- 1) Sundram, K., Thiagarajan, T., Gapor, A., and Basiron, Y., Palm tocotrienols: new antioxidants for the new millennium. Inform, 13, 634–640 (2002).
- 2) Serbinova, E., Kagan, V., Han, D., and Packer, L., Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. Free Radic. Biol. Med., 10, 263–275 (1991).
- 3) Suzuki, Y. J., Tsuchiya, M., Wassall, S. R., Choo, Y. M., Govil, G., Kagan, V. E., and Packer, L., Structural and dynamic membrane properties of alpha-tocopherol and alpha-tocotrienol: implication to the molecular mechanism of their antioxidant potency. Biochemistry, 32, 10692–10699 (1993).
- 4) Parker, R. A., Pearce, B. C., Clark, R. W., Gordon, D. A., and Wright, J. J., Tocotrienols regulate cholesterol production in mammalian cells by post- transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J. Biol. Chem., 268, 11230–11238 (1993).
- 5) McIntyre, B. S., Briski, K. P., Gapor, A., and Sylvester, P. W., Antiproliferative and apoptotic effects of tocopherols and tocotrienols on preneoplastic and neoplastic mouse mammary epithelial cells. Proc. Soc. Exp. Biol. Med., 224, 292–301 (2000).
- 6) Sen, C. K., Khanna, S., Roy, S., and Packer, L., Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60c-src kinase activation and death of ht4 neuronal cells. J. Biol. Chem., 275, 13049–13055 (2000).
- 7) Khanna, S., Roy, S., Ryu, H., Bahadduri, P., Swaan, P. W., Ratan, R. R., and Sen, C. K., Molecular basis of vitamin E action. Tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration. J. Biol. Chem., 278, 43508–43515 (2003).
- 8) Inokuchi, H., Hirokane, H., Tsuzuki, T., Nakagawa, K., Igarashi, M., and Miyazawa, T., Anti-angiogenic activity of tocotrienol. Biosci. Biotechnol. Biochem., 67, 1623–1627 (2003).
- 9) Miyazawa, T., Tsuzuki, T., Nakagawa, K., and Igarashi, M., Antiangiogenic potency of vitamin E. Ann. NY Acad. Sci., 1031, 401–404 (2004).
- 10) Hayes, K. C., Pronczuk, A., and Liang, J. S., Differences in the plasma transport and tissue concentrations of tocopherols and tocotrienols: observations in humans and hamsters. Proc. Soc. Exp. Biol. Med., 202, 353–359 (1993).
- 11) Podda, M., Weber, C., Traber, M., and Packer, L., Simultaneous determination of tissue tocopherols, tocotrienols, ubiquinols, and ubiquinones. J. Lipid Res., 37, 893–901 (1996).
- 12) Ikeda, S., Toyoshima, K., and Yamashita, K., Dietary sesame seeds elevate α- and γ-tocotrienol concentrations in skin and adipose tissue of rats fed the tocotrienol-rich fraction extracted from palm oil. J. Nutr., 131, 2892–2897 (2001).
- 13) Qureshi, A. A., Sami, S. A., Salser, W. A., and Khan, F. A., Dose-dependent suppression of serum cholesterol by tocotrienol-rich fraction (TRF25) of rice bran in hypercholesterolemic humans. Atherosclerosis, 161, 199–207 (2002).
- 14) Iqbal, J., Minhajuddin, M., and Beg, Z. H., Suppression of diethylnitrosamine and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats by tocotrienol-rich fraction isolated from rice bran oil. Eur. J. Cancer Prev., 13, 515–520 (2004).
- 15) Kanaya, Y., Doi, T., Sasaki, H., Fujita, A., Matsuno, S., Okamoto, K., Nakano, Y., Tsujiwaki, S., Furuta, H., Nishi, M., Tsuno, T., Taniguchi, H., and Nanjo, K., Rice bran extract prevents the elevation of plasma peroxylipid in KKAy diabetic mice. Diabetes Res. Clin. Pract., 66, S157–S160 (2004).
