- 1) Swarts, M. N., Hospital-acquired infections: Diseases with increasingly limited therapies. Proc. Natl. Acad. Sci. USA, 91, 2420-2427 (1994).
- 2) Barrett, J. F. and Hoch, J. A., Antibacterial agents that inhibit two-component signal transduction system. Proc. Natl. Acad. Sci. USA, 95, 5317-5322 (1998).
- 3) Egger, L. A., Park, H., and Inouye, M., Signal transduction via the histidyl-aspartyl phosphorelay. Genes Cells, 2, 167-184 (1997).
- 4) Haldiman, A., Fisher, S. L., Daniels, L. L., Walsh, C. T., and Wanner, B. L., Transcriptional regulation of the Enterococcus faecium BM4147 vancomycin resistance gene cluster by the VanS-VanR two-component regulatory system in Escherichia coli K-12. J. Bacteriol., 179, 5903-5913 (1997).
- 5) Novak, R., Henrlques, B., Charpentler, E., Normark, S., and Tuomanen, E., Emergence of vancomycin tolerance in Streptococcus pneumoniae. Nature, 399, 590-593 (1999).
- 6) Hecht, G. B., Lane, T., Ohta, N., Sommer, J., and Newton, A., An essential single domain response regulator required for normal cell division and differentiation in Caulobacter crescentus. EMBO J., 14, 3915-3924 (1995).
- 7) Quon, K. C., Marczynski, G. T., and Shapiro, L., Cell cycle by an essential bacterial two-component signal transduction protein. Cell, 84, 83-93 (1996).
- 8) Fabret, C. and Hoch, J. A., A two-component signal transduction system essential for growth of Bacillus subtilis: implications for anti-infective therapy. J. Bacteriol., 180, 6375-6383 (1998).
- 9) Martin, P. K., Li, T., Sun, D., Biek, D. P., and Schmid, M. B., Role in cell permeability of an essential two-component system in Staphylococcus aureus. J. Bacteriol., 181, 3666-3673 (1999).
- 10) Roychoudhury, S., Zielinski, N. A., Ninfa, A. J., Allen, N. E., Jungheim, L. N., Nicas, T., and Chakrabarty, A. M., Inhibitors of two-component signal transduction systems: Inhibition of alginate gene activation in Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA, 90, 905-969 (1993).
- 11) Kato, A., Tanabe, H., and Utsumi, R., Molecular characterization of the PhoP-PhoQ two-component system in Escherichia coli K-12: identification of extracellular Mg2+-responsive promoters. J. Bacteriol., 181, 5516-5520 (1999).
- 12) Perraud, A. L., Kimmel, B., Weiss, V., and Gross, R., Specificity of the BvgAS and EvgAS phosphorelay is mediated by the C-terminal Hpt domains of the sensor proteins. Molec. Microbiol., 27, 875-887 (1998).
- 13) Utsumi, R., Katayama, S., Taniguchi, M., Horie, T., Ikeda, M., Igaki, S., Nakagawa, H., Miwa, A., Tanabe, H., and Noda, M., Newly indetified genes involved in the signal transduction of Escherichia coli K-12. Gene, 140, 73-77 (1994).
- 14) Barrett, J. F., Goldschmidt, R. M., Lawrence, L. E., Folence, B., Chen, R., Demers, J. P., Johnson, S., Kanojia, R., Fernandez, J., Bernstein, J., Licata, L., Donetz, A., Huang, S., Hlasta, D. J., Macielag, M. J., Ohemeng, K., Frechette, R., Frosco, M. B., Klaubert, D. H., Whiteley, J. M., Wang, L., and Hoch, J. A., Antibacterial agents that inhibit two-component signal tranduction systems. Proc. Natl. Acad. Sci. USA, 95, 5317-5322 (1998).
- 15) Sui, Z., Guan, J., Hlasta, D. J., Macielag, M. J., Foleno, B. D., Goldschmidt, R. M., Loeloff, M. J., Webb, G. C., and Barrett, J. F., SAR studies of diaryltriazoles against bacterial two-component regulatory systems and their antibacterial activities. Bioorga. Med. Chem. Lett., 8, 1929-1934 (1998).
- 16) Hlasta, D. J., Demers, J. P., Foleno, B. D., Fraga-Spano, S. A., Guan, J., Hilliard, J. J., Macielag, M. J., Kohemeng, A. C., Sheppard, M., Sui, Z., Webb, G. C., Weidner-Ells, M. A., Werblood, H., and Barett, J. F., Novel inhibitors of bacterial two-component system with Gram-positive antibacterial activity: Pharmacophore identification based on the screening hit closantel. Bioorga. Med. Chem. Lett., 8, 1923-1928 (1998).
- 17) Tanabe, H., Masuda, T., Yamasaki, K., Katoh, A., Yoshioka, S., and Utsumi, R., Molecular interaction between proteins involved in EvgAS signal transduction of Escherichia coli. Biosci. Biotechnol. Biochem., 62, 78-82 (1998).
- 18) Casadaban, M. J., Transposition and fusion of lac genes to selected promoter in Escherichia coli using bacteriophages lambda and Mu. J. Mol. Biol., 104, 541-555 (1976).
- 19) National Committee for Clinical Laboratory Standards, Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 4th ed. Approved standard. NCCLS Document M7-A4. National Committee for Clinical Laboratory Standards, Vilanova, PA (1997).
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Identification and Characterization of a Potent Antibacterial Agent, NH125 against Drug-resistant Bacteria
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