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Bioscience, Biotechnology, and Biochemistry Volume 66, 2002 - Issue 4
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Original Articles

Biosynthesis of Vitamin B6 in Rhizobium: In Vitro Synthesis of Pyridoxine from 1-Deoxy-D-xylulose and 4-Hydroxy-L-threonine

Masaaki TAZOEDepartment of Applied Microbiology, Nippon Roche Research CenterKamakura, Kanagawa 247-8530, Japan
,
Keiko ICHIKAWADepartment of Applied Microbiology, Nippon Roche Research CenterKamakura, Kanagawa 247-8530, Japan
&
Tatsuo HOSHINODepartment of Applied Microbiology, Nippon Roche Research CenterKamakura, Kanagawa 247-8530, Japan
Pages 934-936 | Received 24 Dec 2001, Accepted 25 Dec 2001, Published online: 22 May 2014

  • 1) Lam, H.-M. and Winkler, M. E., Metabolic relationships between pyridoxine (vitamin B6) and serine biosynthesis in Escherichia coli K-12. J. Bacteriol., 172, 6518-6528 (1990).
  • 2) Kennedy, I. A., Hill, R. E., Pauloski, R. M., Sayer, B. G., and Spenser, I. D., Biosynthesis of vitamin B6: origin of pyridoxine by the union of two acyclic precursors, 1-deoxy-D-xylulose and 4-hydroxy-L-threonine. J. Am. Chem. Soc., 117, 1661-1662 (1995).
  • 3) Spenser, I. D. and Hill, R. E., The biosynthesis of pyridoxine. Natural Product Reports, 12, 555-565 (1995).
  • 4) Hill, R. E., Himmeldirk, K., Kennedy, I. A., Pauloski, R. M., Sayer, B. G., Wolf, E., and Spenser, I. D., The biogenetic anatomy of vitamin B6. J. Biol. Chem., 271, 30426-30435 (1996).
  • 5) Cane, D. E., Hsiung, Y., Cornish, J. A., Robinson, J. K., and Spenser, I. D., Biosynthesis of vitamin B6: the oxidation of 4-(phosphohydroxy)-L-threonine by PdxA. J. Am. Chem. Soc., 120, 1936-1937 (1998).
  • 6) Laber, B., Maurer, W., Scharf, S., Stepusin, K., and Schmidt, F. S., Vitamin B6 biosynthesis: formation of pyridoxine 5′-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein. FEBS Lett., 449, 45-48 (1999).
  • 7) Cane, D. E., Du, S., Robinson, J. K., Hsiung, Y., and Spenser, I. D., Biosynthesis of vitamin B6: enzymatic conversion of 1-deoxy-D-xylulose-5-phosphate to pyridoxol phosphate. J. Am. Chem. Soc., 121, 7722-7723 (1999).
  • 8) Tazoe, M., Ichikawa, K., and Hoshino, T., Production of vitamin B6 in Rhizobium. Biosci. Biotechnol. Biochem., 63, 1378-1382 (1999).
  • 9) Tazoe, M., Ichikawa, K., and Hoshino, T., Biosynthesis of vitamin B6 in Rhizobium. J. Biol. Chem., 275, 11300-11305 (2000).

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