–598.
   PubMed Web of Science ®Google Scholar
• Hedges, A., Turner, P., and Harry, T. V. A., (1971). Preliminary studies on the central effects of lorazepam, a new benzodiazepine. J. clin. Pharmac., 11, 423–427.7. Hedges, A., Turner, P., and Harry, T. V. A., (1971). Preliminary studies on the central effects of lorazepam, a new benzodiazepine. J. clin. Pharmac., 11, 423–427.
   Web of Science ®Google Scholar
• Gluckman, M. I., (1971). Pharmacology of 7-chloro-5-(o-chlorophenyl)-1, 3-dihydro-3-hydroxy-2H-1, 4-benzodiazepin-2-one (lorazepam; Wy 4036). Arzneim.-forsch., 21, 1049–55.8. Gluckman, M. I., (1971). Pharmacology of 7-chloro-5-(o-chlorophenyl)-1, 3-dihydro-3-hydroxy-2H-1, 4-benzodiazepin-2-one (lorazepam; Wy 4036). Arzneim.-forsch., 21, 1049–55.
   PubMed Web of Science ®Google Scholar
• Stein, L., and Berger, B., (1971). Psychopharmacology of 7-chloro-5-(o-chlorophenyl)-1, 3-dihydro-3-hydroxy-2H-1, 4-benzodiazepin-2-one (lorazepam) in squirrel monkey and rat. Arzneim. -forsch., 21, 1073–8.9. Stein, L., and Berger, B., (1971). Psychopharmacology of 7-chloro-5-(o-chlorophenyl)-1, 3-dihydro-3-hydroxy-2H-1, 4-benzodiazepin-2-one (lorazepam) in squirrel monkey and rat. Arzneim. -forsch., 21, 1073–8.
   PubMed Web of Science ®Google Scholar
• Southgate, P. J., and Wilson, A. B., (1971). Pharmacological interaction of lorazepam with thiopentone sodium and skeletal neuromuscular blocking drugs. Brit. J. Pharmac., 43, 434P–435P.10. Southgate, P. J., and Wilson, A. B., (1971). Pharmacological interaction of lorazepam with thiopentone sodium and skeletal neuromuscular blocking drugs. Brit. J. Pharmac., 43, 434P–435P.
   PubMed Web of Science ®Google Scholar
• Everett, G. M., and Richards, R. K., (1944). Comparative anticonvulsive action of 3, 5, -5-trimethyloxazolidine-2, 4-dione (tridione), dilantin and phenobarbital. J. Pharmacol. exp. Ther., 81, 402–407.11. Everett, G. M., and Richards, R. K., (1944). Comparative anticonvulsive action of 3, 5, -5-trimethyloxazolidine-2, 4-dione (tridione), dilantin and phenobarbital. J. Pharmacol. exp. Ther., 81, 402–407.
   Google Scholar
• Swinyard, E. A., Brown, W. C., and Goodman, L. S., (1952). Comparative assays of anti-epileptic drugs in mice and rats. J. Pharmacol. exp. Ther., 106, 319–330.12. Swinyard, E. A., Brown, W. C., and Goodman, L. S., (1952). Comparative assays of anti-epileptic drugs in mice and rats. J. Pharmacol. exp. Ther., 106, 319–330.
   PubMed Web of Science ®Google Scholar
• Gluckman, M. I., (1965). Pharmacology of oxazepam (Serax), a new anti-anxiety agent. Curr. ther. Res., 7, 721–40.13. Gluckman, M. I., (1965). Pharmacology of oxazepam (Serax), a new anti-anxiety agent. Curr. ther. Res., 7, 721–40.
   PubMed Web of Science ®Google Scholar
• Tedeschi, R. E., Tedeschi, D. H., Mucha, A., Cook, L., Mattis, P. A., and Fellows, E. J., (1959). Effects of various centrally acting drugs on fighting behaviour of mice. J. Pharmacol. exp. Ther., 125, 28–34.14. Tedeschi, R. E., Tedeschi, D. H., Mucha, A., Cook, L., Mattis, P. A., and Fellows, E. J., (1959). Effects of various centrally acting drugs on fighting behaviour of mice. J. Pharmacol. exp. Ther., 125, 28–34.
   PubMed Web of Science ®Google Scholar
• Geller, I., and Seifter, J., (1960). The effects of meprobamate, barbiturates, d-amphetamine and promazine on experimentally induced conflict in the rat. Psychopharmacologia (Berl.), 1, 482–492.15. Geller, I., and Seifter, J., (1960). The effects of meprobamate, barbiturates, d-amphetamine and promazine on experimentally induced conflict in the rat. Psychopharmacologia (Berl.), 1, 482–492.
   Web of Science ®Google Scholar
• D'Amour, F. E., and Smith, D. L., (1941). Method for determining loss of pain sensation. J. Pharmacol. exp. Ther., 72, 74–79.16. D'Amour, F. E., and Smith, D. L., (1941). Method for determining loss of pain sensation. J. Pharmacol. exp. Ther., 72, 74–79.
   Google Scholar
• Gaddum, J. H., (1959). Pharmacology, 5th Edn., Oxford University Press. 504.17. Gaddum, J. H., (1959). Phurmucology, 5th Edn., Oxford University Press. p.504.
