- 1) Imamura, T., Crespi, C. L., Thilly, G. W., and Brunengraber, H., Fructose as a carbohydrate source yields stable pH and redox parameters in microcarrier cell culture. Anal. Biochem., 124, 353–358 (1982).
- 2) Petch, D., and Butler, M., The effect of alternative carbohydrates on the growth and antibody production of a murine hybridoma. Appl. Biochem. Biotechnol., 59, 93–104 (1996).
- 3) Fu, Y., Maianu, L., Melbert, B. R., and Garvey, W. T., Facilitative glucose transporter gene expression in human lymphocytes, monocytes, and macrophages: a role for GLUT isoforms 1, 3, and 5 in the immune response and foam cell formation. Blood Cells Mol. Dis., 32, 182–190 (2004).
- 4) Burant, C. F., Takeda, J., Brot-Laroche, E., Bell, G. I., and Davidson, N. O., Fructose transporter in human spermatozoa and small intestine is GLUT5. J. Biol. Chem., 267, 14523–14526 (1992).
- 5) Gouyon, F., Onesto, C., Dalet, V., Pages, G., Leurque, A., and Brot-Laroche, E., Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells: role of cAMP-signaling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2. Biochem. J., 375, 167–174 (2003).
- 6) Matosin-Matekalo, M., Mesoneto, J., Laroche, T. J., Lacasa, M., and Brot-Laroche, E., Glucose and thyroid hormone co-regulate the expression of the intestinal fructose transporter GLUT5. Biochem. J., 339, 233–239 (1999).
- 7) Ballow, M., Wang, X., Xiang, S., and Allen, C., Expression and regulation of nuclear retinoic acid receptors in human lymphoid cells. J. Clin. Immunol., 23, 46–54 (2003).
- 8) Evans, T., Regulation of hematopoiesis by retinoid signaling. Exp. Hematol., 33, 1055–1061 (2005).
- 9) Norata, G. D., Ongari, M., Uboildi, P., Pellegatta, F., and Catapano, A. L., Liver X receptor and retinoic agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells. Int. J. Mol. Med., 16, 717–722 (2005).
- 10) Aotsuka, Y., and Naito, M., Enhancing effects of retinoic acid on monoclonal antibody production of human–human hybridomas. Cell. Immunol., 133, 498–505 (1991).
- 11) Inoue, Y., Fujisawa, M., Shoji, M., Hashizume, S., Katakura, Y., and Shirahata, S., Enhanced antibody production of human-human hybridomas by retinoic acid. Cytotechnology, 33, 83–88 (2000).
- 12) Heyman, R. A., Mangelsdorf, D. J., Dyck, J. A., Stein, R. B., Eichele, G., Evans, R. M., and Thaller, C., 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell, 68, 397–406 (1992).
- 13) Inoue, Y., and Shirahata, S., Increased antibody production by retinoids is related to the fusion partner of human hybridomas. Biosci. Biotechnol. Biochem., 66, 215–217 (2002).
- 14) Kawahara, H., Shirahata, S., Tachibana, H., and Murakami, H., In vitro immunization of human lymphocytes with human lung cancer cell line A549. Hum. Antibod. Hybridomas, 3, 8–13 (1992).
- 15) Shoji, M., Kawamoto, S., Sato, S., Kamei, M., Kato, M., Hashizume, S., Seki, K., Yasumoto, K., Nagashima, A., Nakahashi, H., Suzuki, T., Imai, T., Nomoto, K., and Murakami, H., Specific reactivity of human antibody AE6F4 against cancer cells in tissues and sputa from lung cancer patients. Hum. Antibod. Hybridomas, 5, 116–122 (1994).
- 16) Inoue, Y., Fujisawa, M., Kawamoto, S., Shoji, M., Hashizume, S., Fujii, M., Katakura, Y., and Shirahata, S., Effectiveness of vitamin A acetate for enhancing the production of lung cancer specific monoclonal antibodies. Cytotechnology, 31, 77–83 (1999).
- 17) Mochizuki, K., Sato, S., Kato, M., and Hashizume, S., Enhanced production of human monoclonal antibodies by the use of fructose in serum-free hybridoma culture media. Cytotechnology, 13, 161–173 (1993).
- 18) Reitzer, L. J., Wice, B. M., and Kennell, D., Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells. J. Biol. Chem., 254, 2669–2676 (1979).
- 19) Fujisawa, K., Umesono, K., Kikawa, Y., Shigematsu, Y., Taketo, A., Mayumi, M., and Inuzuka, M., Identification of a response element for vitamin D3 and retinoic acid in the promoter region of the human fructose 1,6-bisphosphatase gene. J. Biochem., 127, 373–382 (2000).
- 20) Desai, D., Michalak, M., Singh, N. K., and Niles, R. M., Inhibition of retinoic acid receptor function and retinoic acid-regulated gene expression in mouse melanoma cells by calreticulin. J. Biol. Chem., 271, 15153–15159 (1996).
- 21) Leid, M., Kastner, P., and Chambon, P., Multiplicity generates diversity in the retinoic acid signaling pathways. TIBS, 17, 427–433 (1992).
- 22) Pinaire, J., Chou, W. Y., Morton, M., You, M., Zeng, Y., Cho, W. K., Galli, A., Everett, L., Breen, H., Dumaual, N., Smith, J. R., and Crabb, D., Identification of a retinoid receptor response element in the human aldehyde dehydrogenase-2 promoter. Alcohol. Clin. Exp. Res., 27, 1860–1866 (2003).
- 23) Boehm, M. F., Zhang, L., Badea, B. A., White, S. K., Mais, D. E., Berger, E., Suto, C. M., Goldman, M. E., and Heyman, R. A., Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids. J. Med. Chem., 37, 2930–2941 (1994).
- 24) Harmon, M. A., Boehm, M. F., Heyman, R. A., and Mangelsdorf, D. J., Activation of mammalian retinoid X receptors by the insect growth regulator methoprene. Proc. Natl. Acad. Sci. USA, 92, 6157–6160 (1995).
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Retinoic Acid Improves a Hybridoma Culture in a Fructose-Based Medium by Up-Regulation of Fructose Incorporation via Retinoid Nuclear Receptors
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