- 1) Refsum, H., Ueland, P. M., Nygard, O., and Vollset, S. E., Homocysteine and cardiovascular disease. Annu. Rev. Med., 49, 31–62 (1998).
- 2) Selhub, J., Homocysteine metabolism. Annu. Rev. Nutr., 19, 217–246 (1999).
- 3) De Bree, A., Berschuren, W. M., Kromhout, D., Kluijtmans, L. A., and Blom, H. J., Homocysteine determinants and the evidence to what extent homocysteine determine the risk of coronary heart disease. Pharmacol. Rev., 54, 599–618 (2002).
- 4) Graham, I. M., and O’Callaghan, R., Vitamins, homocysteine and cardiovascular risk J. Cardiovasc. Risk, 16, 383–389 (2002).
- 5) Chibata, I., Okumura, K., Takeyama, S., and Kotera, K., Lentinacin: a new hypocholesterolemic substance in Lentinus edodes. Experientia, 25, 1237–1238 (1969).
- 6) Rokujyo, T., Kikuchi, H., Tensho, A., Tsukitani, Y., Takenawa, T., Yoshida, K., and Kamiya, T., Lentisine: a new hypolipidemic agent from a mushroom. Life Sci., 9, 379–385 (1970).
- 7) Sugiyama, K., Akachi, T., and Yamakawa, A., Eritadenine-induced alteration of hepatic phospholipid metabolism in relation to its hypocholesterolemic action in rats. J. Nutr. Biochem., 6, 80–87 (1995).
- 8) Sugiyama, K., Akachi, T., and Yamakawa, A., Hypocholesterolemic action of eritadenine is mediated by a modification of hepatic phospholipid metabolism in rats. J. Nutr., 125, 2134–2144 (1995).
- 9) Sugiyama, K., Yamakawa, A., and Saeki, S., Correlation of suppressed linoleic acid metabolism with the hypocholesterolemic action of eritadenine in rats. Lipids, 32, 859–866 (1997).
- 10) Shimada, Y., Morita, T., and Sugiyama, K., Dietary eritadenine and ethanolamine depress fatty acid desaturase activities by increasing liver microsomal phosphatidylethanolamine in rats. J. Nutr., 133, 758–765 (2003).
- 11) Votruba, I., and Holy, A., Eritadenine-novel type of potent inhibitors of S-adenosyl-L-homocysteine hydrolase. Collect. Czech. Chem. Commun., 47, 167–172 (1982).
- 12) Schanche, J.-S., Schanche, T., Ueland, P. M., Holy, A., and Votruba, I., The effect of aliphatic adenine analogues on S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase in intact rat hepatocytes. Mol. Pharmacol., 26, 553–558 (1984).
- 13) Huang, Y., Komoto, J., Takata, Y., Powell, D. R., Gomi, T., Ogawa, H., Fujioka, M., and Takusagawa, F., Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue D-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with D-eritadenine. J. Biol. Chem., 277, 7477–7482 (2002).
- 14) Shimada, Y., Yamakawa, A., Morita, T., and Sugiyama, K., Effect of dietary eritadenine on the liver microsomal Δ6-desaturase activity and its mRNA in rats. Biosci. Biotechnol. Biochem., 67, 1258–1266 (2003).
- 15) Svardal, A. M., Dijurhuus, R., Refsum, H., and Ueland, P. M., Disposition of homocysteine in rat hepatocytes and in nontransformed and malignant mouse embryo fibroblasts following exposure to inhibitors of S-adenosylhomocysteine catabolism. Cancer Res., 46, 5095–5100 (1986).
- 16) Miller, J. W., Nadeau, M. R., Smith, D., and Selhub, J., Vitamin B-6 deficiency vs folate deficiency: comparison of response to methionine loading. Am. J. Clin. Nutr., 59, 1033–1039 (1994).
- 17) Durand, P., Fortin, L. J., Luissier-Cacan, S., Davignon, J., and Blache, D., Hyperhomocysteinemia induced by folic acid deficiency and methionine load: application of a modified HPLC method. Clin. Chim. Acta, 252, 83–93 (1996).
- 18) Cook, R. J., Horne, D. W., and Wagner, C., Effect of dietary methyl group deficiency on one-carbon metabolism in rats. J. Nutr., 119, 612–617 (1988).
- 19) Mudd, S. H., Finkelstein, J. D., Irreverre, F., and Laster, L., Transsulfuration in mammals. Microassay and tissue distributions of three enzymes of the pathway. J. Biol. Chem., 240, 4382–4392 (1965).
- 20) Einarsson, S., Josefsson, B., and Lagerkvist, S., Detemination of amino acids with 9-fluorenylmethyl chloroformate and reversed-phase high-performance liquid chromatography. J. Chromatogr., 282, 609–618 (1983).
- 21) Dunn, O. J., Multiple comparisons using rank sum. Technometrics, 6, 241–252 (1961).
- 22) Finkelstein, J. D., and Martin, J. J., Methionine metabolism in mammals. Adaptation to methionine excess. J. Biol. Chem., 261, 1582–1587 (1986).
- 23) Aitken, S. M., and Kirsch, J. F., The enzymology of cystathionine biosynthesis: strategies for the control of substrate and reaction specificity. Arch. Biophys. Biochem., 433, 166–175 (2005).
- 24) Stead, L. M., Brosnan, M. E., and Brosnan, J. T., Characterization of homocysteine metabolism in the rat liver. Biochem. J., 350, 685–692 (2000).
- 25) Kreidich, N. M., Hershfield, M. S., Falletta, J. M., Kunney, T. R., Mitchell, B., and Kohler, C., Effects of 2′-deoxycoformycin on homocysteine metabolism in acute lymphoblastic leukemia. Clin. Res., 29, 541A (1981).
- 26) Ubbink, J. B., Becker, P. J., Delport, R., Bester, M., Riezler, R., and Vermaak, W. J., Variability of post-methionine load plasma homocysteine assays. Clin. Chim. Acta, 330, 111–119 (2003).
Full access
Suppression of Methionine-Induced Hyperhomocysteinemia by Dietary Eritadenine in Rats
Reprints and Corporate Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
To request a reprint or corporate permissions for this article, please click on the relevant link below:
Academic Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
Obtain permissions instantly via Rightslink by clicking on the button below:
If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.
Related research
People also read lists articles that other readers of this article have read.
Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.
Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.