129
Views
1
CrossRef citations to date
0
Altmetric
Original Articles

Antigen Feeding Increases Frequency and Antigen-specific Proliferation Ability of Intraepithelial CD4+ T Cells in αβ T Cell Receptor Transgenic Mice

, , , , , , , & show all
Pages 1223-1229 | Received 08 Oct 2002, Accepted 22 Feb 2003, Published online: 22 May 2014

  • 1) Lefrancois, L., Phenotypic complexity of intraepithelial lymphocytes of the small intestine. J. Immunol., 147, 1746-1751 (1991).
  • 2) Guy-Grand, D., and Vassalli, P., Gut intraepithelial T lymphocytes. Curr. Opin. Immunol., 5, 247-252 (1992).
  • 3) Fujihashi, K., Yamamoto, M., McGhee, J. R., and Kiyono, H., αβ T cell receptor-positive intraepithelial lymphocytes with CD4+, CD8- and CD4+, CD8+ phenotypes from orally immunized mice provide Th2-like function for B cell responses. J. Immunol., 151, 6681-6691 (1993).
  • 4) McDonald, V., Robinson, H. A., Kelly, J. P., and Bancroft, G. J., Immunity to Cryptosporidium muris infection in mice is expressed through gut CD4+ intraepithelial lymphocytes. Infect. Immun., 64, 2556-2562 (1996).
  • 5) Halstensen, T. S., and Brandtzaeg, P., Activated T lymphocytes in the celiac lesion: non-proliferative activation (CD25) of CD4+ α/β cells in the lamina propria but proliferation (Ki-67) of α/β and γ/δ cells in the epithelium. Eur. J. Immunol., 23, 505-510 (1993).
  • 6) Ohtsuka, Y., Yamashiro, Y., Maeda, M., Oguchi, S., Shimizu, T., Nagata, S., Yagita, H., Yabata, K., and Okumura, K., Food antigen activates intraepithelial and lamina propria lymphocytes in food-sensitive enteropathy in mice. Pediatr. Res., 39, 862-866 (1996).
  • 7) Sato, T., Sasahara, T., Nakamura, Y., Osaki, T., Hasegawa, T., Tadakuma, T., Arata, Y., Kumagai, Y., Katsuki, M., and Habu, S., Naive T cells can mediate delayed-type hypersensitivity response in T cell receptor transgenic mice. Eur. J. Immunol., 24, 1512-1516 (1994).
  • 8) Sato, T., Hozumi, K., Kishihara, K., Kametani, Y., Sato, C., Kumagai, Y., Mak, T. W., and Habu, S., Evidence for down-regulation of highly expressed TCR by CD4 and CD45 on non-selected CD4+CD8+ thymocytes. Int. Immunol., 8, 1529-1535 (1996).
  • 9) Fujiura, Y., Kawaguchi, M., Kondo, Y., Obana, S., Yamamoto, H., Nanno, M., and Ishikawa, H., Development of CD8αα+ intestinal intraepithelial T cells in β2-microglobulin- and/or TAP1-deficient mice. J. Immunol., 156, 2710-2715 (1996).
  • 10) American Institute of Nutrition, Report of the American Institute of Nutrition ad hoc Committee on standards for nutritional studies. J. Nutr., 107, 1340-1348 (1977).
  • 11) Yoshida, T., Hachimura, S., and Kaminogawa, S., The oral administration of low-dose antigen induces activation followed by tolerization, while high-dose antigen induces tolerance without activation. Clin. Immunol. Immunopathol., 82, 207-215 (1997).
  • 12) Dillon, S. B., and MacDonald, T. T., Functional characterization of Con A-responsive Lyt2-positive mouse small intestinal intraepithelial lymphocytes. Immunology, 59, 389-396 (1986).
  • 13) Sydora, B. C., Mixter, P. F., Holcombe, H. R., Eghtesady, P., Williams, K., Amaral, M. C., Nel, A., and Kronenberg, M., Intestinal intraepithelial lymphocytes are activated and cytolytic but do not proliferate as well as other T cells in response to mitogenic signals. J. Immunol., 150, 2179-2191 (1993).
  • 14) Bland, P. W., and Warren, L. G., Antigen presentation by epithelial cells of the rat small intestine. II. Selective induction of suppressor T cells. Immunology, 58, 9-14 (1986).
  • 15) Yamamoto, M., Fujihashi, K., Kawabata, K., McGhee, J. R., and Kiyono, H., A mucosal intranet: intestinal epithelial cells down-regulate intraepithelial, but not peripheral, T lymphocytes. J. Immunol., 160, 2188-2196 (1998).
  • 16) Kearney, E. R., Pape, K. A., Loh, D. Y., and Jenkins, M. K., Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity, 1, 327-339 (1994).
  • 17) Kaiserlian, D., Vidal, K., and Revillard, J. P., Murine enterocytes can present soluble antigen to specific class II-restricted CD4+ T cells. Eur. J. Immunol., 19, 1513-1516 (1989).
  • 18) Mayer, L., Yio, X. Y., Panja, A., and Campbell, N., Nonprofessional antigen presentation: new rules and regulations. In “Essentials of Mucosal Immunology”, eds. Kagnoff, M. F., and Kiyono, H., Academic Press, San Diego, CA, pp. 55-59 (1996).
  • 19) Kim, S. K., Reed, D. S., Heath, W. R., Carbone, F., and Lefrancois, L., Activation and migration of CD8 T cells in the intestinal mucosa. J. Immunol., 159, 4295-4306 (1997).
  • 20) Lundin, K. E. A., Scott, H., Hansen, T., Paulsen, G., Halstensen, T. S., Fausa, O., Thorsby, E., and Sollid, L. M., Gliadin-specific, HLA-DQ (α1*0501, β1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients. J. Exp. Med., 178, 187-196 (1993).
  • 21) Van de Wal, Y., Kooy, Y. M. C., Van Veelen, P. A., Peña, S. A., Mearin, L. M., Molberg, Ø., Lundin, K. E. A., Sollid, L. M., Mutis, T., Benckhuijsen, W. E., Drijfhout, J. W., and Koning, F., Small intestinal T cells of celiac disease patients recognize a natural fragment of gliadin. Proc. Natl. Acad. Sci. U.S.A., 95, 10050-10054 (1998).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.