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Research Article

Clinical evaluation of two daily doses of naproxen and indomethacin: result of a double-blind crossover trial

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Pages 359-366 | Received 24 Jun 1975, Published online: 07 Aug 2008

Reference

  • Beck E. R. Naproxen (Naprosyn) and gastro-intestinal haemorrhage. Brit. med. J. 1974; 1: 5721. Beck E. R. Naproxen (Naprosyn) and gastro-intestinal haemorrhage. Brit. med. J. 1974; 1: 572
  • Brogden R. N., Pinder R. M., Sawyer P. R., Speight T. M., Avery G. S. Naproxen: a review of its pharmacological properties and therapeutic efficacy and use. Drugs 1975; 9: 3262. Brogden R. N., Pinder R. M., Sawyer P. R., Speight T. M., Avery G. S. Naproxen: a review of its pharmacological properties and therapeutic efficacy and use. Drugs 1975; 9: 326
  • Chaplin M. D., Roszkowski A. P., Richards R. K. Displacement of thiopental (TP) from plasmaproteins by naproxen (D-2 (6′methoxy-2′-naphthyl)-propionic acid). Pharmacologist 1970; 12: 2443. Chaplin M. D., Roszkowski A. P., Richards R. K. Displacement of thiopental (TP) from plasmaproteins by naproxen (D-2 (6′methoxy-2′-naphthyl)-propionic acid). Pharmacologist 1970; 12: 244
  • Cuthbert M. F. Adverse reactions to non-steroidal antirheumatic drugs. Curr. med. Res. Opin. 1974; 2: 6004. Cuthbert M. F. Adverse reactions to non-steroidal antirheumatic drugs. Curr. med. Res. Opin. 1974; 2: 600
  • Deodhar S. D., Dick W. C., Hodgkinson R., Buchanan W. W. Measurement of clinical response to anti-inflammatory drug therapy in rheumatoid arthritis. Quart. J. Med. 1973; 42: 3875. Deodhar S. D., Dick W. C., Hodgkinson R., Buchanan W. W. Measurement of clinical response to anti-inflammatory drug therapy in rheumatoid arthritis. Quart. J. Med. 1973; 42: 387
  • Diamond H., Alexander S., Kuzell W., Lussier A., Odone D., Tompkins R. A multi-center double-blind crossover comparison study of naproxen and aspirin in patients with rheumatoid arthritis. Scand.J. Rheumatol., Suppl. 1973; 2: 1716. Diamond H., Alexander S., Kuzell W., Lussier A., Odone D., Tompkins R. A multi-center double-blind crossover comparison study of naproxen and aspirin in patients with rheumatoid arthritis. Scand.J. Rheumatol., Suppl. 1973; 2: 171
  • Dick W. C., Collins K. E., Buchanan W. W. Clinical studies on inflammation in small diarthrodial joints. Technetium (*mTc) percentage uptakes in various arthritides and studies on the effect of aspirin in rheumatoid arthritis. Clin. Sci. 1972; 42: 3837. Dick W. C., Collins K. E., Buchanan W. W. Clinical studies on inflammation in small diarthrodial joints. Technetium (*mTc) percentage uptakes in various arthritides and studies on the effect of aspirin in rheumatoid arthritis. Clin. Sci. 1972; 42: 383
  • Dick W. C., Deodhar S. D., Provan C. J., Nuki G., Buchanan W. W. Isotope studies in normal and diseased knee joints: 98mTc uptake related to clinical assessment and to synovial perfusion measured by the (133Xe) clearance technique. Clin. Sci. 1971; 40: 3278. Dick W. C., Deodhar S. D., Provan C. J., Nuki G., Buchanan W. W. Isotope studies in normal and diseased knee joints: 98mTc uptake related to clinical assessment and to synovial perfusion measured by the (133Xe) clearance technique. Clin. Sci. 1971; 40: 327
  • Dick W. C., Grayson M. F., Woodburn A., Nuki G., Buchanan W. W. Indices of inflammatory activity. Relationship between isotope studies and clinical methods. Ann. rheum. Dis. 1970; 29: 6439. Dick W. C., Grayson M. F., Woodburn A., Nuki G., Buchanan W. W. Indices of inflammatory activity. Relationship between isotope studies and clinical methods. Ann. rheum. Dis. 1970; 29: 643
  • Dick W. C., Neufeld R. R., Prentice A. G., Woodburn A., Whaley K., Nuki G., Buchanan W. W. Measurement of joint inflammation: a radioisotope method. Ann. rheum. Dis. 1970; 29: 13510. Dick W. C., Neufeld R. R., Prentice A. G., Woodburn A., Whaley K., Nuki G., Buchanan W. W. Measurement of joint inflammation: a radioisotope method. Ann. rheum. Dis. 1970; 29: 135
  • D'Omezon Y. Etude des cliniciens francais sur Taction de naproxene dans la P.C.E. Scand. J. Rheumatol. 1973; 2: 164, Suppl.11. D'Omezon Y. Etude des cliniciens francais sur Taction de naproxene dans la P.C.E. Scand. J. Rheumatol. 1973; 2: 164, Suppl.
