Search in:

Advanced search

Journal of the International Society of Sports Nutrition Volume 7, 2010 - Issue 1

Submit an article Journal homepage

Open access

667

Views

CrossRef citations to date

Altmetric

Research Article

Examination of the efficacy of acute L-alanyl-L-glutamine ingestion during hydration stress in endurance exercise

Jay R Hoffman1 Department of Health and Exercise ScienceThe College of New Jersey08628EwingNJUSACorrespondence[email protected]

Nicholas A Ratamess1 Department of Health and Exercise ScienceThe College of New Jersey08628EwingNJUSA

Jie Kang1 Department of Health and Exercise ScienceThe College of New Jersey08628EwingNJUSA

Stephanie L Rashti1 Department of Health and Exercise ScienceThe College of New Jersey08628EwingNJUSA

Neil Kelly1 Department of Health and Exercise ScienceThe College of New Jersey08628EwingNJUSA

Adam M Gonzalez1 Department of Health and Exercise ScienceThe College of New Jersey08628EwingNJUSA

Michael Stec1 Department of Health and Exercise ScienceThe College of New Jersey08628EwingNJUSA

Steven Anderson1 Department of Health and Exercise ScienceThe College of New Jersey08628EwingNJUSA

Brooke L Bailey2 Department of KinesiologyUniversity of Connecticut06269StorrsCTUSA

Linda M Yamamoto2 Department of KinesiologyUniversity of Connecticut06269StorrsCTUSA

Lindsay L Hom2 Department of KinesiologyUniversity of Connecticut06269StorrsCTUSA

Brian R Kupchak2 Department of KinesiologyUniversity of Connecticut06269StorrsCTUSA

Avery D Faigenbaum1 Department of Health and Exercise ScienceThe College of New Jersey08628EwingNJUSA

Carl M Maresh2 Department of KinesiologyUniversity of Connecticut06269StorrsCTUSA

show all

Article: 8 | Published online: 06 May 2022

Cite this article
https://doi.org/10.1186/1550-2783-7-8

Full Article
Figures & data
References
Supplemental
Citations
Metrics
Licensing
Reprints & Permissions
View PDF PDF

