511
Views
98
CrossRef citations to date
0
Altmetric
Original Articles

Pro-oxidative Properties of Flavonoids in Human Lymphocytes

, , &
Pages 1215-1222 | Received 02 Oct 2002, Accepted 06 Jan 2003, Published online: 22 May 2014

  • 1) McDonald, M. S., Hughes, M., Burn, J., Lean, M. E., Matthews, D., and Crozier, A., Survey of the free and conjugated myricetin and quercetin content of red wines of different geographical origins. J. Agric. Food Chem., 46, 368-375 (1998).
  • 2) Rice-Evens, C. A., Miller, N. J., and Paganga, G., Structure-antioxidant activity relationships of flavonoids and phenolic acid. Free Radic. Biol. Med., 20, 933-956 (1996).
  • 3) Cao, G., Sofic, E., and Prior, R. L., Antioxidant and prooxidant behavior of flavonoids: Structure-activity relationships. Free Radic. Biol. Med., 22, 749-760 (1997).
  • 4) Ahmad, M. S., Fazal, F., Rahman, A., Hadi, S. M., and Parish, J. H., Activities of flavonoids for cleavage of DNA induced by dietary flavonoids in the presence of Cu (II): Correlation with generation of active oxygen species. Carinogenesis, 13, 605-608 (1992).
  • 5) Sahu, S. C., and Gray, G. C., Kaempferol-induced nuclear DNA damage and lipid peroxidation. Cancer Lett., 85, 159-164 (1994).
  • 6) Aruoma, O. I., Murcia, A., Bultler, J., and Halliwell, B., Evaluation of the antioxidant and prooxidant actions of gallic acid and its derivatives. J. Agric. Food Chem., 41, 1880-1885 (1993).
  • 7) Pond, A. L., Zamora, J. M., and Wells, M. R., Effect of the bioflavonoid morin on Hep-2 cells. Bull. Environ. Contam. Toxic., 53, 562-569 (1994).
  • 8) Ahmad, M. S., Ainley, K., Parish, J. H., and Hadi, S. M., Free radical-induced fragmentation of proteins by quercetin. Carcinogenesis, 15, 1627-1630 (1994).
  • 9) Rahman, A., Fazal, F., Greensill, J., Ainley, K., Parish, J. H., and Hadi, S. M., Strand scission in DNA induced by dietary flavonoids: role of Cu (I) and oxygen free radicals and biological consequences of scission. Mol. Cell. Biochem., 111, 3-9 (1992).
  • 10) Sahu, S. C., and Gray, G. C., Lipid peroxidation and DNA damage induced by morin and naringenin in isolated rat liver nuclei. Food Chem. Toxic., 35, 443-447 (1997).
  • 11) Yen, G. C., Hung, Y. L., and Hsieh, C. L., Protective effect of extracts of Mesona procumbens Hemsl. on DNA damage in human lymphocytes exposed to hydrogen peroxide and UV irradiation. Food Chem. Toxic., 38, 747-754 (2000).
  • 12) Smith, C., Halliwell, B., and Aruoma, O. I., Protection by albumin against the prooxidant actions of phenolic dietary components. Food Chem. Toxic., 30, 483-489 (1992).
  • 13) Rinkus, S. J., and Taylor, R. T., Analysis of hydrogen peroxide in freshly prepared coffees. Food Chem. Toxic., 28, 323-331 (1990).
  • 14) Ramanathan, A., Das, N. P., and Tan, C. H., Effects of γ-linolenic acid, flavonoids, and vitamins on cytotoxicity and lipid peroxidation. Free Radic. Biol. Med., 16, 43-48 (1994).
  • 15) Racker, E., Glutathione reductase from baker's yeast and beef liver. J. Biol. Chem., 217, 855-865 (1955).
  • 16) Habig, W. H., Pabst, M. J., and Jakoby, W. B., Glutathione S-transferase. J. Biol. Chem., 249, 7130-7139 (1974).
  • 17) Boyne, D., and Ellman, G. L., A methodology for analysis of tissue sulfhydryl components. Anal. Biochem., 46, 639-653 (1972).
  • 18) Aruoma, O. I., Assessment of potential prooxidant and antioxidant actions. J. Am. Oil Chem. Soc., 73, 1617-1625 (1996).
  • 19) Hiramoto, K., Sekiguchi, K., Aso, O., Ayuha, K., Ni-lyama, H., Kato, T., and Kikugawa, K., DNA strand breaks induced through active oxygen radicals by fragrant component 4-hydroxy-2-hydroxymethyl-5-methyl-3(2H)-furanone in Maillard reaction of hexose/amino acid. Food Chem. Toxicol., 33, 803-814 (1995).
  • 20) Duthie, S. J., Collins, A. R., Duthie, G. G., and Dobson, V. L., Quercetin and myricetin protect against hydrogen peroxide-induced DNA damage (strand breaks and oxidized pyrimidines) in human lymphocytes. Mutat. Res., 393, 223-231 (1997).
  • 21) Aruoma, O. I., Free radical, oxidative stress, and antioxidants in human health and disease. J. Am. Oil Chem. Soc., 75, 199-211 (1998).
  • 22) Halliwell, B., and Gutteridge, J. M. C., “Free Radicals in Biology and Medicine”, eds. Halliwell, B., and Gutteridge, J. M. C., Clarendon Press, Oxford (1999).
  • 23) Hsiao, G., Teng, C.-M., Wu, C.-L., and Ko, F.-N., Marchantin H as a natural antioxidant and free radical scavenger. Arch. Biochem. Biophys., 334, 18-26 (1996).
  • 24) Maridonneav, P. I., Braquer, P., and Garay, R. P., Heterogeneous effect of flavonoids on K+ loss and lipid peroxidation induced by oxygen-free radicals in human red cells. Pharmacol. Res. Commun., 18, 61-72 (1986).
  • 25) Saija, A., Scalese, M., Lanza, M., Marzullo, D., Bonina, F., and Castelli, F., Flavonoids as antioxidant agents: importance of their interaction with biomembranes. Free Radic. Biol. Med., 19, 481-486 (1995).
  • 26) Zhou, X. F., Zheng, R. L., and Huang, M., Inhibition of photosensitization of morin on DNA synthesis of ascites hepatoma cells. Chung Kao Yao Li Hsueh Pao, 13, 186-188 (1992).
  • 27) Elliott, A. J., Scheiber, S. A., Thomas, C., and Pardini, R. S., Inhibition of glutathione reductase by flavonoids. Biochem. Pharmacol., 44, 1603-1608 (1992).
  • 28) Tan, K. H., Meyer, D. J., Gillies, N., and Ketterer, B., Detoxification of DNA hydroperoxides by glutathione transferases. Biochem. J., 254, 841-845 (1998).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.