13
Views
8
CrossRef citations to date
0
Altmetric
Research Article

Clinical studies on alclofenac in the treatment of rheumatic diseases: a drug in question

, M.D., B.Sc, M.R.C.S.
Pages 274-285 | Accepted 06 Jun 1975, Published online: 05 Aug 2008

Reference

  • American Rheumatism Association Co-operating Clinics Committee, (1967). A 3-month trial of indomethacin in rheumatoid arthritis with special reference to analysis and inference. Clin. Pharm. Therap., 2, 7.1. American Rheumatism Association Co-operating Clinics Committee, (1967). A 3-month trial of indomethacin in rheumatoid arthritis with special reference to analysis and inference. Clin. Pharm. Therap., 2, 7.
  • Aylward, M., (1975). Personal communication to Berk Pharmaceuticals Ltd.2. Aylward, M., (1975). Personal communication to Berk Pharmaceuticals Ltd.
  • Aylward, M., (1975). A review of possible mechanisms of action of the antirheumatic drug, alclofenac. Curr. med. Res. Opin., 3, 249.3. Aylward, M., (1975). A review of possible mechanisms of action of the antirheumatic drug, alclofenac. Curr. med. Res. Opin., 3, 249.
  • Aylward, M., and Davies, D. B. S., (1972). A double-blind crossover trial comparing a new antirheumatic agent alclofenac with phenylbutazone in chronic rheumatic disorders. Brit. J. clin. Pract., 26, 517.4. Aylward, M., and Davies, D. B. S., (1972). A double-blind crossover trial comparing a new antirheumatic agent alclofenac with phenylbutazone in chronic rheumatic disorders. Brit. J. clin. Pract., 26, 517.
  • Aylward, M., and Maddock, J., (1973). Total and free plasma tryptophan concentrations in rheumatoid disease. J. Pharm. Pharmacol., 25, 570.5. Aylward, M., and Maddock, J., (1973). Total and free plasma tryptophan concentrations in rheumatoid disease. J. Pharm. Pharmacol., 25, 570.
  • Aylward, M., Maddock, J., and Parker, R. J., (1974). Studies on 4-allyloxy-3-chlorophenyl-acetic acid (alclofenac). A double-blind comparison of alclofenac and aspirin in rheumatoid arthritis and effects of therapy on serum immunoglobulins and rheumatoid factor. Ann. rheum. Dis., 33, 268.6. Aylward, M., Maddock, J., and Parker, R. J., (1974). Studies on 4-allyloxy-3-chlorophenyl-acetic acid (alclofenac). A double-blind comparison of alclofenac and aspirin in rheumatoid arthritis and effects of therapy on serum immunoglobulins and rheumatoid factor. Ann. rheum. Dis., 33, 268.
  • Aylward, M., Maddock, J., Wheeldon, R., and Parker, R. J., (1975). A study of the influence of various antirheumatic drug regimens on serum acute-phase proteins, plasma tryptophan, and erythrocyte sedimentation rate in rheumatoid arthritis. Rheumatol. Rehabil, 14, 101.7. Aylward, M., Maddock, J., Wheeldon, R., and Parker, R. J., (1975). A study of the influence of various antirheumatic drug regimens on serum acute-phase proteins, plasma tryptophan, and erythrocyte sedimentation rate in rheumatoid arthritis. Rheumatol. Rehabil, 14, 101.
  • Aylward, M., Parker, R. J., Holly, F., Maddock, J., and Davies, D. B. S., (1975). Long-term study of indomethacin and alclofenac in treatment of rheumatoid arthritis. Brit. med. J., 2, 79.8. Aylward, M., Parker, R. J., Holly, F., Maddock, J., and Davies, D. B. S., (1975). Long-term study of indomethacin and alclofenac in treatment of rheumatoid arthritis. Brit. med. J., 2, 79.
  • Bedi, S. S., (1975). A double-blind comparison of alclofenac and aspirin in the treatment of rheumatoid arthritis. Part II: high dosage regime for assessment of analgesic and anti-inflammatory property. Curr. med. Res. Opin., 3, 309.9. Bedi, S. S., (1975). A double-blind comparison of alclofenac and aspirin in the treatment of rheumatoid arthritis. Part II: high dosage regime for assessment of analgesic and anti-inflammatory property. Curr. med. Res. Opin., 3, 309.
  • Beecher, H. K., (1959). The measurement of pain. Science, 130, 267.10. Beecher, H. K., (1959). The measurement of pain. Science, 130, 267.
