Search in:

Journal of the International Society of Sports Nutrition Volume 4, 2007 - Issue 1

Submit an article Journal homepage

Open access

235

Views

CrossRef citations to date

Altmetric

Research Article

Effects of eight weeks of an alleged aromatase inhibiting nutritional supplement 6-OXO (androst-4-ene-3,6,17-trione) on serum hormone profiles and clinical safety markers in resistance-trained, eugonadal males

Dan Rohle1 Pharmacology DepartmentWeill Cornell Graduate School of Medical Sciences445 East 69th Street, Room 41210021New YorkNYUSA

Colin Wilborn2 Department of Exercise and Sport ScienceUniversity of Mary Hardin-Baylor, UMHB Station900 College Box 801076513BeltonTexasUSA

Lem Taylor3 Department of Health, Leisure, and Exercise ScienceUniversity of West Florida11000# 72-219, Pensacola32514University ParkwayFLUSA

Chris Mulligan4 Department of Nutrition and Food ScienceColorado State University80523Fort CollinsCOUSA

Richard Kreider5 Department of HealthHuman Performance, and Recreation, Baylor UniversityBox 9731376798WacoTXUSA

Darryn Willoughby5 Department of HealthHuman Performance, and Recreation, Baylor UniversityBox 9731376798WacoTXUSA;6 Institute for Biomedical StudiesBaylor University76798WacoTXUSACorrespondence[email protected]

Article: 13 | Published online: 06 May 2022

Cite this article
https://doi.org/10.1186/1550-2783-4-13

Full Article
Figures & data
References
Citations
Metrics
Licensing
Reprints & Permissions
View PDF PDF

