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Bioscience, Biotechnology, and Biochemistry Volume 64, 2000 - Issue 9
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Original Articles

Gene Regulation in Response to Overexpression of Cytochrome P450 and Proliferation of the Endoplasmic Reticulum in Saccharomyces cerevisiae

Thomas ZIMMERDepartment of Biotechnology, The University of Tokyo;Friedrich Schiller University Jena, Institute of Physiology and Institute of Pathophysiology
,
Atsushi OGURADepartment of Biotechnology, The University of Tokyo
,
Tsuyoshi TAKEWAKADepartment of Biotechnology, The University of Tokyo
,
Rose-Marie ZIMMERDepartment of Biotechnology, The University of Tokyo;Friedrich Schiller University Jena, Institute of Physiology and Institute of Pathophysiology
,
Akinori OHTADepartment of Biotechnology, The University of Tokyo
&
Masamichi TAKAGIDepartment of Biotechnology, The University of Tokyo
Pages 1930-1936 | Received 17 Mar 2000, Accepted 10 May 2000, Published online: 22 May 2014

  • 1) Sitia, R. and Maldolesi, J., Endoplasmic reticulum: A dynamic patchwork of specialized subregions. Mol. Biol. Cell, 3, 1067-1072 (1992).
  • 2) Sandig, G., Kärgel, E., Menzel, R., Vogel, F., Zimmer, T., and Schunck, W. H., Regulation of endoplasmic reticulum biogenesis in response to cytochrome P450 overproduction. Drug Met. Rev., 31, 393-410 (1999).
  • 3) Wright, R., Basson, M., D’Ari, L., and Rine, J., Increased amounts of HMG-CoA reductase induce “karmellae”: a proliferation of stacked membrane pairs surrounding the yeast nucleus. J. Cell Biol., 107, 101-114 (1988).
  • 4) Zimmer, T., Ohkuma, M., Ohta, A., Takagi, M., and Schunck, W.-H., The CYP52 multigene family of Candida maltosa encodes functionally diverse n-alkane-inducible cytochromes P450. Biochem. Biophys. Res. Commun., 224, 784-789 (1996).
  • 5) Zimmer, T., Iida, T., Schunck, W.-H., Yoshida, Y., Ohta, A., and Takagi, M., Relation between evolutionary distance and enzymatic properties among the members of the CYP52A subfamily of Candida maltosa. Biochem. Biophys. Res. Commun., 251, 244-247 (1998).
  • 6) Scheller, U., Zimmer, T., Becher, D., Schauer, F., and Schunck, W.-H., Oxygenation cascade in conversion of n-alkanes to α,ω-dioic acids catalyzed by cytochrome P450 52A3. J. Biol. Chem., 273, 32528-32534 (1998).
  • 7) Schunck, W.-H., Vogel, F., Gross, B., Kärgel, E., Mauersberger, S., Köpke, K., Gengnagel, C., and Müller, H.-G., Comparision of two cytochromes P450 from Candida maltosa: primary structure, substrate specificities and effects of their expression in Saccharomyces cerevisiae on the proliferation of the endoplasmic reticulum. Eur. J. Cell Biol., 55, 336-345 (1991).
  • 8) Vogel, F., Gengnagel, C., Kärgel, E., Müller, H.-G., and Schunck, W.-H., Immunocytochemical localization of alkane-inducible cytochrome P-450 and its NADPH-dependent reductase in the yeast Candida maltosa. Eur. J. Cell Biol., 57, 285-291 (1992).
  • 9) Ohkuma, M., Park, S. M., Zimmer, T., Menzel, R., Vogel, F., Schunck, W.-H., Ohta, A., and Takagi, M., Proliferation of intracellular membrane structures upon homologous overproduction of cytochrome P450 in Candida maltosa. Biochim. Biophys. Acta, 1236, 163-169 (1995).
  • 10) Menzel, R., Vogel, F., Kärgel, E., and Schunck, W.-H., Inducible membranes in yeast: relation to the unfolded-protein-response pathway. Yeast, 13, 1211-1229 (1997).