  • Ellis D. J., Martin B. The plasma protein binding properties of a new nonsteroidal anti-inflammatory agent. Fed. Proc 1971; 30: 120012. Ellis D. J., Martin B. The plasma protein binding properties of a new nonsteroidal anti-inflammatory agent. Fed. Proc 1971; 30: 1200
  • Fried J. H., Harrison I. T., Lewis B., Riegl J., Rooks W., Tomolonis A. Structure activity relationship among 6-substituted-2-naphthylacetic acids. Scand. J. Rheumatol. 1973; 2: 7, Suppl.13. Fried J. H., Harrison I. T., Lewis B., Riegl J., Rooks W., Tomolonis A. Structure activity relationship among 6-substituted-2-naphthylacetic acids. Scand. J. Rheumatol. 1973; 2: 7, Suppl.
  • Hallesy D. W., Shott L. D., Hill R. Comparative toxicology of naproxen. Scand. J. Rheumatol. 1973; 2: 20, Suppl.14. Hallesy D. W., Shott L. D., Hill R. Comparative toxicology of naproxen. Scand. J. Rheumatol. 1973; 2: 20, Suppl.
  • Halvorsen L., Dotevall G., Sevelius H. Comparative effects of aspirin and naproxen on gastric mucosa. Scand. J. Rheumatol. 1973; 2: 43, Suppl.15. Halvorsen L., Dotevall G., Sevelius H. Comparative effects of aspirin and naproxen on gastric mucosa. Scand. J. Rheumatol. 1973; 2: 43, Suppl.
  • Harrison I. T., Lewis B., Nelson P., Rooks W., Roszkowski A., Tomolonis A., Fried J. H. Non-steroidal anti-inflammatory agents. I. 6-substituted 2-naphthylacetic acids. J. med. Chem. 1970; 13: 20316. Harrison I. T., Lewis B., Nelson P., Rooks W., Roszkowski A., Tomolonis A., Fried J. H. Non-steroidal anti-inflammatory agents. I. 6-substituted 2-naphthylacetic acids. J. med. Chem. 1970; 13: 203
  • Hart F. D. Naproxen (Naprosyn) and gastro-intestinal haemorrhage. Brit. med. J. 1974; 2: 5117. Hart F. D. Naproxen (Naprosyn) and gastro-intestinal haemorrhage. Brit. med. J. 1974; 2: 51
  • Helby-Petersen P., Ibfelt H., Rossel I. A double-blind crossover comparison of naproxen and placebo in rheumatoid arthritis. Scand. J. Rheumatol. 1973; 2: 145, Suppl.18. Helby-Petersen P., Ibfelt H., Rossel I. A double-blind crossover comparison of naproxen and placebo in rheumatoid arthritis. Scand. J. Rheumatol. 1973; 2: 145, Suppl.
  • Hill H. F. H., Hill A. G. S., Mowat A. G., Ansell B. M., Mathews J. A., Seifert M. H., Gumpel J. M., Christie G. A. Multi-centre double-blind crossover trial comparing naproxen and aspirin in rheumatoid arthritis. Scand. J. Rheumatol. 1973; 2: 176, Suppl.19. Hill H. F. H., Hill A. G. S., Mowat A. G., Ansell B. M., Mathews J. A., Seifert M. H., Gumpel J. M., Christie G. A. Multi-centre double-blind crossover trial comparing naproxen and aspirin in rheumatoid arthritis. Scand. J. Rheumatol. 1973; 2: 176, Suppl.
