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Original Articles

Effect of a Growth Protein-Colostrum Fraction on Bone Development in Juvenile Rats

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Pages 1-6 | Received 13 Dec 2006, Accepted 24 Sep 2007, Published online: 22 May 2014

  • 1) Aoe, S., Toba, Y., Yamamura, J., Kawakami, H., Yahiro, M., Kumegawa, M., Itabashi, A., and Takada, Y., Controlled trial of the effects of milk basic protein (MBP) supplementation on bone metabolism in healthy adult women. Biosci. Biotechnol. Biochem., 65, 913–918 (2001).
  • 2) Donovan, S. M., and Odle, J., Growth factors in milk as mediators of infant development. Ann. Rev. Nutr., 14, 147–167 (1994).
  • 3) Rao, P. U., and Belavady, B., Protein fractions in human milk. II. Isolation and characterization of basic protein from human milk and the lytic activity of milk samples. Indian J. Biochem. Biophys., 10, 87–90 (1973).
  • 4) Yamamura, J., Takada, Y., Goto, M., Kumegawa, M., and Aoe, S., High mobility group-like protein in bovine milk stimulates the proliferation of osteoblastic MC3T3-E1 cells. Biochem. Biophys. Res. Commun., 261, 113–117 (1999).
  • 5) Pakkanen, R., and Aalto, J., Growth factors and antimicrobial factors of bovine colostrum. Int. Dairy J., 7, 285–297 (1997).
  • 6) Takada, Y., Aoe, S., and Kumegawa, M., Whey protein stimulated the proliferation and differentiation of osteoblastic MC3T3-E1 cells. Biochem. Biophys. Res. Commun., 223, 445–449 (1996).
  • 7) Toba, Y., Takada, Y., Matsuoka, Y., Morita, Y., Motouri, M., Hirai, T., Suguri, T., Aoe, S., Kawakami, H., Kumegawa, M., Takeuchi, A., and Itabashi, A., Milk basic protein promotes bone formation and suppresses bone resorption in healthy adult men. Biosci. Biotechnol. Biochem., 65, 1353–1357 (2001).
  • 8) Manolagas, S. C., Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr. Rev., 21, 115–137 (2000).
  • 9) Rosen, C. J., and Pollak, M., Circulating IGF-I: new perspectives for a new century. Trends Endocrinol. Metab., 10, 136–141 (1999).
  • 10) Yang, L., and Grey, V., Pediatric reference intervals for bone makers. Clin. Biochem., 39, 561–568 (2006).
  • 11) Garnero, P., and Delmas, P. D., Bone markers. Bailliere’s Clin. Rheumatol., 11, 517–537 (1997).
  • 12) Simmen, F. A., Cera, K. R., and Mahan, D. C., Stimulation by colostrum or mature milk of gastrointestinal tissue development in newborn pigs. J. Anim. Sci., 68, 3596–3603 (1990).
  • 13) Berseth, C. L., Lichtenberger, L. M., and Morriss, F. H., Jr., Comparison of the gastrointestinal growth-promoting effects of rat colostrum and mature milk in newborn rats in vivo. Am. J. Clin. Nutr., 37, 52–60 (1983).
  • 14) Cheang, B., and Zydney, A. L., Separation of alpha-lactalbumin and beta-lactoglobulin using membrane ultrafiltration. Biotechnol. Bioeng., 83, 201–209 (2003).
  • 15) Leem, K. H., Kim, M. G., Kim, H. M., Kim, M., Lee, Y. J., and Kim, H. K., Effects of egg yolk proteins on the longitudinal bone growth of adolescent male rats. Biosci. Biotechnol. Biochem., 68, 2388–2390 (2004).
  • 16) Khosla, S., and Kleerekoper, M., Biochemical markers of bone turnover. In “Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism,” ed. Favus, M. J., Lippincott Williams and Wilkins, Philadelphia, pp. 128–134 (1999).
  • 17) Bowles, S. A., Kurdy, N., Davis, A. M., France, M. W., and Marsh, D. R., Serum osteocalcin, total and bone-specific alkaline phosphatase following isolated tibial shaft fracture. Ann. Clin. Biochem., 33, 196–200 (1996).
  • 18) Committee on Animal Nutrition: National Research Council, Chapter 2, Nutrient requirements of the laboratory rat. In “Nutrient Requirements of Laboratory Animals,” National Academy of Sciences, Washington, pp. 11–79 (1995).
  • 19) Nilsson, O., and Baron, J., Fundamental limits on longitudinal bone growth: growth plate senescence and epiphyseal fusion. Trends Endocrinol. Metab., 15, 370–374 (2004).
  • 20) Nilsson, O., and Baron, J., Impact of growth plate senescence on catch-up growth and epiphyseal fusion. Pediatr. Nephrol., 20, 319–322 (2005).
  • 21) Baron, J., Klein, K. O., Yanovski, J. A., Novosad, J. A., Bacher, J. D., Bolander, M. E., and Cutler, G. B., Induction of growth plate cartilage ossification by basic fibroblast growth factor. Endocrinology, 135, 2790–2793 (1994).
  • 22) Toba, Y., Takada, Y., Yamamura, J., Tanaka, M., Matsuoka, Y., Kawakami, H., Itabashi, A., Aoe, S., and Kumegawa, M., Milk basic protein: a novel protective function of milk against osteoporosis. Bone, 27, 403–408 (2000).
  • 23) Aoe, S., Koyama, T., Toba, Y., Itabashi, A., and Takada, Y., A controlled trial of the effect of milk basic protein (MBP) supplementation on bone metabolism in healthy menopausal women. Osteoporos. Int., 16, 123–128 (2005).

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