Search in:

Advanced search

Journal of the International Society of Sports Nutrition Volume 15, 2018 - Issue 1

Submit an article Journal homepage

Open access

1,451

Views

CrossRef citations to date

Altmetric

Research Article

Biotin and chromium histidinate improve glucose metabolism and proteins expression levels of IRS-1, PPAR-γ, and NF-κB in exercise-trained rats

Mine Turgut1 Faculty of Sports SciencesFirat UniversityElazigTurkey

Vedat Cinar1 Faculty of Sports SciencesFirat UniversityElazigTurkey

Ragip Pala1 Faculty of Sports SciencesFirat UniversityElazigTurkey

Mehmet Tuzcu2 Department of Biology, Faculty of ScienceFirat University23119ElazigTurkey

Cemal Orhan3 Department of Animal Nutrition, Faculty of Veterinary MedicineFirat UniversityElazigTurkey

Hafize Telceken3 Department of Animal Nutrition, Faculty of Veterinary MedicineFirat UniversityElazigTurkey

Nurhan Sahin3 Department of Animal Nutrition, Faculty of Veterinary MedicineFirat UniversityElazigTurkey

Patrick Brice Defo Deeh4 Animal Physiology and Phytopharmacology LaboratoryUniversity of DschangDschangCameroon

James R. Komorowski5 Scientific and Regulatory AffairsNutrition 21 Inc, 1 Manhattanville Road10577PurchaseNYUSA

Kazim Sahin3 Department of Animal Nutrition, Faculty of Veterinary MedicineFirat UniversityElazigTurkeyCorrespondence[email protected]

https://orcid.org/0000-0001-9542-5244

show all

Article: 45 | Published online: 01 Apr 2022

Cite this article
https://doi.org/10.1186/s12970-018-0249-4
CrossMark

Full Article
Figures & data
References
Citations
Metrics
Licensing
Reprints & Permissions
View PDF PDF

