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Bioscience, Biotechnology, and Biochemistry Volume 70, 2006 - Issue 12
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Original Articles

Disruption of ins-11, a Caenorhabditis elegans Insulin-Like Gene, and Phenotypic Analyses of the Gene-Disrupted Animal

Tsuyoshi KAWANODepartment of Biological and Environmental Chemistry, Faculty of Agriculture, Tottori University
,
Ryosuke NAGATOMODepartment of Biological and Environmental Chemistry, Faculty of Agriculture, Tottori University
,
Yasuo KIMURADepartment of Biological and Environmental Chemistry, Faculty of Agriculture, Tottori University
,
Keiko GENGYO-ANDODepartment of Physiology, Tokyo Women’s Medical University School of Medicine;CREST, JST
&
Shohei MITANIDepartment of Physiology, Tokyo Women’s Medical University School of Medicine;CREST, JST
Pages 3084-3087 | Received 29 Aug 2006, Accepted 24 Oct 2006, Published online: 22 May 2014

  • 1) Kimura, K. D., Tissenbaum, H. A., Liu, Y., and Ruvkun, G., daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science, 277, 942–946 (1997).
  • 2) Clancy, D. J., Gems, D., Harshman, L. G., Oldham, S., Stocker, H., Hafen, E., Leevers, S. J., and Partridge, L., Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science, 292, 104–106 (2001).
  • 3) Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Geloen, A., Even, P. C., Cervera, P., and Le Bouc, Y., IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature, 421, 182–187 (2003).
  • 4) Kawano, T., Ito, Y., Ishiguro, M., Takuwa, K., Nakajima, T., and Kimura, Y., Molecular cloning and characterization of a new insulin/IGF-like peptide of the nematode Caenorhabditis elegans. Biochem. Biophys. Res. Commun., 273, 431–436 (2000).
  • 5) Pierce, S. B., Costa, M., Wisotzkey, R., Devadhar, S., Homburger, S. A., Buchman, A., Ferguson, K. C., Heller, J., Platt, D. M., Pasquinelli, A. A., Liu, L. X., Doberstein, S. K., and Ruvkun, G., Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev., 15, 672–686 (2001).
  • 6) Kawano, T., Kobayashi, Y., Tada, T., and Kimura, Y., A new IGF-like peptide regulating the fat metabolism of the nematode Caenorhabditis elegans. In “Peptide Science 2001,” ed. Aoyagi, T., The Japan Peptide Society, Protein Research Foundation, Osaka, pp. 93–96 (2002).
  • 7) Kawano, T., Takuwa, K., Ishiguro, M., Nakajima, T., and Kimura, Y., Cloning and characterization of a Caenorhabditis elegans cDNA encoding a new insulin/IGF-like peptide. Biosci. Biotechnol. Biochem., 67, 2678–2682 (2003).
  • 8) Li, W., Kennedy, S. G., and Ruvkun, G., daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway. Genes Dev., 17, 844–858 (2003).
  • 9) Murphy, C. T., McCarroll, S. T., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., and Kenyon, C., Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature, 424, 277–284 (2003).
  • 10) Simmer, F., Tijsterman, M., Parrish, S., Koushika, S. P., Nonet, M. L., Fire, A., Ahringer, J., and Plasterk, R. H. A., Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi. Curr. Biol., 12, 1317–1319 (2002).
  • 11) Gengyo-Ando, K., and Mitani, S., Characterization of mutations induced by ethyl methanesulfonate, UV, and trimethylpsoralen in the nematode Caenorhabditis elegans. Biochem. Biophys. Res. Commun., 269, 64–69 (2000).
  • 12) Riddle, D. L., and Albert, P. S., Genetic and environmental regulation of dauer larva development. In “C. elegans II,” eds. Riddle, D. L., Blumenthal, T., Meyer, B. J., and Priess, J., R., Cold Spring Harbor Laboratory Press, Plainview, pp. 739–768 (1997).
  • 13) Kawano, T., Kataoka, N., Abe, S., Ohtani, M., Honda, Y., Honda, S., and Kimura, Y., Lifespan extending activity of substances secreted by the nematode Caenorhabditis elegans that include the dauer-inducing pheromone. Biosci. Biotechnol. Biochem., 69, 2479–2481 (2005).
  • 14) Fire, A., Xu, S.-Q., Montgomery, M. K., Kostas, S. A., Driver, S. E., and Mello, C. C., Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature, 391, 806–811 (1998).

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