184
Views
9
CrossRef citations to date
0
Altmetric
Original Articles

Enzymatic Synthesis of Dehydroderivatives from Proline-Containing Cyclic Dipeptides and Their Effects toward Cell Division

, , &
Pages 830-833 | Received 17 Nov 2006, Accepted 09 Dec 2006, Published online: 22 May 2014

  • 1) Kanzaki, H., Imura, D., Nitoda, T., and Kawazu, K., Effective production of a dehydro cyclic dipeptide albonoursin with pronuclear fusion inhibitory activity. II. Biosynthetic and bioconversion studies. J. Antibiotics, 53, 58–62 (2000).
  • 2) Kanzaki, H., Imura, D., Nitoda, T., and Kawazu, K., Enzymatic conversion of cyclic dipeptides to dehydro derivatives that inhibit cell division. J. Biosci. Bioeng., 90, 86–89 (2000).
  • 3) Kanzaki, H., Yanagisawa, S., and Nitoda, T., Biosynthetic intermediates of tetradehydro cyclic dipeptide albonoursin produced by Streptomyces albulus KO-23. J. Antibiotics, 53, 1257–1264 (2000).
  • 4) Kanzaki, H., Yanagisawa, S., Kanoh, K., and Nitoda, T., A novel potent cell cycle inhibitor dehydrophenylahistin: enzymatic synthesis and inhibitory activity toward sea urchin embryo. J. Antibiotics, 55, 1042–1047 (2002).
  • 5) Kanzaki, H., Yanagisawa, S., and Nitoda, T., Enzymatic synthesis of dehydro cyclo(His-Phe)s, analogs of the potent cell cycle inhibitor, dehydrophenylahistin, and their inhibitory activities toward cell division. Biosci. Biotechnol. Biochem., 68, 2341–2345 (2004).
  • 6) Kanoh, K., Kohno, S., Katada, J., Takahashi, J., Uno, I., and Hayashi, Y., Synthesis and biological activities of phenylahistin derivatives. Bioorg. Med. Chem., 7, 1451–1457 (1999).
  • 7) Arunrattiyakorn, P., Nitoda, T., and Kanzaki, H., Enzymatic conversion-based method for screening cyclic dipeptide-producing microbes. Peptides, 27, 633–639 (2006).
  • 8) Kanzaki, H., Imura, D., Sashida, R., Kobayashi, A., and Kawazu, K., Effective production of a dehydro cyclic dipeptide albonoursin with pronuclear fusion inhibitory activity. I. Taxonomy and fermentation. J. Antibiotics, 52, 1017–1022 (1999).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.