Advanced search
Publication Cover
Bioscience, Biotechnology, and Biochemistry Volume 68, 2004 - Issue 4
Journal homepage
141
Views
5
CrossRef citations to date
0
Altmetric
Original Articles

3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole Induces Apoptosis and Necrosis with Activation of Different Caspases in Rat Splenocytes

Takashi HASHIMOTODepartment of Biofunctional Chemistry, Faculty of Agriculture, Kobe University;Division of Life Science, Graduate School of Science and Technology, Kobe University
,
Takashi SANODepartment of Biofunctional Chemistry, Faculty of Agriculture, Kobe University
,
Wakana ITODepartment of Biofunctional Chemistry, Faculty of Agriculture, Kobe University
,
Kazuki KANAZAWADepartment of Biofunctional Chemistry, Faculty of Agriculture, Kobe University;Division of Life Science, Graduate School of Science and Technology, Kobe University
,
Gen-ichi DANNODepartment of Biofunctional Chemistry, Faculty of Agriculture, Kobe University;Division of Life Science, Graduate School of Science and Technology, Kobe University
&
Hitoshi ASHIDADepartment of Biofunctional Chemistry, Faculty of Agriculture, Kobe University;Division of Life Science, Graduate School of Science and Technology, Kobe University
Pages 964-967 | Received 01 Dec 2003, Accepted 20 Jan 2004, Published online: 22 May 2014

  • 1) Wakabayashi, K., Nagao, M., Esumi, H., and Sugimura, T., Food-derived mutagens and carcinogens. Cancer Res., 52, 2092s–2098s (1992).
  • 2) Hashimoto, T., Ashida, H., Sano, T., Furuyashiki, T., Shiotani, B., Kanazawa, K., and Danno, G., 3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) induces apoptosis in rat splenocytes and thymocytes by different mechanisms. Mutat. Res., 457, 57–67 (2000).
  • 3) Hashimoto, T., Ashida, H., Sano, T., Furuyashiki, T., Hatanaka, Y., Minato, K., Mizuno, M., Nomura, K., Kumatori, A., Kanazawa, K., and Danno, G., 3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) induces caspase-dependent apoptosis in mononuclear cells. Biochem. Biophys. Acta, 1539, 44–57 (2001).
  • 4) Ashida, H., Shiotani, B., Adachi, H., Hashimoto, T., Kanazawa, K., and Danno, G., Tryptophan pyrolysis products, Trp-P-1 and Trp-P-2 induce apoptosis in primary cultured rat hepatocyte. Biosci. Biotechnol. Biochem., 62, 2283–2287 (1998).
  • 5) Wyllie, A. H., Kerr, J. F. R., and Currie, A. R., Cell death: the significance of apoptosis. Int. Rev. Cytol., 68, 251–306 (1980).
  • 6) Ochu, E. E., Rothwell, N. J., and Waters, C. M., Caspases mediate 6-hydroxydopamine-induced apoptosis but not necrosis in PC12 cells. J. Neurochem., 70, 2637–2640 (1998).
  • 7) Ueda, S., Nakamura, H., Masutani, H., Sasada, T., Yonehara, S., Takabayashi, A., Yamaoka, Y., and Yodoi, J., Redox regulation of caspase-3(-like) protease activity: regulatory roles of thioredoxin and cytochrome c. J. Immunol., 161, 6689–6695 (1998).
  • 8) Cohen, G. M., Caspases: the executioners of apoptosis. Biochem. J., 326, 1–16 (1997).
  • 9) Wilhelm, S., Wagner, H., and Hacker, G., Activation of caspase-3-like enzymes in non-apoptotic T cells. Eur. J. Immunol., 28, 891–900 (1998).
  • 10) Miossec, C., Dutilleul, V., Fassy, F., and Diu-Hercend, A., Evidence for CPP32 activation in the absence of apoptosis during T lymphocyte stimulation. J. Biol. Chem., 272, 13459–13462 (1997).
  • 11) Mosmann, T., Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods, 65, 55–63 (1983).
  • 12) Ueda, S., Masutani, H., Nakamura, H., Tanaka, T., Ueno, M., and Yodoi, J., Redox control of cell death. Antioxid. Redox Signal., 4, 405–414 (2002).
  • 13) Ashida, H., Kazuzki, K., and Danno, G., Hepatic phosphoglucomutase activity as a marker of oxidative stress induced by pro-oxidative drugs. Biosci. Biotechnol. Biochem., 58, 55–59 (1994).
  • 14) Hampton, M. B., and Orrenius, S., Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis. FEBS Lett., 414, 552–556 (1997).
  • 15) Won, S. J., Park, E. C., Ryu, B. R., Ko, H. W., Sohn, S., Kwon, H. J., and Gwag, B. J., NT-4/5 exacerbates free radical-induced neuronal necrosis in vitro and in vivo. Neurobiol. Dis., 7, 251–259 (2000).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.