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Bioscience, Biotechnology, and Biochemistry Volume 71, 2007 - Issue 3
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Original Articles

Production of Mouse Embryoid Bodies with Hepatic Differentiation Potential by Stirred Tank Bioreactor

Chih-Hsiu YINDepartment of Chemical Engineering, National Tsing Hua University
,
Wannhsin CHENBiomedical Engineering Research Laboratories, Industrial Technology Research Institute
,
Chang-Chun HSIAOGraduate Institute of Clinical Medical Sciences, Chang Gung University;Liver Transplant Program, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University Colleage of Medicine
,
Chao-Ying KUOBiomedical Engineering Research Laboratories, Industrial Technology Research Institute
,
Chao-Long CHENLiver Transplant Program, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University Colleage of Medicine
&
Wen-Teng WUDepartment of Chemical Engineering, National Cheng Kung University
Pages 728-734 | Received 16 Oct 2006, Accepted 09 Dec 2006, Published online: 22 May 2014

  • 1) Allen, J. W., Hassanein, T., and Bhatia, S. N., Advances in bioartificial liver devices. Hepatology, 34, 447–455 (2001).
  • 2) Strain, A. J., and Neuberger, J. M., A bioartificial liver: state of the art. Science, 295, 1005–1009 (2002).
  • 3) Gupta, S., Gorla, G. R., and Irani, A. N., Hepatocyte transplantation: emerging insights into mechanisms of liver repopulation and their relevance to potential therapies. J. Hepatol., 30, 162–170 (1999).
  • 4) Fox, I. J., and Roy-Chowdhury, J., Hepatocyte transplantation. J. Hepatol., 40, 878–886 (2004).
  • 5) Lavon, N., and Benvenisty, N., Study of hepatocyte differentiation using embryonic stem cells. J. Cell. Biochem., 96, 1193–1202 (2005).
  • 6) Keller, G. M., In vitro differentiation of embryonic stem cells. Curr. Opin. Cell Biol., 7, 862–869 (1995).
  • 7) Desbaillets, I., Ziegler, U., Groscurth, P., and Gassmann, M., Embryoid bodies: an in vitro model of mouse embryogenesis. Exp. Physiol., 85, 645–651 (2000).
  • 8) Dang, S. M., Kyba, M., Perlingeiro, R., Daley, G. Q., and Zandstra, P. W., Efficiency of embryoid body formation and hematopoietic development from embryonic stem cells in different culture systems. Biotechnol. Bioeng., 78, 442–453 (2002).
  • 9) Dang, S. M., Gerecht-Nir, S., Chen, J., Itskovitz-Eldor, J., and Zandstra, P. W., Controlled, scalable embryonic stem cell differentiation culture. Stem Cells, 22, 275–282 (2004).
  • 10) Wartenberg, M., Gunther, J., Hescheler, J., and Sauer, H., The embryoid body as a novel in vitro assay system for antiangiogenic agents. Lab. Invest., 78, 1301–1314 (1998).
  • 11) Magyar, J. P., Nemir, M., Ehler, E., Suter, N., Perriard, J. C., and Eppenberger, H. M., Mass production of embryoid bodies in microbeads. Ann. NY Acad. Sci., 944, 135–143 (2001).
  • 12) Gerecht-Nir, S., Cohen, S., and Itskovitz-Eldor, J., Bioreactor cultivation enhances the efficiency of human embryoid body (hEB) formation and differentiation. Biotechnol. Bioeng., 86, 493–502 (2004).
  • 13) Hamazaki, T., Iiboshi, Y., Oka, M., Papst, P. J., Meacham, A. M., Zon, L. I., and Terada, N., Hepatic maturation in differentiating embryonic stem cells in vitro. FEBS Lett., 497, 15–19 (2001).
  • 14) Chinzei, R., Tanaka, Y., Shimizu-Saito, K., Hara, Y., Kakinuma, S., Watanabe, M., Teramoto, K., Arii, S., Takase, K., Sato, C., Terada, N., and Teraoka, H., Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytes. Hepatology, 36, 22–29 (2002).
  • 15) Asahina, K., Fujimori, H., Shimizu-Saito, K., Kumashiro, Y., Okamura, K., Tanaka, Y., Teramoto, K., Arii, S., and Teraoka, H., Expression of the liver-specific gene Cyp7a1 reveals hepatic differentiation in embryoid bodies derived from mouse embryonic stem cells. Genes Cells, 9, 1297–1308 (2004).
  • 16) Rands, G. F., Size regulation in the mouse embryo. II. The development of half embryos. J. Embryol. Exp. Morphol., 98, 209–217 (1986).
  • 17) Ogawa, S., Tagawa, Y., Kamiyoshi, A., Suzuki, A., Nakayama, J., Hashikura, Y., and Miyagawa, S., Crucial roles of mesodermal cell lineages in a murine embryonic stem cell-derived in vitro liver organogenesis system. Stem Cells, 23, 903–913 (2005).
  • 18) Shirahashi, H., Wu, J., Yamamoto, N., Catana, A., Wege, H., Wager, B., Okita, K., and Zern, M. A., Differentiation of human and mouse embryonic stem cells along a hepatocyte lineage. Cell Transplant., 13, 197–211 (2004).

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