  • Boardman, P. L., and Hart, F. D., (1967). Clinical measurement of the anti-inflammatory effects of salicylate in rheumatoid arthritis. Brit. med. J., 4, 264.11. Boardman, P. L., and Hart, F. D., (1967). Clinical measurement of the anti-inflammatory effects of salicylate in rheumatoid arthritis. Brit. med. J., 4, 264.
  • Buu-Hoi, N. P., Lambelin, G., Gillet, C, Roba, J., and Staquet, M., (1969). 4-alIyloxy-3-chlorophenylacetic acid, a new type of analgesic, antipyretic and antiphlogistic drug. Natur-wiss., 56, 330.12. Buu-Hoi, N. P., Lambelin, g., Gillet, C, Roba, J., and Staquet, M., (1969). 4-alIyloxy-3-chlorophenylacetic acid, a new type of analgesic, antipyretic and antiphlogistic drug. Natur-wiss., 56, 330.
  • Chamberlain, M. A., and Wright, V., (1975). A double-blind trial to assess the value of alclofenac compared with phenylbutazone in the management of rheumatoid arthritis. Ann. rheum. Dis., 34, 186.13. Chamberlain, M. A., and Wright, V., (1975). A double-blind trial to assess the value of alclofenac compared with phenylbutazone in the management of rheumatoid arthritis. Ann. rheum. Dis., 34, 186.
  • Colinet, E., and Famaey, J. P., (1971). Etude clinique de l'alclofénac en rhumatologie. Etude co-opérative. J. Beige Med. phys. Rhum., 26, 267.14. Colinet, E., and Famaey, J. P., (1971). Etude clinique de l'alclofénac en rhumatologie. Etude co-opérative. J. Beige Med. phys. Rhum., 26, 267.
  • Currey, H. L. F., Harris, J., Mason, R. M., Woodland, J., Beveridge, T., Roberts, C. J., Vere, D. W., Dixon, St. A., Davies, J. J., and Owen-Smith, B., (1974). Comparison of azathioprine, cyclophosphamide and gold in treatment of rheumatoid arthritis. Brit. med. J., 3, 763.15. Currey, H. L. F., Harris, J., Mason, R. M., Woodland, J., Beveridge, T., Roberts, C. J., Vere, D. W., Dixon, St. A., Davies, J. J., and Owen-Smith, B., (1974). Comparison of azathioprine, cyclophosphamide and gold in treatment of rheumatoid arthritis. Brit. med. J., 3, 763.
  • Day, A. T., Golcling, J. R., Lee, P. N., and Butterworth, A. D., (1974). Penicillamine in rheumatoid disease: a long-term study. Brit. med. J., 1, 180.16. Day, A. T., Golcling, J. R., Lee, P. N., and Butterworth, A. D., (1974). Penicillamine in rheumatoid disease: a long-term study. Brit. med. J., 1, 180.
  • Deodhar, S. D., Dick, W. C., Hodgkinson, R., and Buchanan, W. W., (1973). Measurement of clinical response to anti-inflammatory drug therapy in rheumatoid arthritis. Quart. J. Med., (N.S.), 42, 387.17. Deodhar, S. D., Dick, W. C., Hodgkinson, R., and Buchanan, W. W., (1973). Measurement of clinical response to anti-inflammatory drug therapy in rheumatoid arthritis. Quart. J. Med., (N.S.), 42, 387.
  • Desproges-Gotteron, R., Leroy, V., and Comte, B., (1971). A double-blind comparison of alclofenac and indomethacin in osteoarthritis of the hip. Curr. ther. Res., 13, 393.18. Desproges-Gotteron, R., Leroy, V., and Comte, B., (1971). A double-blind comparison of alclofenac and indomethacin in osteoarthritis of the hip. Curr. ther. Res., 13, 393.
  • Donnelly, P., Lloyd, K., and Campbell, H., (1967). Indomethacin in rheumatoid arthritis: an evaluation of its anti-inflammatory and side-effects. Brit. med. J., 1, 69.19. Donnelly, P., Lloyd, K., and Campbell, H., (1967). Indomethacin in rheumatoid arthritis: an evaluation of its anti-inflammatory and side-effects. Brit. med. J., 1, 69.
  • Council, Empire Rheumatism, (1955). Multi-centre controlled trial comparing cortisone acetate and acetylsalicylic acid in long-term treatment of rheumatoid arthritis. Ann. rheum. Dis., 14, 353.20. Council, Empire Rheumatism, (1955). Multi-centre controlled trial comparing cortisone acetate and acetylsalicylic acid in long-term treatment of rheumatoid arthritis. Ann. rheum. Dis., 14, 353.