  • 11) Takewaka, T., Zimmer, T., Hirata, A., Ohta, A., and Takagi, M., Null mutation in IRE1 gene inhibits overproduction of microsomal cytochrome P450Alk1 (CYP52A3) and proliferation of the endoplasmic reticulum in Saccharomyces cerevisiae. J. Biochem., 125, 507-514 (1999).
  • 12) Zimmer T., Vogel, F., Ohta, A., Takagi, M., and Schunck, W.-H., Protein quality—a determinant of the intracellular fate of membrane-bound cytochromes P450 in yeast. DNA Cell Biol., 16, 501-514 (1997).
  • 13) Keszenman-Pereyra, D. and Hieda, K., A colony procedure for transformation of Saccharomyces cerevisiae. Curr. Genet., 13, 21-23 (1988).
  • 14) Frueh, F. W., Zanger, U. M., and Meyer, U. A., Extent and character of phenobarbital-mediated changes in gene expression in the liver. Mol. Pharmacol., 51, 363-369 (1997).
  • 15) Zimmer, T., Ogura, A., Ohta, A., and Takagi, M., Misfolded membrane-bound cytochrome P450 activates KAR2 induction through two distinct mechanisms. J. Biochem., 126, 1080-1089 (1999).
  • . 1983. p. 83- 117.
  • 17) Zimmer, T. and Schunck, W.-H., A deviation from the universal genetic code in Candida maltosa and consequences for heterologous expression of cytochromes P450 52A4 and 52A5 in Saccharomyces cerevisiae. Yeast, 10, 33-41 (1995).
  • 18) Caspary, F., Hartig, A., and Schüller, H.-J., Constitutive and carbon source-responsive promoter elements are involved in the regulated expression of the Saccharomyces cerevisiae malate synthase gene MLS1. Mol. Gen. Genet., 255, 619-627 (1997).
  • 19) Schöler, A. and Schüller, H. J., A carbon source-responsive promoter element necessary for activation of the isocitrate lyase gene ICL1 is common to genes of the gluconeogenic pathway in the yeast S. cerevisiae. Mol. Cell. Biol., 14, 3613-3622 (1994).
  • 20) Rose, M. D., Winston, F., and Hieter, P., Methods in Yeast Genetics. A Laboratory Course Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY (1990).
  • 21) Omura, T. and Sato, R., The carbon monoxide-binding pigment of liver microsomes. J. Biol. Chem., 239, 2370-2385 (1964).
  • 22) Filipits, M., Simon, M. M., Rapatz, W., Hamilton, B., and Ruis, H., A Saccharomyces cerevisiae upstream activating sequence mediates induction of peroxisome proliferation by fatty acids. Gene, 132, 49-55 (1993).
  • . 1992. p. 415- 500.
  • 24) Menzel, R., Kärgel, E., Vogel, F., Böttcher, C., and Schunck, W.-H., Topogenesis of a microsomal cytochrome P450 and induction of endoplasmic reticulum membrane proliferation in Saccharomyces cerevisiae. Arch. Biochem. Biophys., 330, 97-109 (1996).
  • 25) Wiedmann, B., Silver, P., Schunck, W.-H., and Wiedmann, M., Overexpression of the ER-membrane protein P-450 CYP52A3 mimics sec mutant characteristics in Saccharomyces cerevisiae. Biochim. Biophys. Acta, 1153, 267-276 (1993).
  • 26) Scheller, U., Kraft, R., Schröder, K.-L., and Schunck, W.-H., Generation of the soluble and functional cytosolic domain of microsomal cytochrome P450 52A3. J. Biol. Chem., 269, 12779-12783 (1994).
  • 27) Scheller, U., Juretzek, T., and Schunck, W.-H., Generation of the cytosolic domain of microsomal P450 52A3 after high-level expression in Saccharomyces cerevisiae. Methods Enzymol., 272, 65-75 (1996).

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