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Bioscience, Biotechnology, and Biochemistry Volume 64, 2000 - Issue 4
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Original Articles

Steroid 5α-Reductase Inhibitory Activity and Hair Regrowth Effects of an Extract from Boehmeria nipononivea

Kuniyoshi SHIMIZUDepartment of Forest Products, Faculty of Agriculture, Kyushu University
,
Ryuichiro KONDODepartment of Forest Products, Faculty of Agriculture, Kyushu University
,
Kokki SAKAIDepartment of Forest Products, Faculty of Agriculture, Kyushu University
,
Yoshihiro SHOYAMAFacultyof Pharmaceutical Science, Kyushu University
,
Hiroaki SATOKansaiKoso Co. Ltd.
&
Tetsuya UENOKansaiKoso Co. Ltd.
Pages 875-877 | Received 12 Oct 1999, Accepted 16 Dec 1999, Published online: 22 May 2014

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  • 2) Schweikert, H. U., and Wilson, J. D., Regulation of human hair growth by steroid hormones. I. Testosterone metabolism in isolated hairs. J. Clin. Endocrinol. Metab., 38, 811-819 (1974).
  • 3) Imperato-McGinley, J., Guerroro, L., Gautier, T., and Peterson, R. E., Steroid 5α-reductase deficiency in man: an inherited form of male pseudohermaphroditism. Science, 186, 1212-1215 (1974).
  • 4) Rasmusson, G. H., Reynolds, G. F., Steinberg, N. G., Walton, E., Patel, G. F., Liang, T., Cascieri, M. A., Cheung, A. H., Brooks, J. R., and Berman, C., Azasteroids: structure-activity relationships for inhibition of 5α-reductase and of androgen receptor binding. J. Med. Chem., 29, 2298-2315 (1986).
  • 5) McConnell, J. D., Wilson, J. D., George, F. W., Geller, J., Pappas, F., and Stoner, E., Finasteride, an inhibitor of 5α-reductase, suppresses prostatic dihydrotestosterone in men with benign prostatic hyperplasia. J. Clin. Endocrinol. Metab., 74, 505-508 (1992).
  • 6) Rhodes, L., Harper, J., Uno, H., Gaito, G., Audette-arruda, J., Kurata, S., Berman, C., Primka, R., and Pikounis, B., The effects of finasteride (Proscar) on hair growth, hair cycle stage, and serum testosterone and dihydrotestosterone in adult male and female stumptail macaques (Macaca arctoides). J. Clin. Endocrinol. Metab., 79, 991-996 (1994).
  • 7) Shimizu, K., Fukuda, M., Kondo, R., and Sakai, K., The 5α-reductase inhibitory components from heartwood of Artocarpus incisus: Structure-activity investigations. Planta Med., 66, 16-19 (2000).
  • 8) Liang, T., and Liao, S., Inhibition of steroid 5α-reductase by specific aliphatic unsaturated fatty acids. Biochem. J., 285, 557-562 (1992).

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