  • Hill H. F. H., Hill A. G. S., Mowat A. G., Ansell B. M., Mathews J. A., Seifert M. H., Gumpel J. M., Christie G. A. Naproxen. A new non-hormonal anti-inflammatory agent. Studies in rheumatoid arthritis. Ann. rheum. Dis. 1974; 33: 1220. Hill H. F. H., Hill A. G. S., Mowat A. G., Ansell B. M., Mathews J. A., Seifert M. H., Gumpel J. M., Christie G. A. Naproxen. A new non-hormonal anti-inflammatory agent. Studies in rheumatoid arthritis. Ann. rheum. Dis. 1974; 33: 12
  • Jasani M. K., Downie W. W., Samuels B. M., Buchanan W. W. Ibuprofen in rheumatoid arthritis. Clinical study of analgesic and anti-inflammatory activity. Ann. rheum. Dis. 1968; 27: 45721. Jasani M. K., Downie W. W., Samuels B. M., Buchanan W. W. Ibuprofen in rheumatoid arthritis. Clinical study of analgesic and anti-inflammatory activity. Ann. rheum. Dis. 1968; 27: 457
  • Katona G. Four years of clinical experience with naproxen and objective methods of evaluation. Scand. J. Rheumatol. 1973; 2: 101, Suppl.22. Katona G. Four years of clinical experience with naproxen and objective methods of evaluation. Scand. J. Rheumatol. 1973; 2: 101, Suppl.
  • Kogstad D. A double-blind crossover study of naproxen and indomethacin in patients with rheumatoid arthritis. Scand. J. Rheumatol. 1973; 2: 159, Suppl.23. Kogstad D. A double-blind crossover study of naproxen and indomethacin in patients with rheumatoid arthritis. Scand. J. Rheumatol. 1973; 2: 159, Suppl.
  • Lee P., Baxter A., Dick W. C., Webb J. An assessment of grip strength measurements in rheumatoid arthritis. Scand. J. Rheumatol. 1974; 3: 1724. Lee P., Baxter A., Dick W. C., Webb J. An assessment of grip strength measurements in rheumatoid arthritis. Scand. J. Rheumatol. 1974; 3: 17
  • Lussier A., Myhal D., Boost G., Varady J., Segre E., Strauss W. Long-term study of naproxen challenged by a short-term double-blind crossover study with placebo in rheumatoid arthritis. Scand. J. Rheumatol. 1973; 2: 113, Suppl.25. Lussier A., Myhal D., Boost G., Varady J., Segre E., Strauss W. Long-term study of naproxen challenged by a short-term double-blind crossover study with placebo in rheumatoid arthritis. Scand. J. Rheumatol. 1973; 2: 113, Suppl.
  • Reynolds P. M. G., Whorwell P. J. A single-blind crossover comparison of fenoprofen, ibuprofen and naproxen in rheumatoid arthritis. Curr. med. Res. Opin. 1974; 2: 46126. Reynolds P. M. G., Whorwell P. J. A single-blind crossover comparison of fenoprofen, ibuprofen and naproxen in rheumatoid arthritis. Curr. med. Res. Opin. 1974; 2: 461
  • Ritchie D. M., Boyle J. A., Mclnnes J. M., Jasani M. K., Dalakos T. G., Grieveson P., Buchanan W. W. Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Quart. J. Med. (N.S.) 1968; 37: 39327. Ritchie D. M., Boyle J. A., Mclnnes J. M., Jasani M. K., Dalakos T. G., Grieveson P., Buchanan W. W. Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Quart. J. Med. (N.S.) 1968; 37: 393
  • Rooks W. H. The activity of D-2-(6′-methoxy-2′-naphthyl) propionic acid (naproxen) versus adjuvant-induced arthritis. Fed. Proc 1971; 30, Abstr. 38628. Rooks W. H. The activity of D-2-(6′-methoxy-2′-naphthyl) propionic acid (naproxen) versus adjuvant-induced arthritis. Fed. Proc 1971; 30, Abstr. 386
  • Ropes M. W., Bennett G. A., Cobb S., Jacox R., Jessar R. A. Diagnostic criteria for rheumatoid arthritis. 1958 Revision. Bull, rheum. Dis. 1959; 9: 17529. Ropes M. W., Bennett G. A., Cobb S., Jacox R., Jessar R. A. Diagnostic criteria for rheumatoid arthritis. 1958 Revision. Bull, rheum. Dis. 1959; 9: 175
  • Roszkowski A. P., Rooks W., Tomolonis A., Miller L. M., Pelezarska A. B. Pharmacological properties of naproxen. Scand. J. Rheumatol. 1973; 2: 12, Suppl.30. Roszkowski A. P., Rooks W., Tomolonis A., Miller L. M., Pelezarska A. B. Pharmacological properties of naproxen. Scand. J. Rheumatol. 1973; 2: 12, Suppl.