References

MoonHSLeeHGSeoJHChungCSKimTGChoiYJChoCSAntiobesity effect of PEGylated conjugated linoleic acid on high fat diet induced obese C57BL/6J(Ob/Ob) mice; attenuation of insulin resistance and enhancement of antioxidant defensesJ Nutr Biochem200920 187 194 1:CAS:528:DC%2BD1MXhtlKrtrc%3D https://doi.org/10.1016/j.jnutbio.2008.02.001
Web of Science ®Google Scholar
FryAPutrinoDExercise decreases cardiovascular risk factors: now what?Int J Cardiol2018254 340 341 https://doi.org/10.1016/j.ijcard.2017.12.023
Web of Science ®Google Scholar
GualanoBPintoALPerondiMBRoschelHSallumAMHayashiAPSolisMYSilvaCATherapeutic effects of exercise training in patients with pediatric rheumatic diseasesRev Bras Reumatol201151 490 496 https://doi.org/10.1590/S0482-50042011000500008
PubMed Web of Science ®Google Scholar
PaillardTPreventive effects of regular physical exercise against cognitive decline and the risk of dementia with age advancementSports Med Open20151 20 https://doi.org/10.1186/s40798-015-0016-x
PubMedGoogle Scholar
KiensBSkeletal muscle lipid metabolism in exercise and insulin resistancePhysiol Rev200686 205 243 1:CAS:528:DC%2BD28XhtlKntr4%3D https://doi.org/10.1152/physrev.00023.2004
PubMed Web of Science ®Google Scholar
TurcotteLPFisherJSSkeletal muscle insulin resistance: roles of fatty acid metabolism and exercisePhys Ther200888 1279 1296 https://doi.org/10.2522/ptj.20080018
PubMed Web of Science ®Google Scholar
Ramos-JiménezAHernández-TorresRPTorres-DuránPVRomero-GonzalezJMascherDPosadas-RomeroCJuárez-OropezaMAThe respiratory exchange ratio is associated with fitness indicators both in trained and untrained men: a possible application for people with reduced exercise toleranceClin Med Circ Respirat Pulm Med20082 1 9 21157516 2990231
PubMedGoogle Scholar
O’GormanDJKrookAExercise and the treatment of diabetes and obesityEndocrinol Metab Clin N Am200837 887 903 https://doi.org/10.1016/j.ecl.2008.07.006
PubMed Web of Science ®Google Scholar
BruunJMHelgeJWRichelsenBStallknechtBDiet and exercise reduce low-grade inflammation and macrophage infltration in adipose tissue but not in skeletal muscle in severely obese subjectsAm J Physiol Endocrinol Metab2006290 E961 E967 1:CAS:528:DC%2BD28XkvFKlsro%3D https://doi.org/10.1152/ajpendo.00506.2005
PubMed Web of Science ®Google Scholar
IkedaSTamuraYKakehiSTakenoKKawaguchiMWatanabeTSatoFOgiharaTKanazawaAFujitaniYKawamoriRWatadaHExercise-induced enhancement of insulin sensitivity is associated with accumulation of M2-polarized macrophages in mouse skeletal muscleBiochem Biophys Res Commun2013441 36 41 1:CAS:528:DC%2BC3sXhs1yqtLbJ https://doi.org/10.1016/j.bbrc.2013.10.005
Web of Science ®Google Scholar
OliveiraAGAraujoTGCarvalhoBMGuadagniniDRochaGZBagarolliRACarvalheiraJBSaadMJAcute exercise induces a phenotypic switch in adipose tissue macrophage polarization in diet-induced obese ratsObes (Silver Spring)201321 2545 2556 1:CAS:528:DC%2BC3sXhvVyjsLzK https://doi.org/10.1002/oby.20402
Web of Science ®Google Scholar
PanXRLiGWHuYHWangJXYangWYAnZXHuZXLinJXiaoJZCaoHBLiuPAJiangXGJiangYYWangJPZhengHZhangHBennettPHHowardBVEffects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance: the da Qing IGT and diabetes studyDiabetes Care199720 537 544 1:STN:280:DyaK2s3ltFaqtw%3D%3D https://doi.org/10.2337/diacare.20.4.537
PubMed Web of Science ®Google Scholar
