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Original Articles

Cytotoxicity and DNA Topoisomerase Inhibitory Activity of Benz[f]indole-4,9-dione Analogs

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Pages 1944-1949 | Received 11 Apr 2003, Accepted 02 Jun 2003, Published online: 22 May 2014

  • 1) Zee-Cheng, R. K., and Cheng, C. C., Structure-activity relationship study of anthraquinones: 1,4-dihydroxy-5,8-bis[[2-(2-hydroxyethoxy)ethyl]amino]-9,10-anthracenedione, an analog of an established antineoplastic agent. J. Pharm. Sci., 71, 708-709 (1982).
  • 2) Zee-Cheng, R. K., Mathew, A. E., Xu, P. L., Northcutt, R. V., and Cheng, C. C., Structural modification study of mitoxantrone (DHAQ). Chloro-substituted mono-and bis[(aminoalkyl)amino]anthraquinones. J. Med. Chem., 30, 1682-1686 (1987).
  • 3) Petersen, S., Gauss, W., Kiehne, H., and Juhling, L., Derivatives of 2-amino-1,4-naphthoquinone as carcinostatic agents. Z. Krebsforsch., 72, 162-175 (1969).
  • 4) Silver, R. F., and Holmes, H. L., Synthesis of some 1,4-naphthoquinones and reaction relating to their use in the study of bacterial growth inhibition. Canadian J. Chem., 46, 1859 (1968).
  • 5) Suh, M. E., and Shin, S. H., Synthesis of benz[f]indole-4,9-dione derivatives via intramolecular cyclization (II). Arch. Pharm. Res., 15, 138-141 (1992).
  • 6) Janos, B., CRC handbook of antibiotic compounds 3, CRC Press, Inc., pp. 229 (1981).
  • 7) Wang, J. C., DNA topoisomerases. Annu. Rev. Biochem., 65, 635-692 (1996).
  • 8) Liu, L. F., DNA topoisomerase poisons as antitumor drugs. Annu. Rev. Biochem., 58, 351-375 (1989).
  • 9) Sinha, B. K., Topoisomerase inhibitors. A review of their therapeutic potential in cancer. Drugs, 49, 11-19 (1995).
  • 10) Lee, S. K., Cui, B., Mehta, R. R., Kinghorn, A. D., and Pezzuto, J. M., Cytostatic mechanism and antitumor potential of novel 1H-cyclopenta[b]benzfuran lignans isolated from Aglaia elliptica. Chemico-Biol. Interact., 115, 215-228 (1998).
  • 11) Perrin, D., van Hille, B., Barret, J.-M., Kruczynski, A., Etievant, C., Imbert, T., and Hill, B. T., F 11782, a novel epipodophylloid non-intercalating dual catalytic inhibitor of topoisomerases I and II with an original mechanism of action. Biochem. Pharmacol., 59, 807-819 (2000).
  • 12) Liu, L. F., DNA topoisomerase poisons as antitumor drugs. Annu. Rev. Biochem., 58, 351-375 (1989).
  • 13) Hsiang, Y. H., Hertzberg, R., Hecht, S., and Liu, L. F., Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J. Biol. Chem., 260, 14873-14878 (1985).
  • 14) Svejstrup, J. Q., Christiansen, K., Gromova, I. I., Andersen, A. H., and Westergaard, O., New technique for uncoupling the cleavage and religation reactions of eukaryotic topoisomerase I. The mode of action of camptothecin at a specific recognition site. J. Mol. Biol., 222, 669-678 (1991).
  • 15) Pommier, Y., Pourquier, P., Fan, Y., and Strumberg, D., Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme. Biochim. Biophys. Acta, 1400, 83-106 (1998).
  • 16) Roca, J., The mechanisms of DNA topoisomerases. Trends Biochem. Sci., 20, 156-160 (1995).

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