- 1) Barry, M., and Bleackley, R. C., Cytotoxic T lymphocytes: all roads lead to death. Nat. Rev. Immunol., 2, 401–409 (2002).
- 2) Russell, J. H., and Ley, T. J., Lymphocyte-mediated cytotoxicity. Annu. Rev. Immunol., 20, 323–370 (2002).
- 3) Metkar, S. S., Wang, B., Aguilar-Santelises, M., Raja, S. M., Uhlin-Hansen, L., Podack, E., Trapani, J. A., and Froelich, C. J., Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation. Immunity, 16, 417–428 (2002).
- 4) Trapani, J. A., and Sutton, V. R., Granzyme B: pro-apoptotic, antiviral and antitumor functions. Curr. Opin. Immunol., 15, 533–543 (2003).
- 5) Lieberman, J., and Fan, Z., Nuclear war: the granzyme A-bomb. Curr. Opin. Immunol., 15, 553–559 (2003).
- 6) Nagata, S., Apoptosis by death factor. Cell, 88, 355–365 (1997).
- 7) Krammer, P. H., CD95’s deadly mission in the immune system. Nature, 407, 789–795 (2000).
- 8) Miyake, Y., Kakeya, H., Kataoka, T., and Osada, H., Epoxycyclohexenone inhibits Fas-mediated apoptosis by blocking activation of pro-caspase-8 in the death-inducing signaling complex. J. Biol. Chem., 278, 11213–11220 (2003).
- 9) Mitsui, T., Miyake, Y., Kakeya, H., Osada, H., and Kataoka, T., ECH, an epoxycyclohexenone derivative that specifically inhibits Fas ligand-dependent apoptosis in CTL-mediated cytotoxicity. J. Immunol., 172, 3428–3436 (2004).
- 10) Kakeya, H., Miyake, Y., Shoji, M., Kishida, S., Hayashi, Y., Kataoka, T., and Osada, H., Novel non-peptide inhibitors targeting death receptor-mediated apoptosis. Bioorg. Med. Chem. Lett., 13, 3743–3746 (2003).
- 11) Staerz, U. D., Kanagawa, O., and Bevan, M. J., Hybrid antibodies can target sites for attack by T cells. Nature, 314, 628–631 (1985).
- 12) Shinohara, N., Huang, Y. Y., and Muroyama, A., Specific suppression of antibody responses by soluble protein-specific, class II-restricted cytolytic T lymphocyte clones. Eur. J. Immunol., 21, 23–27 (1991).
- 13) Hanabuchi, S., Koyanagi, M., Kawasaki, A., Shinohara, N., Matsuzawa, A., Nishimura, Y., Kobayashi, Y., Yonehara, S., Yagita, H., and Okumura, K., Fas and its ligand in a general mechanism of T-cell-mediated cytotoxicity. Proc. Natl. Acad. Sci. U.S.A., 91, 4930–4934 (1994).
- 14) Watanabe, M., Wegmann, D. R., Ochi, A., and Hozumi, N., Antigen presentation by a B-cell line transfected with cloned immunoglobulin heavy- and light-chain genes specific for a defined hapten. Proc. Natl. Acad. Sci. U.S.A., 83, 5247–5251 (1986).
- 15) Kataoka, T., Shinohara, N., Takayama, H., Takaku, K., Kondo, S., Yonehara, S., and Nagai, K., Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. J. Immunol., 156, 3678–3686 (1996).
- 16) Schneider, P., Holler, N., Bodmer, J. L., Hahne, M., Frei, K., Fontana, A., and Tschopp, J., Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity. J. Exp. Med., 187, 1205–1213 (1998).
- 17) Miwa, K., Hashimoto, H., Yatomi, T., Nakamura, N., Nagata, S., and Suda, T., Therapeutic effect of an anti-Fas ligand mAb on lethal graft-versus-host disease. Int. Immunol., 11, 925–931 (1999).
- 18) Takayama, H., Shinohara, N., Kawasaki, A., Someya, Y., Hanaoka, S., Kojima, H., Yagita, H., Okumura, K., and Shinkai, Y., Antigen-specific directional target cell lysis by perforin-negative T lymphocyte clones. Int. Immunol., 3, 1149–1156 (1991).
- 19) Tanaka, M., Suda, T., Haze, K., Nakamura, N., Sato, K., Kimura, F., Motoyoshi, K., Mizuki, M., Tagawa, S., Ohga, S., Hatake, K., Drummond, A. H., and Nagata, S., Fas ligand in human serum. Nat. Med., 2, 317–322 (1996).
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RKTS-33, an Epoxycyclohexenone Derivative That Specifically Inhibits Fas Ligand-Dependent Apoptosis in CTL-Mediated Cytotoxicity
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