ErikssonJLindströmJValleTAunolaSHämäläinenHIlanne-ParikkaPKeinänen- KiukaanniemiSLaaksoMLauhkonenMLehtoPLehtonenALouherantaAMannelinMMartikkalaVRastasMSundvallJTurpeinenAViljanenTUusitupaMTuomilehtoJPrevention of type II diabetes in subjects with impaired glucose tolerance: the diabetes prevention study (DPS) in Finland. Study design and 1- year interim report on the feasibility of the lifestyle intervention programmeDiabetologia199942 793 801 1:CAS:528:DyaK1MXktF2lsLg%3D https://doi.org/10.1007/s001250051229
PubMed Web of Science ®Google Scholar
KnowlerWCBarrett-ConnorEFowlerSEHammanRFLachinJMWalkerEANathanDMDiabetes prevention program research group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metforminN Engl J Med2002346 393 403 1:CAS:528:DC%2BD38XhtVWqurc%3D https://doi.org/10.1056/NEJMoa012512
PubMed Web of Science ®Google Scholar
PavleticAJPaoMWrightMEExercise-induced elevation of liver enzymes in a healthy female research volunteerPsychosomatics201556 604 606 https://doi.org/10.1016/j.psym.2015.03.002
Web of Science ®Google Scholar
LeonArthur S.CasalDavidJacobsDavidEffects of 2,000 kcal per Week of Walking and Stair Climbing on Physical Fitness and Risk Factors for Coronary Heart DiseaseJournal of Cardiopulmonary Rehabilitation199616 3 183 192 1:STN:280:DyaK28zlsVWkug%3D%3D https://doi.org/10.1097/00008483-199605000-00006
Google Scholar
BosakKAPapaVBBrucksMGSavageCRDonnellyJEMartinLENovel biomarkers of physical activity maintenance in midlife women: preliminary investigationBiores Open Access20187 39 46 https://doi.org/10.1089/biores.2018.0010
Web of Science ®Google Scholar
Dieli-ConwrightCMCourneyaKSDemark-WahnefriedWSamiNLeeKBuchananTASpicerDVTripathyDBernsteinLMortimerJEEffects of aerobic and resistance exercise on metabolic syndrome, sarcopenic obesity, and circulating biomarkers in overweight or obese survivors of breast cancer: a randomized controlled trialJ Clin Oncol201836 875 883 https://doi.org/10.1200/JCO.2017.75.7526
PubMed Web of Science ®Google Scholar
SaadMJArakiEMiralpeixMRothenbergPLWhiteMFKahnCRRegulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistanceJ Clin Invest199290 1839 1849 1:CAS:528:DyaK3sXjtlarsA%3D%3D https://doi.org/10.1172/JCI116060
PubMed Web of Science ®Google Scholar
HallakouSDoare´LFoufelleFKergoatMGuerre-MilloMBerthaultMFDugailIMorinJAuwerxJFerréPPioglitazone induces in vivo adipocyte differentiation in the obese Zucker fa/fa ratDiabetes199746 1393 1399 1:CAS:528:DyaK2sXlvFenurw%3D https://doi.org/10.2337/diabetes.46.9.1393
PubMed Web of Science ®Google Scholar
ThomasAWDaviesNAMoirHWatkeysLRuffinoJSIsaSAButcherLRHughesMGMorrisKWebbRExercise-associated generation of PPARγ ligands activates PPARγ signaling events and upregulates genes related to lipid metabolismJ Appl Physiol2012112 806 815 1:CAS:528:DC%2BC38Xls12nsbg%3D https://doi.org/10.1152/japplphysiol.00864.2011
PubMed Web of Science ®Google Scholar
KirwanJPdel-AguilaLFHernandezJMWilliamsonDLO'GormanDJLewisRKrishnanRKRegular exercise enhances insulin activation of IRS-1-associated PI3- kinase in human skeletal muscleJ Appl Physiol200088 797 803 1:CAS:528:DC%2BD3cXht12isLs%3D https://doi.org/10.1152/jappl.2000.88.2.797
PubMed Web of Science ®Google Scholar
TownsendJRStoutJRJajtnerARChurchDDBeyerKSOliveiraLPLa MonicaMBRiffeJJMuddleTWBakerKMFukudaDHRobertsMDHoffmanJRResistance exercise increases intramuscular NF-κb signaling in untrained malesEur J Appl Physiol2016116 2103 2111 1:CAS:528:DC%2BC28XhsVyis7bP https://doi.org/10.1007/s00421-016-3463-2
Web of Science ®Google Scholar