  • Roth S. H. Safety and efficacy of Naprosyn therapy in rheumatoid arthritis patients with upper gastro-intestinal dysfunction. Naprosyn in the treatment of Rheumatic Diseases. Proceedings of a Symposium held in London, October 1973, 1973; 50, Syntex31. Roth S. H. Safety and efficacy of Naprosyn therapy in rheumatoid arthritis patients with upper gastro-intestinal dysfunction. Naprosyn in the treatment of Rheumatic Diseases. Proceedings of a Symposium held in London, October 1973, 1973; 50, Syntex
  • Runkel R., Chaplin M., Boost G., Segre E., Forchielli E. Absorption, distribution, metabolism and excretion of naproxen in various laboratory animals and human subjects. J. pharm. Sci. 1972; 61: 70332. Runkel R., Chaplin M., Boost G., Segre E., Forchielli E. Absorption, distribution, metabolism and excretion of naproxen in various laboratory animals and human subjects. J. pharm. Sci. 1972; 61: 703
  • Runkel R., Forchielli E., Sevelius H., Chaplin M., Segre E. Nonlinear plasma level response to high doses of naproxen. Clin. Pharmacol. Ther. 1974; 15: 26133. Runkel R., Forchielli E., Sevelius H., Chaplin M., Segre E. Nonlinear plasma level response to high doses of naproxen. Clin. Pharmacol. Ther. 1974; 15: 261
  • Runkel R. A., Kraft K. S., Boost G., Sevelius H., Forchielli E., Hill R., Magoun R., Szakacs J. B., Segre E. Naproxen oral absorption characteristics. Chem. pharm. Bull. 1972; 20: 145734. Runkel R. A., Kraft K. S., Boost G., Sevelius H., Forchielli E., Hill R., Magoun R., Szakacs J. B., Segre E. Naproxen oral absorption characteristics. Chem. pharm. Bull. 1972; 20: 1457
  • Segre E. J. Naprosyn metabolism in man. Naprosyn in the treatment of Rheumatic Diseases. Proceedings of a Symposium held in London, October 1973, 1973; 11, Syntex35. Segre E. J. Naprosyn metabolism in man. Naprosyn in the treatment of Rheumatic Diseases. Proceedings of a Symposium held in London, October 1973, 1973; 11, Syntex
  • Segre E. J. Efficacy of Naprosyn in rheumatoid arthritis - placebo comparisons. Naprosyn in the treatment of Rheumatic Diseases. Proceedings of a Symposium held in London, October 1973, 1973; 17, Syntex36. Segre E. J. Efficacy of Naprosyn in rheumatoid arthritis - placebo comparisons. Naprosyn in the treatment of Rheumatic Diseases. Proceedings of a Symposium held in London, October 1973, 1973; 17, Syntex
  • Segre E., Sevelius H., Chaplin M., Forchielli E., Runkel R., Rooks W. Interaction of naproxen and aspirin in the rat and in man. Scand. J. Rheumatol. 1973; 2: 37, Suppl.37. Segre E., Sevelius H., Chaplin M., Forchielli E., Runkel R., Rooks W. Interaction of naproxen and aspirin in the rat and in man. Scand. J. Rheumatol. 1973; 2: 37, Suppl.
  • Steinbrocker O., Traeger C. H., Batterman R. C. Therapeutic criteria in rheumatoid arthritis. J. Amer. med. Ass. 1949; 140: 65938. Steinbrocker O., Traeger C. H., Batterman R. C. Therapeutic criteria in rheumatoid arthritis. J. Amer. med. Ass. 1949; 140: 659
  • Tomlinson R. V., Ringold H. J., Qureshi M. C., Forchielli E. Relationship between inhibition of prostaglandin synthesis and drug efficacy: support for the current theory on mode of action of aspirin-like drugs. Biochem. biophys. Res. Commun. 1972; 46: 55239. Tomlinson R. V., Ringold H. J., Qureshi M. C., Forchielli E. Relationship between inhibition of prostaglandin synthesis and drug efficacy: support for the current theory on mode of action of aspirin-like drugs. Biochem. biophys. Res. Commun. 1972; 46: 552
  • Webb J., Downie W. W., Dick W. C., Lee P. Evaluation of digital joint circumference measurements in rheumatoid arthritis. Scand. J. Rheumatol. 1973; 2: 12740. Webb J., Downie W. W., Dick W. C., Lee P. Evaluation of digital joint circumference measurements in rheumatoid arthritis. Scand. J. Rheumatol. 1973; 2: 127
  • Willkens R. F. Double-blind crossover trial of naproxen and placebo in patients with rheumatoid arthritis. Scand. J. Rheumatol. 1973; 2: 132, Suppl.41. Willkens R. F. Double-blind crossover trial of naproxen and placebo in patients with rheumatoid arthritis. Scand. J. Rheumatol. 1973; 2: 132, Suppl.

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