References

NoseHMorimotoTOguraKDistribution of water losses among fluid compartments of tissues under thermal dehydration in the ratJpn J Physiol198333101910291:STN:280:DyaL2c7ovFantw%3D%3Dhttps://doi.org/10.2170/jjphysiol.33.10196674653
PubMedGoogle Scholar
SenayLCPivarnikJNFluid shifts during exerciseExerc Sport Sci Rev1985133353873891371
PubMedGoogle Scholar
HoffmanJRStavskyHFalkBThe effect of water restriction on anaerobic power and vertical jumping height in basketball playersInt J Sports Med1995162142181:STN:280:DyaK2Mzos1alsw%3D%3Dhttps://doi.org/10.1055/s-2007-9729947657413
PubMed Web of Science ®Google Scholar
CarterJEGisolfiCVFluid replacement during and after exercise in the heatMed Sci Sports Exerc1989215325391:STN:280:DyaK3c7htlygsA%3D%3Dhttps://doi.org/10.1249/00005768-198910000-000072607945
PubMed Web of Science ®Google Scholar
ArmstrongLECasaDJRotiMWLeeECCraigSASutherlandJWFialaKAMareshCMInfluence of betaine consumption on strenuous running and sprinting in a hot environmentJ Strength Cond Res200822851860https://doi.org/10.1519/JSC.0b013e31816a6efb18438230
PubMedGoogle Scholar
LimaAACarvalhoGHFigueiredoAAGifoniARSoaresAMSilvaEAGuerrantRLEffects of an alanyl-glutamine-based oral rehydration and nutrition therapy solution on electrolyte and water absorption in a rat model of secretory diarrhea induced by cholera toxinNutrition2002184584621:CAS:528:DC%2BD38XktFyht7g%3Dhttps://doi.org/10.1016/S0899-9007(02)00775-X12044816
PubMed Web of Science ®Google Scholar
NathSKDechelottePDarmaunDGottelandMRongierMDesjeuxJF(15N) and (14C) glutamine fluxes across rabbit ileum in experimental diarrheaAm J Physiol1992262G312G3181:CAS:528:DyaK38XhslWgsLk%3D1539662
PubMedGoogle Scholar
SilvaACSantos-NetoMSSoaresAMFontelesMCGuerrantRLLimaAAEfficacy of a glutamine-based oral rehydration solution on the electrolyte and water absorption in a rabbit model of secretory diarrhea induced by cholera toxinJ Pediatr Gastroenterol Nutr1998265135191:CAS:528:DyaK1cXivFWnu7c%3Dhttps://doi.org/10.1097/00005176-199805000-000069586761
PubMed Web of Science ®Google Scholar
van LoonFPBanikAKNathSKPatraFCWahedMADarmaunDDesjeuxJFMahalanabisDThe effect of L-glutamine on salt and water absorption: a jejuna perfusion study in cholera in humansEur J Gastroenterol Hepatol199684434481:STN:280:DyaK28zpsl2rug%3D%3D8804872
PubMed Web of Science ®Google Scholar
LiYXuBLiuFTanLLiJThe effect of glutamine-supplemented total parenteral nutrition on nutrition and intestinal absorptive function in a rat modelPediatr Surg Int2006225085131:CAS:528:DC%2BD1cXkvFertA%3D%3Dhttps://doi.org/10.1007/s00383-006-1693-916736219
PubMedGoogle Scholar
FürstPNew developments in glutamine deliveryJ Nutr2001131suppl25622568
Google Scholar
AbilésJMoreno-TorresRMoratallaGCastañoJPérez AbúdRMudarraAMuchadoMJPlanellsEPerez de la CruzAEffects of supply with glutamine on antioxidant system and lipid peroxidation in patients with parenteral nutritionNutr Hosp20082333233918604319
PubMedGoogle Scholar
DéchelottePHasselmannMCynoberLAllaouchicheBCoëffierMHecketsweilerBMerleVMazerollesMSambaDGuillouYMPetitJMansoorOColasGCohendyRBarnoudDCzernichowPBleichnerGL-alanyl-L-glutamine dipeptide-supplemented total parenteral nutrition reduces infectious complications and glucose intolerance in critically ill patients: the French controlled, randomized, double-blind, multicenter studyCrit Care Med200634598604https://doi.org/10.1097/01.CCM.0000201004.30750.D116505644
PubMed Web of Science ®Google Scholar
KumarHSAnandanRBiochemical studies on the cardioprotective effect of glutamine on tissue antioxidant defense system in isoprenaline-induced myocardial infarction in ratsJ Clin Biochem Nutr20074049551:CAS:528:DC%2BD2sXhtlSqurrOhttps://doi.org/10.3164/jcbn.40.49
PubMed Web of Science ®Google Scholar
CastellLMNewsholmeEAGlutamine and the effects of exhaustive exercise upon the immune responseCan J Physiol Pharmacol1998765245321:CAS:528:DyaK1cXnsVKlsrg%3Dhttps://doi.org/10.1139/y98-0549839078
PubMed Web of Science ®Google Scholar
