- 1) Boegheim, Jr., J. P. J, an Linde, M., op den Kamp, J. A. F., and Roelofsen, B., The sphingomyelin pools in the outer and inner layer of the human erythrocyte membrane are composed of different molecular species. Biochim. Biophys. Acta, 735, 438-442 (1983).
- 2) Zhang, H., Desai, N. N., Olivera, A., Seki, T., Brooker, G., and Spiegel, S., Sphingosine-1-phosphate, a novel lipid involved in cellular proliferation. J. Cell. Biol., 114, 155-167 (1991).
- 3) Lee, M. J., Van Brocklyn, J. R., Thangada, S., Liu, C. H., Hand, A. R., Menzelee, R., Spiegel, S., and Hla, T., Sphingosine-1-phosphate as a ligand for the G-protein-coupled receptor EDG-1. Science, 279, 1552-1554 (1998).
- 4) a) Hannun, Y. A., Loomis, C. R., Merrill, A., and Bell, R. M., Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J. Biol. Chem., 260, 12604-12609 (1986).
- 4) b) Merrill, Jr., A. H., Nimkar, S., Menaldino, D., Hannun, Y. A., Loomis, C., Bell, R. M., Tyagi, S. R., Lambeth, J. D., Steens, V. L., Hunter, R., and Liotta, D. C., Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds. Biochemistry, 28, 3138-3145 (1989).
- 5) Hannun Y. A., and Obeid, L. M., Ceramide: an intracellular signal for apoptosis. TIBS, 20, 73-77 (1995).
- 6) Desai, N. N., Zhang, H., Olivera, A., Mattie, M. E., and Spiegel, S., Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation. J. Biol. Chem., 267, 23122-23128 (1992).
- 7) Takahata, K., Effect of DHA on cultured neuronal cells: Studies in PC 12 cells. Jap. J. Pharmacology, 67, 29 (1995).
- 8) Mitsutake, S., Kita, K., Okino, N., and Ito, M., [14C] Ceramide synthesis by sphingolipid ceramide N-deacylase: New assay for ceramidase activity detection. Anal. Biochem., 247, 52-57 (1997).
- 9) a) Mori, K. and Funaki, Y., Synthesis of (4E, 8E, 2S, 3R, 2′R)-N-2′-hydroxyhexadecanoyl-9-methyl-4,8-sphingadienine, the ceramide portion of the fruiting-inducing cerebroside in a Basidiomycete schizophyllum commune. Tetrahedron, 41, 2369-2377 (1985).
- 9) b) Kratzer, B., and Schmidt, R. R., Efficient synthesis of sphingosine-1-phosphate, ceramide-1-phosphate, lysosphingosine, and sphingomyelin. Liebigs Ann., 957-963 (1995).
- 9) c) Schmidt, R. R., Bar, T., and Wild, R., Sphingosines-an Oxa-Cope rearrangement route for their synthesis. Synthesis, 868-876 (1995).
Bioscience, Biotechnology, and Biochemistry
Volume 62, 1998 - Issue 10