  • Fairley, K. F., Barrie, J. V., and Johnson, W., (1972). Sterility and testicular atrophy related to cyclophosphamide therapy. Lancet, 1, 568.21. Fairley, K. F., Barrie, J. V., and Johnson, W., (1972). Sterility and testicular atrophy related to cyclophosphamide therapy. Lancet, 1, 568.
  • Hart, F. D., (1970). Antirheumatic remedies. Practitioner, 205, 597.22. Hart, F. D., (1970). Antirheumatic remedies. Practitioner, 205, 597.
  • Hort, J. F., (1975). Adverse reactions to alclofenac. Curr. med. Res. Opin., 3, 333.23. Hort, J. F., (1975). Adverse reactions to alclofenac. Curr. med. Res. Opin., 3, 333.
  • Jaffé, G., (1974). A double-blind, between-patient comparison of alclofenac (‘Prinalgin’) and indomethacin in the treatment of low back pain and sciatica. Curr. med. Res. Opin., 2, 424.24. Jaffé, g., (1974). A double-blind, between-patient comparison of alclofenac (‘Prinalgin’) and indomethacin in the treatment of low back pain and sciatica. Curr. med. Res. Opin., 2, 424.
  • Klemm, C, (1971). Evaluation of alclofenac in the treatment of rheumatic diseases. Z. rheumaforsch., 30, 17.25. Klemm, C, (1971). Evaluation of alclofenac in the treatment of rheumatic diseases. Z. rheumaforsch., 30, 17.
  • Kumar, R., Biggart, J. D., Mc Evoy, J., and Mc Geown, M. g., (1972). Cyclophosphamide and reproductive function. Lancet, 1, 1212.26. Kumar, R., Biggart, J. D., Mc Evoy, J., and Mc Geown, M. g., (1972). Cyclophosphamide and reproductive function. Lancet, 1, 1212.
  • Lambelin, G., Roba, J., Gillet, C, and Buu-Hoi, N. P., (1970). Pharmacology of a new analgesic, antipyretic and anti-inflammatory agent: 4-allyloxy-3-chlorophenylacetic acid. Arzneim.-forsch., 20, 610.27. Lambelin, g., Roba, J., Gillet, C, and Buu-Hoi, N. P., (1970). Pharmacology of a new analgesic, antipyretic and anti-inflammatory agent: 4-allyloxy-3-chlorophenylacetic acid. Arzneim.-forsch., 20, 610.
  • Maddock, J., Rees, P., Holly, F., and Aylward, M., (1975). The influence of alclofenac treatment on acute-phase proteins, plasma tryptophan, and erythrocyte sedimentation rate in patients with rheumatoid arthritis. Curr. med. Res. Opin., 3, 286.28. Maddock, J., Rees, P., Holly, F., and Aylward, M., (1975). The influence of alclofenac treatment on acute-phase proteins, plasma tryptophan, and erythrocyte sedimentation rate in patients with rheumatoid arthritis. Curr. med. Res. Opin., 3, 286.
  • Mansel-Jones, D., (1974). Adverse reactions to alclofenac. Brit. med. J., 1, 160.29. Mansel-Jones, D., (1974). Adverse reactions to alclofenac. Brit. med. J., 1, 160.
  • Mc Arthur, J. N., and Dawkins, P. D., (1969). Displacement of small endogenous molecules from their protein bincling sites by anti-inflammatory drugs. J. Pharm. Pharmacol., 21, 744.30. Mc Arthur, J. N., and Dawkins, P. D., (1969). Displacement of small endogenous molecules from their protein bincling sites by anti-inflammatory drugs. J. Pharm. Pharmacol., 21, 744.
  • Mc Conkey, B., Crockson, R. A., and Crockson, A. P., (1972). The assessment of rheumatoid arthritis. Quart. J. Med., (N.S.), 41, 115.31. Mc Conkey, B., Crockson, R. A., and Crockson, A. P., (1972). The assessment of rheumatoid arthritis. Quart. J. Med., (N.S.), 41, 115.
  • Mc Conkey, B., Crockson, R. A., Crockson, A. P., and Wilkinson, A. R., (1973). Effects of some anti-inflammatory drugs in rheumatoid arthritis. Quart. J. Med. (N.S.), 42, 785.32. Mc Conkey, B., Crockson, R. A., Crockson, A. P., and Wilkinson, A. R., (1973). Effects of some anti-inflammatory drugs in rheumatoid arthritis. Quart. J. Med. (N.S.), 42, 785.