FavanoASantos-SilvaPRNakanoEYPedrinelliAHernandezAJGreveJMPeptide glutamine supplementation for tolerance of intermittent exercise in soccer playersClinics20086327322664173https://doi.org/10.1590/S1807-5932200800010000618297203
PubMed Web of Science ®Google Scholar
GleesonMDosing and efficacy of glutamine supplementation in human exercise and sport trainingJ Nutr2008138suppl20452049
Google Scholar
ArmstrongLEMareshCMCastellaniJWBergeronMFKenefickRWLaGasseKERiebeDUrinary indices of hydration statusInt J sport Nutr199442652791:STN:280:DyaK2M%2FnvVyrug%3D%3D7987361
PubMed Web of Science ®Google Scholar
DillDBCostillDLCalculation of percentage changes in volume of blood, plasma and red cells in dehydrationJ Appl Physiol1974372472481:STN:280:DyaE2c3pvV2ntw%3D%3D4850854
PubMed Web of Science ®Google Scholar
KlassenPMazariegosMSolomonsNWFurstPThe pharmacokinetic responses of humans to 20 g of alanyl-glutamine dipeptide differ with the dosing protocol but not with gastric acidity or in patients with acute dengue feverJ Nutr20001301771821:CAS:528:DC%2BD3cXhtVSmtro%3D10720166
PubMed Web of Science ®Google Scholar
ZieglerTRBenfellKSmithRJYoungLSBrownEFerrari-BalivieraELoweDKWilmoreDWSafety and metabolic effects of L-glutamine administration in humansJ Parenter Enteral Nutr199014137S146S1:STN:280:DyaK3czotl2msw%3D%3Dhttps://doi.org/10.1177/0148607190014004201
Web of Science ®Google Scholar
RhoadsJMWuGGlutamine, arginine and leucine signaling in the intestineAmino Acids2009371111221:CAS:528:DC%2BD1MXltlemt7k%3Dhttps://doi.org/10.1007/s00726-008-0225-4
PubMed Web of Science ®Google Scholar
RogeroMMTirapeguiJPedrosaRGde CastroIAde Olveira PiresISChemBEffect of alanyl-glutamine supplementation on plasma and tissue glutamine concentrations in rats submitted to exhaustive exerciseNutrition2006225645711:CAS:528:DC%2BD28XjsFOgsro%3Dhttps://doi.org/10.1016/j.nut.2005.11.00216472983
PubMed Web of Science ®Google Scholar
McKennaMJBangsboJRenaudJMMuscle K+, Na+, and Cl disturbances and Na+-K+ pump inactivation: implications for fatigueJ Appl Physiol20081042882951:CAS:528:DC%2BD1cXhslOisLw%3Dhttps://doi.org/10.1152/japplphysiol.01037.200717962569
PubMed Web of Science ®Google Scholar
MourtzakisMSaltinBGrahamTPilegaardHCarbohydrate metabolism during prolonged exercise and recovery: interactions between pyruvate dehydrogenase, fatty acids, and amino acidsJ Appl Physiol2006100182218301:CAS:528:DC%2BD28XlvVOjtbk%3Dhttps://doi.org/10.1152/japplphysiol.00571.200516424076
PubMedGoogle Scholar
SumidaKDDonovanCMEnhanced hepatic gluconeogenic capacity for selected precursors after endurance trainingJ Appl Physiol199579188318881:CAS:528:DyaK28XhtVyitbo%3D8847248
PubMed Web of Science ®Google Scholar
FrancesconiRPSawkaMNPandolfKBHubbardRWYoungAJMuzaSPlasma renin and aldosterone responses at graded hypohydration levels during exercise-heat stressJ Appl Physiol198559185518601:CAS:528:DyaL28Xmt1eltw%3D%3D3908440
PubMedGoogle Scholar
MontainSJLairdJELatzkaWASawkaMNAldosterone and vasopressin responses in the heat: hydration level and exercise intensity effectsMed Sci Sports Exerc1997296616681:CAS:528:DyaK2sXjtl2msbs%3Dhttps://doi.org/10.1097/00005768-199705000-000129140904
PubMed Web of Science ®Google Scholar
KenefickRWMareshCMArmstrongLERiebeDEchegarayMECastellaniJWRehydration with fluid of varying tonicities: effects on fluid regulatory hormones and exercise performance in the heatJ Appl Physiol2007102189919051:CAS:528:DC%2BD2sXmt1aqsLo%3Dhttps://doi.org/10.1152/japplphysiol.00920.200617317877
PubMedGoogle Scholar
KoshimizuTANasaYTanoueAOikawaRKawaharaYKiyonoYAdachiTTanakaTKuwakiTMoriTTakeoSOkamuraHTsujimotoGV1a vasopressin receptors maintain normal blood pressure by regulating circulating blood volume and baroreflex sensitivityProc Natl Acad Sci20061037807781214725261:CAS:528:DC%2BD28XlsVGks7c%3Dhttps://doi.org/10.1073/pnas.060087510316682631
PubMed Web of Science ®Google Scholar
BrandenbergerGCandasVFolleniusMLibertJPKahnJMVascular fluid shifts and endocrine response to exercise in the heatEur J Appl Physiol1986551231291:CAS:528:DyaL28XkvFWqt7k%3Dhttps://doi.org/10.1007/BF00714993
Google Scholar