LefaviRGAndersonRAKeithREWilsonGDMcMillanJLStoneMHEfficacy of chromium supplementation in athletes: emphasis on anabolismInt J Sport Nutr19922 111 122 1:STN:280:DyaK3s3jtVaktQ%3D%3D https://doi.org/10.1123/ijsn.2.2.111
Web of Science ®Google Scholar
AlbarracinCAFuquaBCEvansJLGoldfineIDChromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetesDiabetes Metab Res Rev200824 41 51 1:CAS:528:DC%2BD1cXitFKmtrs%3D https://doi.org/10.1002/dmrr.755
PubMed Web of Science ®Google Scholar
LamsonDWPlazaSMThe safety and efficacy of high-dose chromiumAltern Med Rev20027 218 235 12126463
PubMedGoogle Scholar
AndersonRAPolanskyMMBrydenNAStability and absorption of chromium and absorption of chromium histidinate complexes by humansBiol Trace Elem Res2004101 211 218 1:CAS:528:DC%2BD2cXhtVKhtLfK https://doi.org/10.1385/BTER:101:3:211
PubMed Web of Science ®Google Scholar
TuzcuMSahinNOrhanCAgcaCAAkdemirFTuzcuZJames KomorowskiJSahinKImpact of chromium histidinate on high fat diet induced obesity in ratsNutr Metab (Lond)20118 28 1:CAS:528:DC%2BC3MXmtVKqsrY%3D https://doi.org/10.1186/1743-7075-8-28
Web of Science ®Google Scholar
UlasMOrhanCTuzcuMOzercanIHSahinNGencogluHKomorowskiJRKazim SahinKAnti-diabetic potential of chromium histidinate in diabetic retinopathy ratsBMC Complement Altern Med201515 16 https://doi.org/10.1186/s12906-015-0537-3
PubMed Web of Science ®Google Scholar
RialesRAlbrinkMJEffect of chromium chloride supplementation on glucose tolerance and serum lipids including high-density lipoprotein of adult menAm J Clin Nutr198134 2670 2678 1:CAS:528:DyaL38XltFSgug%3D%3D https://doi.org/10.1093/ajcn/34.12.2670
PubMed Web of Science ®Google Scholar
CefaluWTHuFBRole of chromium in human health and in diabetesDiabetes Care200427 2741 2751 1:CAS:528:DC%2BD2cXhtVKis7zK https://doi.org/10.2337/diacare.27.11.2741
PubMed Web of Science ®Google Scholar
Fernandez-MejiaCPharmacological effects of biotinJ Nutr Biochem200516 424 427 1:CAS:528:DC%2BD2MXlvVWlsbs%3D https://doi.org/10.1016/j.jnutbio.2005.03.018
PubMed Web of Science ®Google Scholar
KomorowskiJRde la HarpeJCefaluWTZhangXHWangZQGreenbergDJCR: LA-cp rats show improved lipid profiles in response to diets containing chromium picolinate and biotin [abstract-80]SSIB Program2001 San Antonio TX: Society for the study of ingestive behavior 41
Google Scholar
JuturuVRuelleAHudsonMSKomorowskiJRImproved glycemic control after diabetes education and chromium picolinate/biotin supplementation in type 2 diabetes: results from patients experience pilot programTrace Elem Electrolytes200623 66 72 1:CAS:528:DC%2BD28XitFOktL4%3D https://doi.org/10.5414/TEP23066
Web of Science ®Google Scholar
WangZQZhangXHRussellJCHulverMCefaluWTChromium picolinate enhances skeletal muscle cellular insulin signaling in vivo in obese, insulin-resistant JCR: LA-cp ratsJ Nutr2006136 415 420 1:CAS:528:DC%2BD28Xht1WisLg%3D https://doi.org/10.1093/jn/136.2.415
Web of Science ®Google Scholar
EEC. Council Directive 86/609/EEC on the approximation of laws, regulations and administrative provisions of the member states regarding the protection of animals used for experimental and other scientific purposes. Official J European Communities. 1986:L358.
Google Scholar
ReevesPGNielsenFHFaheyGCJrAIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent dietJ Nutr1993123 1939 1951 1:CAS:528:DyaK2cXltlegsw%3D%3D https://doi.org/10.1093/jn/123.11.1939
PubMed Web of Science ®Google Scholar