References

BhasinSStorerTBermanNYarasheskiKClevengerBPhillipsJLeeWBunnellTCasaburiRTestosterone replacement increases fat-free mass and muscle size in hypogonadal menJ Clin Endocrinol Metab199782407131:CAS:528:DyaK2sXhtVamtrg%3D9024227
PubMed Web of Science ®Google Scholar
BhasinSStorerTJavanbakhtMBermanNYarasheskiKPhillipsJDikeMSinha-HikimIShenRHaysRBeallGTestosterone replacement and resistance exercise in HIV-infected men with weight loss and low testosterone levelsJAMA20002837637031730371:CAS:528:DC%2BD3cXht1KmtL0%3Dhttps://doi.org/10.1001/jama.283.6.76310683055
PubMed Web of Science ®Google Scholar
BhasinSWoodhouseLCasaburiRSinghABhasinDBerman ChenXYarasheskiKMaglianoLDzekovCDzekovJBrossRPhillipsJSinha-HikimIShenRStorerTTestosterone dose-response relationships in healthy young menAm J Physiol Endocrinol Metab2001281E1172811:CAS:528:DC%2BD3MXptlKmsbc%3D11701431
PubMed Web of Science ®Google Scholar
BhasinSWoodhouseLStorerTProof of the effect of testosterone on skeletal muscleJ Endocrinol200117027381:CAS:528:DC%2BD3MXltlalu7s%3Dhttps://doi.org/10.1677/joe.0.170002711431134
PubMed Web of Science ®Google Scholar
Sinha-HikimIArtazaJWoodhouseLGonzalez-CadavidNSinghALeeMStorerTCasaburiRShenRBhasinSTestosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophyAm J Physiol Endocrinol Metab20022831E154E1641:CAS:528:DC%2BD38XlsVCrtrk%3Dhttps://doi.org/10.1152/ajpendo.00502.200112067856
PubMed Web of Science ®Google Scholar
Sinha-HikimIRothSLeeMBhasinSTestosterone-induced muscle hypertrophy is associated with an increase in satellite cell number in healthy, young menAm J Physiol Endocrinol Metab2003285E197E2051:CAS:528:DC%2BD3sXls1Wnu7Y%3Dhttps://doi.org/10.1152/ajpendo.00370.200212670837
PubMed Web of Science ®Google Scholar
SchroederETerkMSattlerFAndrogen therapy improves muscle mass and strength but not muscle quality: results from two studiesAm J Physiol Endocrinol Metab2003285E16241:CAS:528:DC%2BD3sXls1WntbY%3Dhttps://doi.org/10.1152/ajpendo.00032.200312637255
PubMed Web of Science ®Google Scholar
BrownGMartiniERobertsSVukovichMKingDAcute hormonal response to sublingual androstenediol intake in young menJ Appl Physiol200292142461:CAS:528:DC%2BD38XnvFersQ%3D%3Dhttps://doi.org/10.1152/japplphysiol.00477.200111744653
PubMed Web of Science ®Google Scholar
BrownGMcKenzieDAcute resistance exercise does not change the hormonal response to sublingual androstenediol intakeEur J Appl Physiol200697404121:CAS:528:DC%2BD28Xmtlaju7Y%3Dhttps://doi.org/10.1007/s00421-006-0194-916636857
PubMedGoogle Scholar
BroederCQuindryJBrittinghamKPantonLThomsonJAppakonduSet alPhysiological and hormonal influences on androstenedione supplementation in men 35 to 65 years old participating in a high-intensity resistance training programArch Intern Med200016030931041:STN:280:DC%2BD3M%2FmvVCrtA%3D%3Dhttps://doi.org/10.1001/archinte.160.20.309311074738
PubMed Web of Science ®Google Scholar
KingDSharpRVukovichMBrownGReifenrathTUhlNParsonsKEffect of oral androstenedione on serum testosterone and adaptations to resistance training in young menJAMA19992812020281:CAS:528:DyaK1MXjvFOls7k%3Dhttps://doi.org/10.1001/jama.281.21.202010359391
PubMed Web of Science ®Google Scholar
BeckhamSEarnestCFour weeks of androstenedione supplementation diminishes the treatment response in middle aged menBr J Sports Med2003372121817246461:STN:280:DC%2BD3s3ls1agug%3D%3Dhttps://doi.org/10.1136/bjsm.37.3.21212782545
PubMedGoogle Scholar
MaurasNO'BrienKKleinKHayesVEstrogen suppression in males: metabolic effectsJ Clin Endocrinol Metab2000852370771:CAS:528:DC%2BD3cXlt1Wntr8%3D10902781
PubMed Web of Science ®Google Scholar
MaurasNLimaJPatelDRiniAdiSalleEKwokALippeBPharmacokinetics and dose finding of a potent aromatase inhibitor, aromasin (exemestane), in young malesJ Clin Endocrinol Metab2003885951561:CAS:528:DC%2BD3sXhtVSgsrvKhttps://doi.org/10.1210/jc.2003-03127914671195
PubMed Web of Science ®Google Scholar
TaxelPKennedyDFallPWillardACliveJRaiszLThe effect of aromatase inhibition on sex steroids, gonadotropins, and markers of bone turnover in older menJ Clin Endocrinol Metab2001862869741:CAS:528:DC%2BD3MXktlKhs7g%3D11397902
PubMed Web of Science ®Google Scholar
