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Bioscience, Biotechnology, and Biochemistry Volume 67, 2003 - Issue 12
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Original Articles

Induction of Anti-inflammatory Responses by Dietary Momordica charantia L. (Bitter Gourd)

Mariko MANABEDepartment of Food Science and Nutrition, Faculty of Human Life and Science, Doshisha Women's College of Liberal ArtsKamigyo-ku, Kyoto 602-0893, Japan
,
Ryo TAKENAKADepartment of Food Science and Nutrition, Faculty of Human Life and Science, Doshisha Women's College of Liberal ArtsKamigyo-ku, Kyoto 602-0893, Japan
,
Teruko NAKASADepartment of Food Science and Nutrition, Faculty of Human Life and Science, Doshisha Women's College of Liberal ArtsKamigyo-ku, Kyoto 602-0893, Japan
&
Osamu OKINAKADepartment of Food Science and Nutrition, Faculty of Human Life and Science, Doshisha Women's College of Liberal ArtsKamigyo-ku, Kyoto 602-0893, Japan
Pages 2512-2517 | Received 14 May 2003, Accepted 26 Aug 2003, Published online: 22 May 2014

  • 1) Sakaguchi, S., Regulatory T cells: key controllers of immunologic self-tolerance. Cell, 101, 455-458 (2000).
  • 2) Maloy, K. J., and Powrie, F., Regulatory T cells in the control of immune pathology. Nat. Immunol., 2, 816-822 (2001).
  • 3) Yamazaki, M., and Nishimura, T., Induction of neutrophil accumulation by vegetable juice. Biosci. Biotechnol. Biochem., 56, 150-151 (1992).
  • 4) Kaku, S., Yamada, K., Hassan, N., Watanabe, T., and Sugano, M., Effect of vegetable extracts on immunoglobulin production by mesenteric lymph node lymphocytes of Sprague-Dawley Rats. Biosci. Biotechnol. Biochem., 61, 558-560 (1997).
  • 5) Fuke, Y., Watanabe, Y., Furukawa, T., Takasaki, S., Nanayama, M., Matsuoka, H., and Ueda, H., Effects of cooking methods of cabbage on the production of TNF-α and induction of quinone reductase in Hepa 1c1c7 cells. Food Sci. Technol. Res., 7, 311-314 (2001).
  • 6) Manabe, M., Effects of cooking on the immunomodulatory activity of Japanese white radish. Nihon Chourikagaku Kaishi (in Japanese), 36, 249-254 (2003).
  • 7) Platae, K., and Srinivasan, K., Effect of dietary intake of freeze dried bitter gourd (Momordica charantia) in streptozotocin induced diabetic rats. Nahrung, 39, 262-268 (1995).
  • 8) Miura, T., Itoh, C., Iwamoto, N., Kato, M., Park, S.R., and Suzuki, I., Hypoglycemic activity of the fruit of Momordica charantia in type 2 diabetic mice. J. Nutr. Sci. Vitaminol., 47, 340-344 (2001).
  • 9) Singh, A., Singh, S. P., and Bamezai, R., Momordica charantia (bitter gourd) peel, pulp, seed and whole fruit extract inhibits mouse skin papillomagenisis. Toxicol. Lett., 94, 37-46 (1998).
  • 10) Chiampanichayakul, S., Kataoka, K., Arimochi, H., Thumvijit, S., Kuwahara, T., Nakayama, H., Vinitketkumnuen, U., and Ohnishi, Y., Inhibitory effects of bitter melon (Momordica charantia Linn.) on bacterial mutagenesis and aberrant crypt focus formation in the rat colon. J. Med. Invest., 48, 88-96 (2001).
  • 11) Jjiratchariyakul, W., Wiwat, C., Vongsakul, M., Somanabandhu, A., Leelamanit, W., Fujii, I., Suwannaroj, N., and Ebizuka, Y., HIV inhibitor from Thai bitter gourd. Planta Med., 67, 350-353 (2001).
