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Journal of the International Society of Sports Nutrition Volume 10, 2013 - Issue 1

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Research Article

Effects of betaine on body composition, performance, and homocysteine thiolactone

Jason M Cholewa1 Department of KinesiologyRecreation, and Sport Studies, Coastal Carolina UniversityConwaySCUSACorrespondence[email protected]

Monika Wyszczelska-Rokiel2 Department of Environmental ChemistryUniversity of LodzPomorska 16390-236LodzPoland, USA

Rafal Glowacki2 Department of Environmental ChemistryUniversity of LodzPomorska 16390-236LodzPoland, USA

Hieronim Jakubowski3 Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Department of Biochemistry and BiotechnologyLife Sciences UniversityPoznanNJPoland;4 UNDMJ-New Jersey Medical SchoolNewarkNJUSA

Tracey Matthews5 Department of Exercise Science and Sport StudiesSpringfield CollegeSpringfieldMAUSA

Richard Wood5 Department of Exercise Science and Sport StudiesSpringfield CollegeSpringfieldMAUSA

Stuart AS Craig6 DuPont Nutrition & HealthTarrytownNYUSA

Vincent Paolone5 Department of Exercise Science and Sport StudiesSpringfield CollegeSpringfieldMAUSA

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Article: 39 | Published online: 01 Apr 2022

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https://doi.org/10.1186/1550-2783-10-39