- 16) Minhajuddin, M., Beg, Z. H., and Iqbal, J., Hypolipidemic and antioxidant properties of tocotrienol rich fraction isolated from rice bran oil in experimentally induced hyperlipidemic rats. Food Chem. Toxicol., 43, 747–753 (2005).
- 17) Hathcock, J. N., Azzi, A., Blumberg, J., Bray, T., Dickinson, A., Frei, B., Jialal, I., Johnston, C. S., Kelly, F. J., Kraemer, K., Packer, L., Parthasarathy, S., Sies, H., and Traber, M. G., Vitamins E and C are safe across a broad range of intakes. Am. J. Clin. Nutr., 81, 736–745 (2005).
- 18) Kamal-Eldin, A., Görgen, S., Pettersson, J., and Lampi, A., Normal-phase high-performance liquid chromatography of tocopherols and tocotrienols. Comparison of different chromatographic columns. J. Chromatogr. A, 881, 217–227 (2000).
- 19) Tsuzuki, T., Igarashi, M., Komai, M., and Miyazawa, T., A metabolic conversion of 9,11,13-eleostearic acid (18:3) to 9,11-conjugated linoleic acid (18:2) in the rat. J. Nutr. Sci. Vitaminol., 49, 195–200 (2003).
- 20) Tsuzuki, T., Tokuyama, Y., Igarashi, M., and Miyazawa, T., Tumor growth suppression by α-eleostearic acid, a linolenic acid isomer with a conjugated triene system, via lipid peroxidation. Carcinogenesis, 25, 1417–1425 (2004).
- 21) Miyazawa, T., Determination of phospholipid hydroperoxides in human blood plasma by a chemiluminescence-HPLC assay. Free Radic. Biol. Med., 7, 209–217 (1989).
- 22) Ohkawa, H., Ohishi, N., and Yagi, K., Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem., 95, 351–358 (1979).
- 23) Yagi, K., A simple fluorometric assay for lipoperoxide in blood plasma. Biochem. Med., 15, 212–216 (1976).
- 24) Hosomi, A., Arita, M., Sato, Y., Kiyose, C., Ueda, T., Igarashi, O., Arai, H., and Inoue, K., Affinity for α-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs. FEBS Lett., 409, 105–108 (1997).
- 25) Traber, M. G., Burton, G. W., Hughes, L., Ingold, K. U., Hidaka, H., Malloy, M., Kane, J., Hyams, J., and Kayden, H. J., Discrimination between forms of vitamin E by humans with and without genetic abnormalities of lipoprotein metabolism. J. Lipid Res., 33, 1171–1182 (1992).
- 26) Behrens, W. A., and Madere, R., Mechanisms of absorption, transport and tissue uptake of RRR-α-tocopherol and d-γ-Tocopherol in the white rat. J. Nutr., 117, 1562–1569 (1987).
- 27) Ikeda, S., Tohyama, T., Yoshimura, H., Hamamura, K., Abe, K., and Yamashita, K., Dietary α-tocopherol decreases α-tocotrienol but not γ-tocotrienol concentration in rats. J. Nutr., 133, 428–434 (2003).
- 28) Kalsotra, A., Anakk, S., Boehme, C. L., and Strobel, H. W., Sexual dimorphism and tissue specificity in the expression of CYP4F forms in Sprague Dawley rats. Drug Metab. Dispos., 30, 1022–1028 (2002).
- 29) Yoshinari, K., Sato, T., Okino, N., Sugatani, J., and Miwa, M., Expression and induction of cytochromes P450 in rat white adipose tissue. J. Pharmacol. Exp. Ther., 311, 147–154 (2004).
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Distribution of Tocotrienols in Rats Fed a Rice Bran Tocotrienol Concentrate
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