  • 12) Etou, S., Iwashita, K., Takei, T., Yamaki, K., Shinohara, K., and Kobayashi, M., Bitter gourd induces apoptosis in cancer cell lines. Nippon Shokuhin Kagaku Kaishi (in Japanese), 49, 250-256 (2002).
  • 13) Pinto, M., Robine-Leon, S., Appay, M. D., Keinger, M., Triadou, N., Dussulx, E., Lacrois, B., Simon-Assmann, P., Haffen, K., Fogh, J., and Zweibaum, A., Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture. Biol. Cell, 47, 323-330 (1983).
  • 14) Kanzato, H., Manabe, M., and Shimizu, M., An in vitro approach to the evaluation of cross talk between intestinal epithelium and macrophages. Biosci. Biotechnol. Biochem., 65, 449-451 (2001).
  • 15) Glahn, P. R., Lee, A. O., Yeung, A., Goldman, I. M., and Miller, D., Caco-2 cell ferritin formation predicts nonradiolabeled food iron availability in an in vitro digestion/Caco-2 cell culture model. J. Nutr., 128, 1555-1561 (1998).
  • 16) Tan, J. T., Dudl, E., LeRoy, E., Murray, R., Sprent, J., Weinberg, K. I., and Surh, C. D., IL-7 is critical for homeostatic proliferation and survival of naïve T cells. Proc. Natl. Acad. Sci. USA, 98, 8732-8737 (2001).
  • 17) Mehritra, P. T., Grant, A. J., and Siegel, J. P., Synergistic effects of IL-7 and IL-12 on human T cell activation. J. Immunol., 154, 5093-5102 (1995).
  • 18) Komschlies, K. L., Gregorio, T. A., Gruys, M. E., Back, T. C., Faltynel, C. R., and Wiltrout, R. H., Administration of recombinant human IL-7 to mice alters the composition of B-lineage cells and T cell subsets, enhances T cell function, and induces regression of established metastases. J. Immunol., 152, 5776-5784 (1994).
  • 19) Geiselhart, L. A., Humphries, C. A., Gregorio, T. A., Mou, S., Subleski, J., and Konschlies, K. L., IL-7 administration alters the CD4:CD8 ratio, increases T cell numbers, and increases T cell function in the absence of activation. J. Immunol., 166, 3019-3027 (2001).
  • 20) Yuan, D., Koh, C. Y., and Wilder, J. A., Interaction between B lymphocytes and NK cells. FASEB, 8, 1012-1018 (1994).
  • 21) Cai, G., Kastelein, R. A., and Hunter, C. A., IL-10 enhances NK cell proliferaton, cytotoxicity and production of IFN-γ when combined with IL-18. Eur. J. Immunol., 29, 2658-2665 (1999).
  • 22) Ohtsuka, K., Gray, J. D., Stimmler, M. M., Toro, B., and Horwitz, D. A., Decreased production of TGF-β by lymphocytes from patients with systemic lupus erythematosus. J. Immunol., 160, 2539-2545 (1998).
  • 23) Blanca, I. R., Bere, E. W., Young, H. A., and Ortaldo, R., Human B cell activation by autologous NK cells is regulated by CD40-CD40 ligand interaction: role of memory B cells and CD5+ B cells. J. Immunol., 167, 6132-6139 (2001).
  • 24) Llorente, L., Zou, W., Levy, Y., Richaud-Patin, Y., Wijdenses, J., Alcocer-Varela, J., Alarcon-Swgovia, B., and Galanaud, P., Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus. J. Exp. Med., 181, 839-844 (1995).
  • 25) Zan, H., Cerutti, A., Dramitinos, P., Schaffer, A., and Casali, P., CD40 engagement triggers switching to IgA1 and IgA2 in human B cells through induction of endogenous TGF-β: Evidence for TGF-β but not IL-10-dependent direct Sμ→Sα and sequential Sμ→Sγ, Sγ→Sα DNA recombination. J. Immunol., 161, 5217-5225 (1998).
  • 26) Shane-McWhorter, L., Biological complementary therapies: A focus on botanical products in diabetes. Diabetes Spectr., 14, 199-208 (2001).

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