OrhanCAkdemirFSahinNTuzcuMKomorowskiJRHayirliASahinKChromium histidinate protects against heat stress by modulating the expression of hepatic nuclear transcription factors in quailBr Poult Sci201253 828 835 1:CAS:528:DC%2BC38Xhs1Ohu7bI https://doi.org/10.1080/00071668.2012.747084
PubMed Web of Science ®Google Scholar
RathmanSCGregoryJFMcMahonRJPharmacological biotin supplementation maintains biotin status and function in rats administered dietary carbamazepineJ Nutr2003133 2857 2862 1:CAS:528:DC%2BD3sXntlaks74%3D https://doi.org/10.1093/jn/133.9.2857
Web of Science ®Google Scholar
LewisBRathmanSMcMahonRDietary biotin intake modulates the pool of free and protein-bound biotin in rat liverJ Nutr2001131 2310 2315 1:CAS:528:DC%2BD3MXmslGmt7k%3D https://doi.org/10.1093/jn/131.9.2310
Web of Science ®Google Scholar
PektasMehmet BilgehanKocaHalit BugraSadiGokhanAkarFatmaDietary Fructose Activates Insulin Signaling and Inflammation in Adipose Tissue: Modulatory Role of ResveratrolBioMed Research International20162016 1 10 https://doi.org/10.1155/2016/8014252
Web of Science ®Google Scholar
AngETGomez-PinillaFPotential therapeutic effects of exercise to the brainCurr Med Chem200714 2564 2571 1:CAS:528:DC%2BD2sXhtFGmsrrO https://doi.org/10.2174/092986707782023280
PubMed Web of Science ®Google Scholar
AzainMJHausmanDBSiskMBFlattWPJewellDEDietary conjugated linoleic acid reduces fat adipose tissue cell size rather than cell numberJ Nutr2000130 1548 1554 1:CAS:528:DC%2BD3cXjsl2hurw%3D https://doi.org/10.1093/jn/130.6.1548
PubMed Web of Science ®Google Scholar
WendelAAPurushothamALiuLFBeluryMAConjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in Ob/Ob miceJ Lipid Res200849 98 106 1:CAS:528:DC%2BD1cXktVWqug%3D%3D https://doi.org/10.1194/jlr.M700195-JLR200
Web of Science ®Google Scholar
LeonASSanchezOAResponse of blood lipids to exercise training alone or combined with dietary interventionMed Sci Sports Exerc200133 S502 S515 1:CAS:528:DC%2BD3MXkslOhtL8%3D https://doi.org/10.1097/00005768-200106001-00021
PubMed Web of Science ®Google Scholar
ZoladzJAMajerczakJZeligowskaEMencelJJaskolskiAJaskolskaA et al Moderate-intensity interval training increases serum brain-derived neurotrophic factor level and decreases inflammation in Parkinson’s disease patientsJ Physiol Pharmacol201465 441 448 1:CAS:528:DC%2BC2cXhsVShtr7M 24930517
PubMed Web of Science ®Google Scholar
MarusiakJZeligowskaEMencelJKisiel-SajewiczKMajerczakJZoladzJAJaskólskiAJaskólskaAInterval training-induced alleviation of rigidity and hypertonia in patients with Parkinson’s disease is accompanied by increased basal serum brain-derived neurotrophic factorJ Rehabil Med201547 372 375 https://doi.org/10.2340/16501977-1931
PubMed Web of Science ®Google Scholar
YeghiazaryanKSchildHHGolubnitschajaOChromium-picolinate therapy in diabetes care: individual outcomes require new guidelines and navigation by predictive diagnosticsInfect Disord Drug Targets201212 332 339 1:CAS:528:DC%2BC3sXlt12gsg%3D%3D https://doi.org/10.2174/187152612804142215
Google Scholar
StaniekHKrejpcioZThe effects of supplementary Cr3 (chromium (III) propionate complex) on the mineral status in healthy female ratsBiol Trace Elem Res2017180 90 99 1:CAS:528:DC%2BC2sXktVGrs7k%3D https://doi.org/10.1007/s12011-017-0985-3
Web of Science ®Google Scholar
DogukanATuzcuMJuturuVCikimGOzercanIKomorowskiJSahinKEffects of chromium histidinate on renal function, oxidative stress, and heat-shock proteins in fat-fed and streptozotocin-treated ratsJ Ren Nutr201020 112 120 1:CAS:528:DC%2BC3MXksFGmu74%3D https://doi.org/10.1053/j.jrn.2009.04.009