   Google Scholar
• Haffner, F., (1929). Experimentelle Prufung Scmerzstillender Mittel. Dtsch. med. Wschr., 55, 731–733.18. Haffner, F., (1929). Experimentelle Prufung Scmerzstillender Mittel. Dtsch. med. Wschr., 55, 731–733.
   Google Scholar
• Owen, G., Hatfield, G. K., Pollock, J. J., Steinberg, A. J., Tucker, W. E., and Agersborg, H. P. K. Jr., (1971). Toxicity studies of lorazepam, anew benzodiazepine, in animals. Arzneim.-forsch., 21, 1065–1073.19. Owen, G., Hatfield, G. K., Pollock, J. J., Steinberg, A. J., Tucker, W. E., and Agersborg, H. P. K. Jr., (1971). Toxicity studies of lorazepam, anew benzodiazepine, in animals. Arzneim.-forsch., 21, 1065–1073.
   PubMed Web of Science ®Google Scholar
• Geller, I., (1964). Relative potencies of benzodiazepines as measured by their effects on conflict behaviour. Arch. int. Pharmacodyn., 149, 243–7.20. Geller, I., (1964). Relative potencies of benzodiazepines as measured by their effects on conflict behaviour. Arch. int. Pharmacodyn., 149, 243–7.
   PubMedGoogle Scholar
• Randall, L. O., Heise, G. A., Schallek, W., Bagdon, R. E., Banziger, R., Boris, A., Moe, R. A., and Abrams, W. B., (1961). Pharmacological and clinical studies on Valium (T.M.), a new psychotherapeutic agent of the benzodiazepine class. Curr. ther. Res., 3, 405–25.21. Randall, L. O., Heise, G. A., Schallek, W., Bagdon, R. E., Banziger, R., Boris, A., Moe, R. A., and Abrams, W. B., (1961). Pharmacological and clinical studies on Valium (T.M.), a new psychotherapeutic agent of the benzodiazepine class. Curr. ther. Res., 3, 405–25.
   PubMed Web of Science ®Google Scholar
• Preston, J. B., (1956). Effects of chlorpromazine on central nervous system of cat: possible neural basis for action. J. Pharmacol. exp. Ther., 118, 100–115.22. Preston, J. B., (1956). Effects of chlorpromazine on central nervous system of cat: possible neural basis for action. J. Pharmacol. exp. Ther., 118, 100–115.
   PubMed Web of Science ®Google Scholar
• Killam, E. K., Killam, K. F., and Shaw, T., (1957). The effects of psychotherapeutic compounds on central afferent and limbic pathways. Ann. N. Y. Acad. Sci., 66, 784–805.23. Killam, E. K., Killam, K. F., and Shaw, T., (1957). The effects of psychotherapeutic compounds on central afferent and limbic pathways. Ann. N. Y. Acad. Sci., 66, 784–805.
   PubMed Web of Science ®Google Scholar
• Essig, C. F., and Carter, W. W., (1957). Convulsions and bizarre behaviour in monkeys receiving chlorpromazine. Proc. Soc. exp. Biol. Med., 95, 726–9.24. Essig, C. F., and Carter, W. W., (1957). Convulsions and bizarre behaviour in monkeys receiving chlorpromazine. Proc. Soc. exp. Biol. Med., 95, 726–9.
   PubMed Web of Science ®Google Scholar
• Collard, J., (1971). Initial psychopharmacological study of lorazepam (Wy 4036). Arzneim.-forsch., 21, 1091–1095.25. Collard, J., (1971). Initial psychopharmacological study of lorazepam (Wy 4036). Arzneim.-forsch., 21, 1091–1095.
   PubMed Web of Science ®Google Scholar
• Feldman, S. A., and Crawley, B. E., (1970). Diazepam and muscle relaxants. Brit. med. J., 1, 691.26. Feldman, S. A., and Crawley, B. E., (1970). Diazepam and muscle relaxants. Brit. med. J., 1, 691.
   PubMed Web of Science ®Google Scholar
• Feldman, S. A., and Crawley, B. E., (1970). Interaction of diazepam with the muscle relaxant drugs. Brit. med. J., 2, 336–338.27. Feldman, S. A., and Crawley, B. E., (1970). Interaction of diazepam with the muscle relaxant drugs. Brit. med. J., 2, 336–338.
   PubMed Web of Science ®Google Scholar
• Dretchen, K., Ghonheim, M. M., and Long, J. P., (1971). The interaction of diazepam with myoneural blocking agents. Anaesthesiology, 34, 463–468.28. Dretchen, K., Ghonheim, M. M., and Long, J. P., (1971). The interaction of diazepam with myoneural blocking agents. Anaesthesiology, 34, 463–468.
   PubMed Web of Science ®Google Scholar
• Weil, C. S., (1952). Tables for convenient calculation of median effective dose (LD50 or ED50) and instructions in their use. Biometrics, 8, 249–263.29. Weil, C. S., (1952). Tables for convenient calculation of median effective dose (LD50 or ED50) and instructions in their use. Biometrics, 8, 249–263.
   Web of Science ®Google Scholar