ConvertinoVAKeilLCGreenleafJEPlasma volume, renin, and vasopressin responses to graded exercise after trainingJ Appl Physiol1983545085141:CAS:528:DyaL3sXhtVWrtrY%3D6339451
PubMed Web of Science ®Google Scholar
CastellLMPoortmansJRLeClercqRBrassuerMDuchateauJNewsholmeEASome aspects of the acute phase response after a marathon race, and the effects of glutamine supplementationEur J Appl Physiol19977547531:CAS:528:DyaK2sXivVegtLo%3Dhttps://doi.org/10.1007/s004210050125
PubMed Web of Science ®Google Scholar
MilesMPAndringJMPearsonSDGordonLKKasperCDepnerCMKiddJRDiurnal variation, response to eccentric exercise, and association of inflammatory mediators with muscle damage variablesJ Appl Physiol20081044514581:CAS:528:DC%2BD1cXjtleltLo%3Dhttps://doi.org/10.1152/japplphysiol.00572.200718079262
PubMed Web of Science ®Google Scholar
NeubauerOKonigDWagnerKHRecovery after an ironman triathlon: sustained inflammatory responses and muscular stressEur J Appl Physiol2008104417426https://doi.org/10.1007/s00421-008-0787-618548269
PubMed Web of Science ®Google Scholar
MahmCSjodinBSjobergBLenderiRRenstromPLundbergIEEkblomBLeukocytes, cytokines, growth factors and hormones in skeletal muscle and blood after uphill or downhill runningJ Physiol20045569831000https://doi.org/10.1113/jphysiol.2003.056598
Google Scholar
GleesonMAlmeyJBrooksSCaveRLewisAGriffithsHHaematological and acute-phase responses associated with delayed-onset muscle soreness in humansEur J Applied Physiol Occup Physiol1995711371421:STN:280:DyaK28%2FkvFylsA%3D%3Dhttps://doi.org/10.1007/BF00854970
PubMed Web of Science ®Google Scholar
HiscockNPetersenEWKrzywkowskiKBozaJHalkjaer-KristensenJPedersenBKGlutamine supplementation further enhances exercise-induced plasma IL-6J Appl Physiol2003951451481:CAS:528:DC%2BD3sXlvVSktr8%3Dhttps://doi.org/10.1152/japplphysiol.00471.200212611772
PubMed Web of Science ®Google Scholar
JonsdottirIHSchjerlingPOstrowskiKAspSRichterEAPedersenBKMuscle contractions induce interleukin-6 mRNA production in rat skeletal musclesJ Physiol200052815716322701261:CAS:528:DC%2BD3cXnslWqt70%3Dhttps://doi.org/10.1111/j.1469-7793.2000.00157.x11018114
PubMed Web of Science ®Google Scholar
NyboLNielsenBPedersenBKMollerKSecherNHInterleukin-6 release from the human brain during prolonged exerciseJ Physiol200254299199522904441:CAS:528:DC%2BD38XmsFOlsLk%3Dhttps://doi.org/10.1113/jphysiol.2002.02228512154196
PubMed Web of Science ®Google Scholar
PedersenBKSteensbergAFischerCKellerCOstrowskiKSchjerlingPExercise and cytokines with particular focus on muscle derived IL-6Exerc Immunol Rev200181831
Google Scholar
RidkerPMCushmanMStampferMJTracyRPHennekensCHInflammation, aspirin, and the risk of cardiovascular disease in apparently healthy menN Eng J Med19973369739791:CAS:528:DyaK2sXisFOrtL0%3Dhttps://doi.org/10.1056/NEJM199704033361401
PubMed Web of Science ®Google Scholar
PhillipsTChildsACDreonDMPhinneySLeeuwenburghCA dietary supplement attenuates IL-6 and CRP after eccentric exercise in untrained malesMed Sci Sports Exerc200335203220371:CAS:528:DC%2BD3sXpsVGju7w%3Dhttps://doi.org/10.1249/01.MSS.0000099112.32342.1014652498
PubMed Web of Science ®Google Scholar
Robson-AnsleyPBarwoodMEglinCAnsleyLThe effect of carbohydrate ingestion on the interleukin-6 response to a 90-minute run time trialInt J Sports Physiol Perf20094186194
PubMed Web of Science ®Google Scholar
Andreasen AS, Pedersen-Skovsgaard T, Mortensen OH, van Hall G, Moseley PL, Pedersen BK: The effect of glutamine infusion on the inflammatory response and HSP70 during human experimental endotoxaemia. Crit Care. 2009, R7-10.1186/cc7696. 13
Google Scholar
PetersenAMWPedersenBKThe role of IL-6 in mediating the anti-inflammatory effects of exerciseJ Physiol Pharmacol200657Suppl435117242490
PubMedGoogle Scholar
AllesioHMExercise-induced oxidative stressMed Sci Sports Exerc199325218224
Google Scholar
PaikIYJeongMHJinHEKimYISuhARChoSYRohHTJinCHSuhSHFluid replacement following dehydration reduces oxidative stress during recoveryBiochem Biophys Res Comm20093831031071:CAS:528:DC%2BD1MXltFWgs78%3Dhttps://doi.org/10.1016/j.bbrc.2009.03.13519344695
PubMed Web of Science ®Google Scholar