  • Medical Research Council and Nuffield Foundation, (1959). Clinical trials of cortisone, ACTH, and other therapeutic measures in rheumatoid disease. Ann. rheum. Dis., 18, 173.33. Medical Research Council and Nuffield Foundation, (1959). Clinical trials of cortisone, ACTH, and other therapeutic measures in rheumatoid disease. Ann. rheum. Dis., 18,173.
  • Medical Research Council and Nuffield Foundation, (1960). Final report on clinical trials of cortisone, ACTH, and other therapeutic measures in rheumatoid disease. Ann. rheum. Dis., 19, 331.34. Medical Research Council and Nuflield Foundation, (1960). Final report on clinical trials of cortisone, ACTH, and other therapeutic measures in rheumatoid disease. Ann. rheum. Dis., 19, 331.
  • McLean Baird, I., (1972). An assessment of gastro-intestinal bleecling using alclofenac compared with aspirin, Personal communication.35. McLean Baird, I., (1972). An assessment of gastro-intestinal bleecling using alclofenac compared with aspirin, Personal communication.
  • Ory, M., (1971). Etude clinique de l' alclofénac orale et parenterale dans des affections rhumatismales aigues. Brux.-méd., 51, 615.36. Ory, M., (1971). Etude clinique de l' alclofénac orale et parenterale dans des affections rhumatismales aigues. Brux.-méd., 51, 615.
  • Pavelka, K., Vojtišek, O., Brémová, A., Kaková, D., and Handlová, D, (1973). Double-blind comparison of alclofenac and phenylbutazone in the short-term treatment of rheumatoid arthritis. Curr. med. Res. Opin., 1, 342.37. Pavelka, K., Vojtišek, O., Brémová, A., Kaková, D., and Handlová, D, (1973). Double-blind comparison of alclofenac and phenylbutazone in the short-term treatment of rheumatoid arthritis. Curr. med. Res. Opin., 1, 342.
  • Roncucci, R., Simon, M-J., Gillet, C, Lambelin, G., and Kaisin, M., (1972). Characterisation of alclofenac metabolites in various animal species.. In “In Proceeclings of the International Symposium on Gas Chromatography/Mass Spectrometry, Elba, Italy”. Ed. A. Frigerio, p.431. Tamburini, Milan.38. Roncucci, R., Simon, M-J., Gillet, C., Lambelin, g., and Kaisin, M., (1972). Characterisation of alclofenac metabolites in various animal species. In “Proceedings of the International Symposium on Gas Chromatography/Mass Spectrometry, Elba, Italy”. Ed. A. Frigerio, p.431. Tamburini, Milan.
  • Spector, W. g., and Willoughby, D. A., (1968). “Pharmacology of Inflammation.” English Universities Press, London.39. Spector, W. g., and Willoughby, D. A., (1968). “Pharmacology of Inflammation.” English Universities Press, London.
  • Thomas, G. M., Rees, P., Dippy, J. R., and Maddock, J., (1975). Simultaneous pharmacokinetics of alclofenac in plasma and synovial fluid in patients with rheumatoid arthritis. Curr. med. Res. Opin., 3, 264.40. Thomas, g. M., Rees, P., Dippy, J. R., and Maddock, J., (1975). Simultaneous pharmacokinetics of alclofenac in plasma and synovial fluid in patients with rheumatoid arthritis. Curr. med. Res. Opin., 3, 264.
  • U.K. Multicentre Trial Group, (1973). Controlled trial of D-penicillamine in severe rheumatoid arthritis. Lancet, 1, 275.41. U.K. Multicentre Trial Group, (1973). Controlled trial of D-penicillamine in severe rheumatoid arthritis. Lancet, 1,275.
  • Van Hoek, J., (1970). A comparison of alclofenac and indomethacin in the treatment of coxarthrosis. Curr. ther. Res., 12, 551.42. Van Hoek, J., (1970). A comparison of alclofenac and indomethacin in the treatment of coxarthrosis. Curr. ther. Res., 12, 551.
  • Wiggins, L. F., and Aylward, M., (1973). Controlled studies with the most currently used antirheumatic drugs. Abstr. XIII Int. Congress of Rheumatology, Kyoto, Japan. Excerpta Medica, Amsterdam, Int. Cong. Ser. No. 299, p.165. 43. Wiggins, L. F., and Aylward, M., (1973). Controlled studies with the most currently used antirheumatic drugs. Abstr. XIII Int. Congress of Rheumatology, Kyoto, Japan. Excerpta Medica, Amsterdam, Int. Cong. Ser. No. 299, p.165.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.