Web of Science ®Google Scholar
GrantKEChandlerRMCastleALIvyJLChromium and exercise training: effect on obese womenMed Sci Sports Exerc199729 992 998 1:CAS:528:DyaK2sXlvV2rtbc%3D https://doi.org/10.1097/00005768-199708000-00003
PubMed Web of Science ®Google Scholar
OsadaKKomaiMSugiyamaKUrayamaNFurukawaYExperimental study of fatigue provoked by biotin deficiency in miceInt J Vitam Nutr Res200474 334 340 1:CAS:528:DC%2BD2MXhvFemsA%3D%3D https://doi.org/10.1024/0300-9831.74.5.334
Web of Science ®Google Scholar
SingerGMGeohasJThe effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trialDiabetes Technol Ther20068 636 643 1:CAS:528:DC%2BD28Xht1Smt7bM https://doi.org/10.1089/dia.2006.8.636
PubMed Web of Science ®Google Scholar
GeohasJDalyAJuturuVFinchMKomorowskiJRChromium picolinate and biotin combination reduces atherogenic index of plasma in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trialAm J Med Sci2007333 145 153 https://doi.org/10.1097/MAJ.0b013e318031b3c9
PubMed Web of Science ®Google Scholar
SahinKOnderciMSahinNGursuMFVijayaJKucukOEffects of dietary combination of chromium and biotin on egg production, serum metabolites, and egg yolk mineral and cholesterol concentrations in heat-distressed laying quailsBiol Trace Elem Res2004101 181 192 1:CAS:528:DC%2BD2cXhtVeqtLrL https://doi.org/10.1385/BTER:101:2:181
PubMed Web of Science ®Google Scholar
SahinNSahinKOnderciMGursuMFCikimGVijayaJKucukOChromium picolinate, rather than biotin, alleviates performance and metabolic parameters in heat-stressed quailBr Poult Sci200546 457 463 1:CAS:528:DC%2BD2MXpslyrsb4%3D https://doi.org/10.1080/00071660500190918
PubMed Web of Science ®Google Scholar
OnderciMSahinKSahinNCikimGVijayaJKucukOEffects of dietary combination of chromium and biotin on growth performance, carcass characteristics, and oxidative stress markers in heat-distressed Japanese quailBiol Trace Elem Res2005106 165 176 1:CAS:528:DC%2BD2MXps12htrk%3D https://doi.org/10.1385/BTER:106:2:165
PubMed Web of Science ®Google Scholar
ShengXZhangYGongZHuangCZangYQImproved insulin resistance and lipid metabolism by cinnamon extract through activation of peroxisome proliferator-activated receptorsPPAR Res20082008 581 348 https://doi.org/10.1155/2008/581348
Web of Science ®Google Scholar
GrimaldiPARegulatory role of peroxisome proliferator-activated receptor delta (PPAR delta) in muscle metabolism. A new target for metabolic syndrome treatment?Biochimie200587 5 8 1:CAS:528:DC%2BD2MXhslCnt7w%3D https://doi.org/10.1016/j.biochi.2004.11.009
PubMed Web of Science ®Google Scholar
TaoLBeiYLinSZhangHZhouYJiangJChenPShenSXiaoJLiXExercise training protects against acute myocardial infarction via improving myocardial energy metabolism and mitochondrial biogenesisCell Physiol Biochem201537 162 175 1:CAS:528:DC%2BC2MXhsVOnsbvM https://doi.org/10.1159/000430342
Google Scholar
PalaRagıpGencEyupTuzcuMehmetOrhanCemalSahinNurhanErBesirCinarVedatSahinKazimL-Carnitine supplementation increases expression of PPAR-γ and glucose transporters in skeletal muscle of chronically and acutely exercised ratsCellular and Molecular Biology201864 1 1 https://doi.org/10.14715/cmb/2018.64.1.1
Web of Science ®Google Scholar
SahinKTuzcuMOrhanCSahinNKucukOOzercanIHJuturuVKomorowskiJRAnti-diabetic activity of chromium picolinate and biotin in rats with type 2 diabetes induced by high-fat diet and streptozotocinBr J Nutr2013110 197 205 1:CAS:528:DC%2BC3sXpsFGrsb0%3D https://doi.org/10.1017/S0007114512004850