HoffmanJRRatamessNATranchinaCPRashtiSLKangJFaigenbaumADEffect of Protein Ingestion on Recovery Indices Following a Resistance Training Protocol in Strength/Power AthletesAmino Acids2009
Google Scholar
BottecchiaDBordinDMartinoREffect of different kinds of physical exercise on the plasmatic testosterone level of normal adult malesSports Med198727151:CAS:528:DyaL1cXktlahtbg%3D
Google Scholar
GalboHHammerLPetersonIBChristensenNJBicNThyroid and testicular hormone responses to gradual and prolonged exercise in manJ Appl Physiol1977361011061:CAS:528:DyaE2sXhtlOiu7Y%3Dhttps://doi.org/10.1007/BF00423117
Google Scholar
HoffmanJRMareshCMArmstrongLEGabareeCLBergeronMFKenefickRWCastellaniJWAhlquistLEWardAEffects of hydration state on plasma testosterone, cortisol, and catecholamine concentrations before and during mild exercise at elevated temperatureEur J Appl Physiol1994692943001:CAS:528:DyaK28XmsVKhhttps://doi.org/10.1007/BF00392033
PubMed Web of Science ®Google Scholar
BrandenbergerGCandasVFolleniusMKahnJMThe influence of initial state of hydration on endocrine responses to exercise in the heatEur J Appl Physiol1989586746791:STN:280:DyaL1M3ns1egtg%3D%3Dhttps://doi.org/10.1007/BF00418516
Web of Science ®Google Scholar
MareshCMWhittleseyMJArmstrongLEYamamotoLMJudelsonDAFishKECasaDJKavourasSACastracaneVDEffect of hydration state on testosterone and cortisol responses to training-intensity exercise in collegiate runnersInt J Sports Med2006277657701:CAS:528:DC%2BD28XhtFynsrrPhttps://doi.org/10.1055/s-2005-87293217006802
PubMedGoogle Scholar
JudelsonDAMareshCMYamamotoLMFerrellMJArmstrongLEKraemerWJVolekJSSpieringBACasaDJAndersonJMEffect of hydration state on resistance exercise-induced endocrine markers of anabolism, catabolism, and metabolismJ Appl Physiol2008105816824https://doi.org/10.1152/japplphysiol.01010.200718617629
PubMed Web of Science ®Google Scholar
GordonSEKraemerWJVosNHLynchJMKnuttgenHGEffect of acid-base balance on the growth hormone response to acute high-intensity cycle exerciseJ Appl Physiol1994768218291:CAS:528:DyaK2cXjtFKiu74%3D8175595
PubMed Web of Science ®Google Scholar
PeyreigneCBouixDFédouCMercierJEffect of hydration on exercise-induced growth hormone responseEur J Endocrinol20011454454501:CAS:528:DC%2BD3MXns1Gju7o%3Dhttps://doi.org/10.1530/eje.0.145044511581003
PubMedGoogle Scholar
SuminskiRRRobertsonRJGossGLArsianianSKangJDaSilvaSUtterACMetzKFAcute effect of amino acid ingestion and resistance exercise on plasma growth hormone concentration in young menInt J Sports Nutr1997748601:CAS:528:DyaK2sXitVeis7g%3D
Google Scholar
WelbourneTCIncreased plasma bicarbonate and growth hormone after an oral glutamine loadAm J Clin Nutr199561105810611:CAS:528:DyaK2MXlvFClur4%3D7733028
PubMed Web of Science ®Google Scholar
DuskaFFricMPazoutJWaldaufPTumaPPachlJFrequent intravenous pulses of growth hormone together with alanylglutamine supplementation in prolonged critical illness after multiple trauma: effects on glucose control, plasma IGF-1 and glutamineGrowth Horm IGF Res20081882871:CAS:528:DC%2BD1cXitVensb4%3Dhttps://doi.org/10.1016/j.ghir.2007.07.00317709266
PubMedGoogle Scholar

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.

People also read
Recommended articles
Cited by

To cite this article:

Reference style: APA Chicago Harvard

Citation copied to clipboard

Reference styles above use APA (6th edition), Chicago (16th edition) & Harvard (10th edition)

Download citation

Download a citation file in RIS format that can be imported by citation management software including EndNote, ProCite, RefWorks and Reference Manager.

Choose format: RIS BibTex RefWorks Direct Export

Choose options: Citation Citation & abstract Citation & references

Examination of the efficacy of acute L-alanyl-L-glutamine ingestion during hydration stress in endurance exercise

References

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Examination of the efficacy of acute L-alanyl-L-glutamine ingestion during hydration stress in endurance exercise

References

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date