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CraigSAS Betaine in human nutrition Am J Clin Nutr 2004 80 539 549 1:CAS:528:DC%2BD2cXnsVWitbc%3D 15321791
PubMed Web of Science ®Google Scholar
LeeEC MareshCM KraemerWJ YamamotoLM HatfieldDL BaileyBL ArmstrongLE VolekJS McDermottBP CraigSA Ergogenic effects of betaine supplementation on strength and power performance J Int Soc Sports Nutr 2010 7 27 2915951 https://doi.org/10.1186/1550-2783-7-27 20642826
PubMed Web of Science ®Google Scholar
HoffmanJR RatamessNA KangJ RashtiSL FaigenbaumAD Effect of betaine supplementation on power performance and fatigue J Int Soc Sports Nutr 2009 6 7 2651845 https://doi.org/10.1186/1550-2783-6-7 19250531
PubMed Web of Science ®Google Scholar
TrepanowskiJF FarneyTM McCarthyCG SchillingBK CraigSA BloomerRJ The effects of chronic betaine supplementation on exercise performance, skeletal muscle oxygen saturation and associated biochemical parameters in resistance trained men J Strength Cond Res 2011 25 3461 3471 https://doi.org/10.1519/JSC.0b013e318217d48d 22080324
PubMed Web of Science ®Google Scholar
Del FaveroS RoschelH ArtioliG UgrinowitschC TricoliV CostaA BarrosoR NegrelliAL OtaduyMC da Costa LeiteC Lancha-JuniorAH GualanoB Creatine but not betaine supplementation increases muscle phosphorylcreatine content and strength performance Amino Acids 2011
Google Scholar
SchwabU TörrönenA ToppinenL AlfthanG SaarinenM AroA UusitupaM Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects Am J Clin Nutr 2002 76 961 967 1:CAS:528:DC%2BD38XosF2qsr0%3D 12399266
PubMed Web of Science ®Google Scholar
HuangQC XuZR HanXY LiWF Effect of betaine on growth hormone pulsatile secretion and serum metabolites in finishing pigs J Anim Physiol Anim Nutr 2007 91 85 90 1:CAS:528:DC%2BD2sXksFWqs78%3D https://doi.org/10.1111/j.1439-0396.2006.00644.x
PubMed Web of Science ®Google Scholar
HuangQ XuZ HanX LiW Effect of dietary betaine supplementation on lipogenic enzyme activities and fatty acid synthase mRNA expression in finishing pigs Anim Feed Sci Technol 2008 140 365 375 1:CAS:528:DC%2BD1cXlvV2ltg%3D%3D https://doi.org/10.1016/j.anifeedsci.2007.03.007
Web of Science ®Google Scholar
MatthewsJO SouthernLL HigbieAD PersicaMA BidnerTD Effects of betaine on growth, carcass characteristics, pork quality, and plasma metabolites of finishing pigs J Anim Sci 2001 79 722 728 1:CAS:528:DC%2BD3MXjsVygtbs%3D 11263833
PubMed Web of Science ®Google Scholar
GarciaMM Guéant-RodriguezR-M PooyaS BrachetP AlbertoJ-M JeannessonE MaskaliF GueguenN MarieP-Y LacolleyP HerrmannM JuillièreY MalthieryY GuéantJ-L Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC-1α by PRMT1 and SIRT1 J Pathol 2011 225 324 335 1:CAS:528:DC%2BC3MXht1yhtLjE https://doi.org/10.1002/path.2881 21633959
PubMed Web of Science ®Google Scholar
LiY JiangC XuG WangN ZhuY TangC WangX Homocysteine upregulates resistin production from adipocytes in vivo and in vitro Diabetes 2008 57 817 827 1:CAS:528:DC%2BD1cXksVGktb4%3D https://doi.org/10.2337/db07-0617 18192543
PubMed Web of Science ®Google Scholar
ChwatkoG BoersGHJ StraussKA ShihDM JakubowskiH Mutations in methylenetetrahydrofolate reductase or cystathionine beta-synthase gene, or a high-methionine diet, increase homocysteine thiolactone levels in humans and mice Journal Fed Am Soc Exp Biol 2007 21 1707 1713 1:CAS:528:DC%2BD2sXmsVWlu7g%3D 17327360
PubMed Web of Science ®Google Scholar
NajibS Sánchez-MargaletV Homocysteine thiolactone inhibits insulin-stimulated DNA and protein synthesis: possible role of mitogen-activated protein kinase (MAPK), glycogen synthase kinase-3 (GSK-3) and p70 S6K phosphorylation J Mol Endocrinol 2005 34 119 126 1:CAS:528:DC%2BD2MXhs1KmtL0%3D https://doi.org/10.1677/jme.1.01581 15691882
PubMed Web of Science ®Google Scholar
JakubowskiH Pathophysiological consequences of homocysteine excess J Nutr 2006 136 1741 1749
PubMed Web of Science ®Google Scholar
WilliamsKT SchalinskeKL New insights into the regulation of methyl group and homocysteine metabolism J Nutr 2007 137 311 314 1:CAS:528:DC%2BD2sXhsVWjtb4%3D 17237303
PubMed Web of Science ®Google Scholar
KleinerSM BazzarreTL LitchfordMD Metabolic profiles, diet, and health practices of championship male and female bodybuilders J Am Diet Assoc 1990 90 962 967 1:STN:280:DyaK3czgvVWltQ%3D%3D 2365938
PubMed Web of Science ®Google Scholar
Ritti-DiasRM AvelarA SalvadorEP CyrinoES Influence of previous experience on resistance training on reliability of one-repetition maximum test J Strength Cond Res 2011 25 1418 1422 https://doi.org/10.1519/JSC.0b013e3181d67c4b 21522076
PubMed Web of Science ®Google Scholar
ForsythHL SinningWE The anthropometric estimation of body density and lean body weight of male athletes Med Sci Sports Exerc 1973 5 174 180 1:STN:280:DyaE2c%2Fhs1aisQ%3D%3D https://doi.org/10.1249/00005768-197323000-00015
Web of Science ®Google Scholar
BrozekJ GrandeF AndersonJT KeysA Densitometric analysis of body composition: revision of some quantitative assumptions Ann NY Acad Sci 1963 110 113 140 1:CAS:528:DyaF2cXjt1Onsw%3D%3D https://doi.org/10.1111/j.1749-6632.1963.tb17079.x 14062375
PubMed Web of Science ®Google Scholar
DeFreitasJM BeckTW StockMS DillonMA KasishkePR An examination of the time course of training-induced skeletal muscle hypertrophy Eur J Appl Physiol 2011 111 2785 2790 https://doi.org/10.1007/s00421-011-1905-4 21409401
PubMedGoogle Scholar