WilloughbyDWilbornCTaylorLCampbellBEight weeks of aromatase inhibition using the nutritional supplement Novedex XT: Effects on steroid hormones, body composition, and clinical safety markers in young, eugonadal menInt J Sport Nutr Exerc Metab2007171921081:CAS:528:DC%2BD2sXjsFeksL4%3D17460335
PubMedGoogle Scholar
NumazawaMTsujiMMutsumiAStudies on aromatase inhibition with 4-androstene-3,6,17-trione: its 3 beta-reduction and time-dependent irreversible binding to aromatase with human placental microsomesJ Steroid Biochem19972833744https://doi.org/10.1016/0022-4731(87)91028-4
Google Scholar
NumazawaMMutsumiATachibanaMMechanism for aromatase inactivation by a suicide substrate, androst-4-ene-3,6,17-trione. The 4 beta, 5 beta-epoxy-19-oxo derivative as a reactive electrophile irreversibly binding to the active siteBiochem Pharmacol1996521253591:CAS:528:DyaK28Xms1Snurw%3Dhttps://doi.org/10.1016/0006-2952(96)00479-08937433
PubMedGoogle Scholar
LederBRohrerJRubinSGalloJLongcopeCEffects of aromatase inhibition in elderly men with low or borderline-low serum testosterone levelsJ Clin Endocrinol Metab2004891174801:CAS:528:DC%2BD2cXisVWruro%3Dhttps://doi.org/10.1210/jc.2003-03146715001605
PubMed Web of Science ®Google Scholar
O'ConnorKStipEPélissierMAardemaFGuaySGuadetteMVan HaasterIRobillardSGrenierSCareauYDoucetPLeblancVTreating delusional disorder: a comparison of cognitive-behavioural therapy and attention placebo controlCan J Psychiatry200752318219017479527
PubMed Web of Science ®Google Scholar
HossianAHornickCAndrogenic modulation of lipid metabolism at subcellular sties in cholestatic ratsHorm Metab Res1994261925https://doi.org/10.1055/s-2007-1000766
Google Scholar
MaurasNRiniAWelchSSagerBMurphySPSynergistic effects of testosterone and growth hormone on protein metabolism and body composition in prepubertal boysMetabolism20035289649691:CAS:528:DC%2BD3sXlvVGqu7w%3Dhttps://doi.org/10.1016/S0026-0495(03)00163-X12898459
PubMedGoogle Scholar
HardenCMacLuskyNAromatase inhibition, testosterone, and seizuresEpilepsy Behav2004526063https://doi.org/10.1016/j.yebeh.2003.12.00115123030
PubMed Web of Science ®Google Scholar
IncledonTThe chronic effects of androst-4-ene-3,6,17-trione on endocrine responses in resistance-trained menUnpublished observations2003
Google Scholar
MeinhardtUMullisPThe aromatase cytochrome P-450 and its clinical impactHorm Res200257145521:CAS:528:DC%2BD38XksVygsbw%3Dhttps://doi.org/10.1159/00005837412053085
PubMed Web of Science ®Google Scholar
HayesFSeminaraSDecruzSBoepplePCrowleyWAromatase inhibition in the human male reveals a hypothalamic site of estrogen feedbackJ Clin Endocrinob Metab2000853027351:CAS:528:DC%2BD3cXmsVKrur4%3D
PubMed Web of Science ®Google Scholar
SchnorrJBrayMVeldhuisJAromatization mediates testosterone's short-term feedback restraint of 24-hour endogenously driven and acute exogenous gonadotropin-releasing hormone-stimulated luteinizing hormone and follicle-stimulating hormone secretion in young menJ Clin Endocrinol Metab2001862600061:CAS:528:DC%2BD3MXktlKitbw%3D11397860
PubMedGoogle Scholar

Share icon
Back to Top

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.

People also read
Recommended articles
Cited by

To cite this article:

Reference style: APA Chicago Harvard

Citation copied to clipboard

Reference styles above use APA (6th edition), Chicago (16th edition) & Harvard (10th edition)

Download citation

Download a citation file in RIS format that can be imported by citation management software including EndNote, ProCite, RefWorks and Reference Manager.

Choose format: RIS BibTex RefWorks Direct Export

Choose options: Citation Citation & abstract Citation & references

Effects of eight weeks of an alleged aromatase inhibiting nutritional supplement 6-OXO (androst-4-ene-3,6,17-trione) on serum hormone profiles and clinical safety markers in resistance-trained, eugonadal males

References

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Effects of eight weeks of an alleged aromatase inhibiting nutritional supplement 6-OXO (androst-4-ene-3,6,17-trione) on serum hormone profiles and clinical safety markers in resistance-trained, eugonadal males

References

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date