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Bioscience, Biotechnology, and Biochemistry Volume 65, 2001 - Issue 3
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Original Articles

Inhibition of Telomerase Activity by Fungus Metabolites, CRM646-A and Thielavin B

Ken-ichi TOGASHIAntibiotics Laboratory, RIKEN;Present address: Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo
,
Hack-Ryong KOAntibiotics Laboratory, RIKEN;Cellular Response Modifier Research Unit, Korea Research Institute of Bioscience and Biotechnology
,
Jong-Seog AHNCellular Response Modifier Research Unit, Korea Research Institute of Bioscience and Biotechnology
&
Hiroyuki OSADAAntibiotics Laboratory, RIKEN
Pages 651-653 | Received 23 May 2000, Accepted 25 Oct 2000, Published online: 22 May 2014

  • 1) Kim, N.W., Piatyszek, M.A., Prowse, K.R., Harley, C.B., West, M.D., Ho, P.L.C., Coviello, G.M., Wright, W.E., Weinrich, S.L., and Shay, J.W., Specific association of human telomerase activity with cells and cancer. Science, 266, 2011-2015 (1994).
  • 2) Shay, J.W. and Bacchetti, S., A survey of telomerase activity in human cancer. Eur. J. Cancer, 33, 787-791 (1997).
  • 3) Feng, J., Funk, W.D., Wang, S.S., Weinrich, S.L., Avillon, A.A., Chiu, C.P., Adams, R.R., Chang, E., Allsopp, R.C., Yu, J., Le, S., West, M.D., Harley, C.B., Anderews, W.H., Greider, C.W., and Villeponteau, B., The RNA component of human telomerase. Science, 269, 1236-1241 (1995).
  • 4) Kondo, S., Kondo, Y., Li, G., Silverman, R.H., and Cowell, J.K., Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA. Oncogene, 16, 3323-3330 (1998).
  • 5) Yegorov, Y.E., Chernov, D.N., Akimov, S.S., Bolsheva, N.L., Krayevsky, A.A., and Zelenin, A.V., Reverse transcriptase inhibitors suppress telomerase function and induce senescence-like process in cultured mouse fibroblasts. FEBS Lett., 389, 115-118 (1996).
  • 6) Strahl, C. and Blackburn, E.H., Effect of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines. Mol. Cell. Biol., 16, 53-65 (1996).
  • 7) Togashi, K., Kakeya, H., Morishita, M., Song, Y.-X., and Osada, H., Inhibition of human telomerase activity by alterperylenol. Oncol. Res., 10, 449-453 (1998).
  • 8) Tatematsu, K.-I., Nakayama, J.-I., Danbara, M., Shionoya, S., Sato, H., Omine, M., and Ishikawa, F., A novel quantitative “stretch PCR assay” that detects a dramatic increase in telomerase activity during the progression of myeloid leukemias. Oncogene, 13, 2265-2274 (1996).
  • 9) Kitahara, N., Endo, A., Furuya, K., and Takahashi, S., Thielavin A and B, new inhibitors of prostaglandin biosynthesis produced by Thielavia terricola. J. Antibiot., 34, 1562-1568 (1981).
  • 10) Mani, N., Sanchet, P., Jiang, Z.-D., McNaney, C., DeCenzo, M., Knighti, B., Stankis, M., Kuranda, M., and Rothstein, D.M., Screening systems for detecting inhibitors of cell wall transglycosylation in enterococcus. Cell wall transglycosylation inhibitors in enterococcus. J. Antibiot., 51, 471-479 (1998).
  • 11) Ko, H.R., Kim, B.Y., Oh, W.K., Kang, D.O., Lee, H.S., Koshino, H., Osada, H., Mheen, T.I., and Ahn, J.S., CRM646-A and -B, novel fungal metabolites that inhibit heparinase. J. Antibiot., 53, 211-214 (2000).
  • 12) Naasani, I., Seimiya, H., and Tsuruo, T., Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins. Biochem. Biophys. Res. Commun., 249, 391-396 (1998).

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