Advanced search
Publication Cover
Bioscience, Biotechnology, and Biochemistry Volume 67, 2003 - Issue 9
Journal homepage
251
Views
4
CrossRef citations to date
0
Altmetric
Original Articles

Activin A Induces Phosphorylation of Smad2 but Not Complex Formation of Smad2 with Smad4 in Human Colon Cancer Cell Line HT-29

Pimara PHOLNUKULKITLaboratory of Food Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido UniversitySapporo 060-8589, Japan
,
Kei SONOYAMALaboratory of Food Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido UniversitySapporo 060-8589, Japan
&
Jun KAWABATALaboratory of Food Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido UniversitySapporo 060-8589, Japan
Pages 2042-2044 | Received 23 Apr 2003, Accepted 10 Jun 2003, Published online: 22 May 2014

  • 1) Kingsley, D. M., The TGF-β superfamily: New members, new receptors, and new genetic tests of function in different organisms. Genes Dev., 8, 133-146 (1994).
  • 2) Massagué, J., The transforming growth factor-β family. Annu. Rev. Cell. Biol., 6, 597-641 (1990).
  • 3) Sonoyama, K., Rutatip, S., and Kasai, T., Gene expression of activin, activin receptors, and follistatin in intestinal epithelial cells. Am. J. Physiol., 278, G89-G97 (2000).
  • 4) Massagué, J., TGF-beta signal transduction. Annu. Rev. Biochem., 67, 753-791 (1998).
  • 5) Takagi, Y., Kohmura, H., Futamura, M., Kida, H., Tanemura, H., Shimokawa, K., and Saji, S., Somatic alterations of the DPC4 gene in human colorectal cancers in vivo. Gastroenterology, 111, 1369-1372 (1996).
  • 6) Eppert, K., Scherer, S. W., Ozcelik, H., Pirone, R., Hoodless, P., Kim, H., Tsui, L. C., Bapat, B., Gallinger, S., Andrulis, I. L., Thomsen, G. H., Wrana, J. L., and Attisano, L., MADR2 maps to 18q21 and encodes a TGF-beta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell, 86, 543-552 (1996).
  • 7) Zhu, Y., Richardson, J. A., Parada, L. F., and Graff, J. M., Smad3 mutant mice develop metastatic colorectal cancer. Cell, 94, 703-714 (1998).
  • 8) Sonoyama, K., Pholnukulkit, P., Toyoda, M., Rutatip, S., and Kasai, T., Upregulation of activin A gene by butyrate in human colon cancer cell lines. Am. J. Physiol., 284, G989-G995 (2003).
  • 9) Takaku, K., Oshima, M., Miyoshi, H., Matsui, M., Seldin, M. F., and Taketo, M. M., Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell, 92, 645-656 (1998).
  • 10) Fink, S. P., Mikkola, D., Willson, J. K. V., and Markowitz, S., TGF-β-induced nuclear localization of Smad2 and Smad3 in Smad4 null cancer cell lines. Oncogene, 22, 1317-1323 (2003).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.