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Bioscience, Biotechnology, and Biochemistry Volume 67, 2003 - Issue 9
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Original Articles

Apoptosis Induction in HL-60 Cells and Inhibition of Topoisomerase II by Triterpene Celastrol

Masahiro NAGASEDepartment of Life Sciences, Faculty of Agriculture, Kagawa University2393 Ikenobe, Miki, Kagawa 761-0795, Japan
,
Jinsei OTODepartment of Life Sciences, Faculty of Agriculture, Kagawa University2393 Ikenobe, Miki, Kagawa 761-0795, Japan
,
Sin SUGIYAMADepartment of Life Sciences, Faculty of Agriculture, Kagawa University2393 Ikenobe, Miki, Kagawa 761-0795, Japan
,
Kouichi YUBEResearch Equipment Center, Kagawa Medical University1750-1 Ikenobe, Miki, Kagawa 761-0793, Japan
,
Yoshihisa TAKAISHIFaculty of Pharmaceutical Sciences, University of Tokushima1-78-1 Shomachi, Tokushima, Tokushima 770-8505, Japan
&
Nobuo SAKATOUnited Graduate School of Agricultural Sciences, Ehime University3-5-7 Tarumi, Matsuyama, Ehime 790-8566, Japan
Pages 1883-1887 | Received 06 Feb 2003, Accepted 16 May 2003, Published online: 22 May 2014

  • 1) Morita, T., Saito, K., Maruno, M., Yang, C.-X., Qin, W.-Z., and Yang, B.-H., Leukotiene D4 antagonists in Tripterygium wilfordii. Natural Medicines, 49, 468-471 (1995).
  • 2) Bruning, R., and Wagner, H., Ubersicht uber die celastraceen-inhaltsstoffe: Chemie, chemotaxonomie, biosythese, pharmakologie. Phytochemistry, 17, 1821-1851 (1978).
  • 3) Sassa, H., Takaishi, Y., and Terada, H., The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria. Biochem. Biophys. Res. Commun., 172, 890-897 (1990).
  • 4) Sassa, H., Kogure, K., Takaishi, Y., and Terada, H., Structural basis of potent antiperoxidation activity of the triterpene celastrol in mitochondria: effect of negative membrane surface charge on lipid peroxidation. Free Radic. Biol. Med., 17, 201-207 (1994).
  • 5) Ngassapa, O., Soejarto, D. D., Pezzuto, J. M., and Farnsworth, N. R., Quinone-methide triterpenes and salaspermic acid from Kokoona ochracea. J. Nat. Prod., 57, 1-8 (1994).
  • 6) Takaishi, Y., Wariishi, N., Tateishi, H., Kawazoe, K., Nakano, K., Ono, Y., Tokuda, H., Nishino, H., and Iwashima, A., Triterpenoid inhibitors of interleukin-1 secretion and tumour-promotion from Tripterygium wilfordii var. regelii. Phytochemistry, 45, 969-974 (1997).
  • 7) Allison, A. C., Cacabelos, R., Lombardi, V. R., Alvarez, X. A., and Vigo, C., Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease. Prog. Neuropsychopharmacol Biol. Psychiatry, 25, 1341-1357 (2001).
  • 8) Jin, H. Z., Hwang, B. Y., Kim, H. S., Lee, J. H., Kim, Y. H., and Lee, J. J., Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-κB activation and NO production. J. Nat. Prod., 65, 89-91 (2002).
  • 9) Long, B. H., Musial, S. T., and Brattain, M. G., Single- and double-strand DNA breakage and repair in human lung adenocarcinoma cells exposed to etoposide and teniposide. Cancer Res., 45, 3106-3112 (1985).
  • 10) Pisha, E., Chai, H., Lee, I. S., Chagwedera, T. E., Farnsworth, N. R., Cordell, G. A., Beecher, C. W., Fong, H. H., Kinghorn, A. D., Brown, D. M., Wani, M. C., Wall, M. E., Hieken, T. J., Gupta, T. K. D., and Pezzuto, J. M., Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. Nat. Med., 1, 1046-1051 (1995).
  • 11) Arguello, F., Alexander, M., Sterry, J. A., Tudor, G., Smith, E. M., Kalavar, N. T., Greene, J. F., Jr., Koss, W., Morgan, C. D., Stinson, S. F., Siford, T. J., Alvord, W. G., Klabansky, R. L., and Sausville, E. A., Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity in vivo against human leukemia and lymphoma xenografts. Blood, 91, 2482-2490 (1998).
  • 12) Islam, Z., Nagase, M., Yoshizawa, T., Yamauchi, K., and Sakato, N., T-2 toxin induces thymic apoptosis in vivo in mice. Toxicol. Appl. Pharmacol., 148, 205-214 (1998).
  • . 1994. p. 29A.
  • 14) Martin, S. J., and Green, D. R., Protease activation during apoptosis: death by a thousand cuts? Cell, 82, 349-352 (1995).
  • 15) Hawkins, R. A., Sangster, K., and Arends, M. J., Apoptotic death of pancreatic cancer cells induced by polyunsaturated fatty acids varies with double bond number and involves an oxidative mechanism. J. Pathol., 185, 61-70 (1998).
  • 16) Ma, Y., Ogino, T., Kawabata, T., Li, J., Eguchi, K., and Okada, S., Cupric nitrilotriacetate-induced apoptosis in HL-60 cells association with lipid peroxidation, release of cytochrome c from mitochondria, and activation of caspase-3. Free Radic. Biol. Med., 27, 227-233 (1999).
  • 17) Chen, Y. J., Shiao, M. S., and Wang, S. Y., The antioxidant caffeic acid phenethyl ester induces apoptosis associated with selective scavenging of hydrogen peroxide in human leukemic HL-60 cells. Anticancer Drugs, 12, 143-149 (2001).

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