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Original Articles

Biosynthesis of Branched-chain Fatty Acid in Bacilli: FabD (malonyl-CoA:ACP transacylase) Is Not Essential for In Vitro Biosynthesis of Branched-chain Fatty Acids

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Pages 2106-2114 | Received 26 Mar 2003, Accepted 07 Jul 2003, Published online: 22 May 2014

  • 1) Magnuson, K., Jackowski, S., Rock, C. O., and Cronan, J. E., Regulation of fatty acid biosynthesis in Escherichia coli. Microbiol. Rev., 57, 522-542 (1993).
  • 2) Rock, C. O., and Cronan, J. E., Escherichia coli as a model for the regulation of dissociable (type II) fatty acid biosynthesis. Biochim. Biopys. Acta, 1302, 1-16 (1996).
  • 3) Kaneda, T., Iso- and anteiso-fatty scids in bacteria: biosynthesis, function and taxonomic significance. Microbiol. Rev., 55, 288-302 (1991).
  • 4) Butterworth, P. H. W., and Bloch, K., Comperative aspects of fatty acid synthesis in Bacillus subtilis and Escherichia coli. Eur. J. Biochem., 12, 496-501 (1970).
  • 5) Choi, K.-H., Heath, R. J., and Rock, C. O., β-Keto-acyl carrier protein synthase III (FabH) is a determining factor in branched-chain fatty acid biosynthesis. J. Bacteriol., 182, 365-370 (2000).
  • 6) Morbidoni, H. R., Mendoza, D., and Cronan, J. E., Bacillus subtilis acyl carrier protein is encoded in a cluster of lipid biosynthesis genes. J. Bacteriol., 178, 4794-4800 (1996).
  • 7) Kaneda, T., Biosynthesis of branched long-chain fatty acids from the related short-chain α-keto acid substrates by a cell-free system of Bacillus subtilis. Can. J. Microbiol., 19, 87-96 (1973).
  • 8) Kawaguchi, A., Yoshimura, T., and Okuda, S., A new method for the preparation of acyl-CoA thioesters. J. Biochem., 89, 337-339 (1981).
  • 9) Ellman, G. L., Tissue sulfhydryl groups. Arch. Biochem. Biophys., 82, 70-77 (1950).
  • 10) Kaneda, T., Biosynthesis of branched chain fatty acids I. Isolation and identification of fatty acids from Bacillus subtilis (ATCC 7059). J. Biol. Chem., 238, 1222-1228 (1963).
  • 11) Heath, R. J., and Rock, C. O., Regulation of malonyl-CoA metabolism by acyl-acyl carrier protein and β-ketoacyl-acyl carrier protein synthases in Escherichia coli. J. Biol. Chem., 270, 15531-15538 (1995).
  • 12) Han, L., Lobo, S., and Reynolds, K. A., Characterization of β-ketoacyl-acyl carrier protein synthase III from Streptomyces glaucescens and its role in initiation of fatty acid biosynthesis. J. Bacteriol., 180, 4481-4486 (1998).
  • . 1982. p. 120- 140.
  • 14) Naik, D. N., and Kaneda, T., Biosynthesis of branched long-chain fatty acids by species of Bacillus: relative activity of three a-keto acid substrates and factors affecting chain length. Can. J. Microbiol., 20, 1701-1708 (1974).
  • 15) Oku, H., and Kaneda, T., Biosynthesis of branched-chain fatty acids in Bacillus subtilis. A decarboxylase is essential for branched-chain fatty acid synthetase. J. Biol. Chem., 263, 18386-18396 (1988).
  • 16) Arimura, N., and Kaneda, T., Type selective inhibition of microbial fatty acid synthases by thiolactomycin. Arch. Microbiol., 160, 158-161 (1993).
  • 17) Summers, R. G., Ali, A., Shen, B., Wessel, W. A., and Hutchinson, C. R., Malonyl-coenzyme A:acyl carrier protein acyltransferase of Streptomyces glaucescens: a possible link between fatty acid and polyketide biosynthesis. Biochemistry, 34, 9389-9402 (1995).
  • 18) Hitchman, T. S., Crosby, J., Byrom, K. J., Cox, R. J., and Simpson, T. J., Catalytic self-acylation of type II polyketide synthase acyl carrier proteins. Chem. Biol., 5, 35-47 (1998).
  • 19) Matharu, A.-L., Cox, R. J., Crosby, J., Byrom, K. J., and Simpson, T. J., MCAT is not required for in vitro polyketide synthesis in a minimal actinorhodin polyketide synthase from Streptomyces coelicolor. Chem. Biol., 5, 699-711 (1998).
  • 20) Zhou, P., Florova, G., and Reynolds, K. A., Polyketide synthase acyl carrier protein (ACP) as a substrate and a catalyst for malonyl ACP biosynthesis. Chem. Biol., 6, 577-584 (1999).

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