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Bioscience, Biotechnology, and Biochemistry Volume 62, 1998 - Issue 10
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Original Articles

Effect of Tropine Derivatives, Antimuscarinic Agents, on the Growth of Bombyx mori Larvae

Nozomu TOYOMURALaboratory of Pesticide Chemistry, Department of Agricultural Chemistry, Kyushu University
&
Eiichi KUWANOLaboratory of Pesticide Chemistry, Department of Agricultural Chemistry, Kyushu University
Pages 2046-2048 | Received 08 May 1998, Published online: 22 May 2014

  • 1) Shirai, Y., Iwasaki, T., Matsubara, M., and Aizono, T., The carbachol-induced release of prothoracicotropic hormone from brain-corpus cardiacum-corpus allatum complex of the silkworm, Bombyx mori. J. Insect. Physiol., 40, 469-473 (1994).
  • 2) Aizono, T., Endo, Y., and Shirai, Y., Prothoracicotropic hormone-producing neurosecretory cells in silkworm, Bombyx mori, express a muscarinic acetylcholine receptor. Brain Research, 763, 131-136 (1997).
  • 3) Pauling, P., and Datta, N., Anticholinergic substances: a single consistent conformation. Pro. Natl. Acad. Sci. U.S.A., 77, 708-712 (1980).
  • 4) Leader, H., Gordon, K. R., Baumgold, J., Boyd, L. V., Newman, H. A., Smejkal, M. R., and Chiang, K. P., Muscarinic receptor subtype specificity of (N,N-dialkylamino)alkyl 2-cyclohexyl-2-phenylpropionate: Cylexyphenes (cyclohexyl-substituted aprophene analogues). J. Med. Chem., 35, 1290-1295 (1992).
  • 5) Nordvall, G., Sundquist, S., Johansson, G., Nilvebrant, L., and Hacksell, U., 3-(2-Benzofuranyl)quinuclidin-2-ene derivatives: Novel muscarinic antagonists. J. Med. Chem., 39, 3269-3277 (1996).
  • 6) Asano, S., Kuwano, E., and Eto, M., Anti-juvenile hormone activity of imidazole compound (KK-22) and its diminution by methoprene in the 4th instar silkworm, Bombyx mori L. (Lepidoptera: Bombycidae). Appl. Entomol. Zool., 21, 63-69 (1986).
  • 7) Compound 5: NMR (CDCl3) δ: 1.31-1.34 (2H, m), 1.54 (1H, s), 1.58 (1H, s), 1.70-1.73 (2H, m), 1.94 (3H, s), 2.06-2.08 (1H, m), 2,10-2,12 (1H, m), 2.19 (3H, s), 2.95 (2H, s), 5.07-5.11 (1H, m), 7.22-7.33 (10H, m). Anal. Found: C, 64.38; H, 6.61; N, 2.77%. Calcd. for C27H33NO8 (tartrate): C, 64.92; H, 6.66; N, 2.80%.
  • 8) Caroll, I. F., Abraham, P., Parham, K., Griffith, C. R., Ahmad, A., Richar, M. M., Padilla, N. F., Witkin, M. J., and Chiang, K. P., 6-methyl-6-azabicyclo[3.2.1]octan-3α-ol 2,2-diphenylpropionate (Azaprophen), a highly potent antimuscarinic agent. J. Med. Chem., 30, 805-809 (1987).
  • 9) Gordon, K. R., Padilla, N. F., Moore, E., Doctor, P. B., and Chiang, K. P., Antimuscarinic activity of aprophen. Biochemical Pharmacology, 32, 2979-2981 (1983).
  • 10) Gordon, K. R., Eli, B., Padilla, N. F., Smejkal, M. R., and Chiang, K. P., Distance geometry of a-substituted 2,2-diphenylpropionate antimuscarinics. Molecular Pharmacology, 36, 766-772 (1989).

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