MoritaniT DeVriesHA Neural factors versus hypertrophy in the time course of muscle strength gain Am J Phys Med 1979 58 115 130 1:STN:280:DyaE1M3gs12htQ%3D%3D 453338
PubMedGoogle Scholar
DeFreitasJM BeckTW StockMS DillonMA SherkVD StoutJR CramerJT A comparison of techniques for estimating training-induced changes in muscle cross-sectional area J Strength Cond Res 2010 24 2383 2389 https://doi.org/10.1519/JSC.0b013e3181ec86f3 20802282
PubMedGoogle Scholar
LanderJ Maximum based on reps J Strength Cond Res 1985 6 60 61
Google Scholar
ChwatkoG JakubowskiH The determination of homocysteine-thiolactone in human plasma Anal Biochem 2005 337 271 277 1:CAS:528:DC%2BD2MXhtVKiu7Y%3D https://doi.org/10.1016/j.ab.2004.11.035 15691507
PubMed Web of Science ®Google Scholar
GłowackiR BaldE JakubowskiH An on-column derivatization method for the determination of homocysteine-thiolactone and protein N-linked homocysteine Amino Acids 2011 41 187 194 https://doi.org/10.1007/s00726-010-0521-7 20204437
PubMedGoogle Scholar
JakubowskiH The determination of homocysteine-thiolactone in biological samples Anal Biochem 2002 308 112 119 1:CAS:528:DC%2BD38XmvFSitLg%3D https://doi.org/10.1016/S0003-2697(02)00224-5 12234471
PubMed Web of Science ®Google Scholar
MonteiroAG AokiMS EvangelistaAL AlvenoDA MonteiroGA Piçarro I daC UgrinowitschC Nonlinear periodization maximizes strength gains in split resistance training routines J Strength Cond Res 2009 23 1321 1326 https://doi.org/10.1519/JSC.0b013e3181a00f96 19528843
PubMed Web of Science ®Google Scholar
SpinetiJ de SallesBF RheaMR LavigneD MattaT MirandaF FernandesL SimãoR Influence of exercise order on maximum strength and muscle volume in nonlinear periodized resistance training J Strength Cond Res 2010 24 2962 2969 https://doi.org/10.1519/JSC.0b013e3181e2e19b 20938358
PubMed Web of Science ®Google Scholar
SchoenfeldBJ The mechanisms of muscle hypertrophy and their application to resistance training J Strength Cond Res 2010 24 2857 2872 https://doi.org/10.1519/JSC.0b013e3181e840f3 20847704
PubMed Web of Science ®Google Scholar
HäussingerD The role of cellular hydration in the regulation of cell function Biochem J 1996 313 3 697 710 1216967 https://doi.org/10.1042/bj3130697 8611144
PubMedGoogle Scholar
Ortiz-CostaS SorensonMM Sola-PennaM Betaine protects urea-induced denaturation of myosin subfragment-1 FEBS J 2008 275 3388 3396 1:CAS:528:DC%2BD1cXot1Ogurc%3D https://doi.org/10.1111/j.1742-4658.2008.06487.x 18494798
PubMedGoogle Scholar
SuarezMC MachadoCJV LimaLMTR SmillieLB PearlstoneJR SilvaJL SorensonMM FoguelD Role of hydration in the closed-to-open transition involved in Ca2+ binding by troponin C Biochemistry 2003 42 5522 5530 1:CAS:528:DC%2BD3sXivFOqu7o%3D https://doi.org/10.1021/bi027102h 12731895
PubMed Web of Science ®Google Scholar
AbeT DeHoyosDV PollockML GarzarellaL Time course for strength and muscle thickness changes following upper and lower body resistance training in men and women Eur J Appl Physiol 2000 81 174 180 1:STN:280:DC%2BD3c7gtlOhuw%3D%3D https://doi.org/10.1007/s004210050027 10638374
PubMed Web of Science ®Google Scholar
HoffmanJR RatamessNA KangJ GonzalezAM BellerNA CraigSAS Effect of 15 days of betaine ingestion on concentric and eccentric force outputs during isokinetic exercise J Strength Cond Res 2011 25 2235 2241 https://doi.org/10.1519/JSC.0b013e3182162530 21747291
PubMed Web of Science ®Google Scholar
NewtonRU KraemerWJ Developing explosive muscular power: implications for a mixed methods training strategy J Strength Cond Res 1994 16 20 31 https://doi.org/10.1519/1073-6840(1994)016<0020:DEMPIF>2.3.CO;2
Google Scholar
VerhoefP Homocysteine–an indicator of a healthy diet? Am J Clin Nutr 2007 85 1446 1447 1:CAS:528:DC%2BD2sXmvVWqt7Y%3D 17556678
PubMed Web of Science ®Google Scholar
OlthofMR VerhoefP Effects of betaine intake on plasma homocysteine concentrations and consequences for health Curr Drug Metab 2005 6 15 22 1:CAS:528:DC%2BD2MXhsVCqtL4%3D https://doi.org/10.2174/1389200052997366 15720203
PubMed Web of Science ®Google Scholar
ApicellaJM LeeEC BaileyBL SaenzC AndersonJM CraigSAS KraemerWJ VolekJS MareshCM Betaine supplementation enhances anabolic endocrine and Akt signaling in response to acute bouts of exercise Eur J Appl Physiol 2012 In Press
Google Scholar
JakubowskiH The pathophysiological hypothesis of homocysteine thiolactone-mediated vascular disease J Physiol Pharmacol 2008 59 Suppl 9 155 167 19261978
PubMed Web of Science ®Google Scholar
KathirvelE MorganK NandgiriG SandovalBC CaudillMA BottiglieriT FrenchSW MorganTR Betaine improves nonalcoholic fatty liver and associated hepatic insulin resistance: a potential mechanism for hepatoprotection by betaine Am J Gastrointestinal Liver Physiol 2010 299 1068 1077 https://doi.org/10.1152/ajpgi.00249.2010
PubMed Web of Science ®Google Scholar
BarathiS AngayarkanniN PasupathiA NatarajanSK PukrajR DhupperM VelpandianT MuralidharanC SivashanmughamM Homocysteinethiolactone and paraoxonase: novel markers of diabetic retinopathy Diabetes care 2010 33 2031 2037 2928358 1:CAS:528:DC%2BC3cXht1OmurnE https://doi.org/10.2337/dc10-0132 20551012
PubMed Web of Science ®Google Scholar
BorowczykK ShihDM JakubowskiH Metabolism and neurotoxicity of homocysteine thiolactone in mice: evidence for a protective role of paraoxonase 1 J Alzheimers Dis 2012 30 225 231 3544478 1:CAS:528:DC%2BC38Xnt1Cis7w%3D 22406444
PubMed Web of Science ®Google Scholar

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