Web of Science ®Google Scholar
ArakiELipesMAPattiMEBrüningJCHaagB3rdJohnsonRSKahnCRAlternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 geneNature1994372 186 190 1:CAS:528:DyaK2cXmvFehu7Y%3D https://doi.org/10.1038/372186a0
PubMed Web of Science ®Google Scholar
WithersDJGutierrezJSToweryHBurksDJRenJMPrevisSZhangYBernalDPonsSShulmanGIBonner-WeirSWhiteMFDisruption of IRS-2 causes type 2 diabetes in miceNature1998391 900 904 1:CAS:528:DyaK1cXhsFyksr0%3D https://doi.org/10.1038/36116
PubMed Web of Science ®Google Scholar
ChibalinAVYuMRyderJWSongXMGaluskaDKrookAWallberg- HenrikssonHZierathJRExercise-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: differential effects on insulin-receptor substrates 1 and 2Proc Natl Acad Sci U S A200097 38 43 1:CAS:528:DC%2BD3cXjvVCltA%3D%3D https://doi.org/10.1073/pnas.97.1.38
PubMed Web of Science ®Google Scholar
JainSKCroadJLVelusamyTRainsJLBullRChromium dinicocysteinate supplementation can lower blood glucose, CRP, MCP-1, ICAM-1, creatinine, apparently mediated by elevated blood vitamin C and adiponectin and inhibition of NFkappaB, Akt, and Glut-2 in livers of zucker diabetic fatty ratsMol Nutr Food Res201054 1371 1380 1:CAS:528:DC%2BC3cXhtFWqtb3J https://doi.org/10.1002/mnfr.200900177
PubMed Web of Science ®Google Scholar
MaYHeMQiangLExercise therapy downregulates the overexpression of TLR4, TLR2, MyD88 and NF-κB after cerebral ischemia in ratsInt J Mol Sci201314 3718 3733 1:CAS:528:DC%2BC3sXjtVKisb4%3D https://doi.org/10.3390/ijms14023718
Web of Science ®Google Scholar
SelcukMYAygenBDogukanATuzcuZAkdemirFKomorowskiJRAtalayMSahinKChromium picolinate and chromium histidinate protects against renal dysfunction by modulation of NF-κB pathway in high-fat diet fed and Streptozotocin- induced diabetic ratsNutr Metab (Lond)20129 30 1:CAS:528:DC%2BC38Xns1GntLk%3D https://doi.org/10.1186/1743-7075-9-30
Web of Science ®Google Scholar
KuhadASachdevaAKChopraKAttenuation of renoinflammatory cascade in experimental model of diabetic nephropathy by sesamolJ Agric Food Chem200957 6123 6128 1:CAS:528:DC%2BD1MXns1ekurw%3D https://doi.org/10.1021/jf901388g
PubMed Web of Science ®Google Scholar
LiuTZhangLJooDSunSCNF-κB signaling in inflammationSignal Transduct Target Ther20172 https://doi.org/10.1038/sigtrans.2017.23
Google Scholar

Share icon
Back to Top

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.

People also read
Recommended articles
Cited by

To cite this article:

Reference style: APA Chicago Harvard

Citation copied to clipboard

Reference styles above use APA (6th edition), Chicago (16th edition) & Harvard (10th edition)

Download citation

Download a citation file in RIS format that can be imported by citation management software including EndNote, ProCite, RefWorks and Reference Manager.

Choose format: RIS BibTex RefWorks Direct Export

Choose options: Citation Citation & abstract Citation & references

Biotin and chromium histidinate improve glucose metabolism and proteins expression levels of IRS-1, PPAR-γ, and NF-κB in exercise-trained rats

References

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Biotin and chromium histidinate improve glucose metabolism and proteins expression levels of IRS-1, PPAR-γ, and NF-κB in exercise-trained rats

References

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date