133
Views
13
CrossRef citations to date
0
Altmetric
Original Articles

Pradimicin Resistance of Yeast Is Caused by a Mutation of the Putative N-Glycosylation Sites of Osmosensor Protein Sln1

, , , &
Pages 238-241 | Received 01 Sep 2004, Accepted 18 Oct 2004, Published online: 22 May 2014

  • 1) Oki, T., Konishi, M., Tomatsu, K., Tomita, K., Saitoh, K., Tsunakawa, M., Nishio, M., Miyaki, T., and Kawaguchi, H., Pradimicin, a novel class of potent antifungal antibiotics. J. Antibiotics, 41, 1701–1704 (1988).
  • 2) Kakushima, M., Masuyoshi, S., Hirano, M., Shinoda, M., Ohta, A., Kamei, H., and Oki, T., In vitro and in vivo antifungal activities of BMY-28864, a water-soluble pradimicin derivative. Antimicrob. Agents Chemother., 35, 2185–2190 (1991).
  • 3) Sawada, Y., Numata, K., Murakami, T., Tanimichi, H., Yamamoto, S., and Oki, T., Calcium-dependent anticandidal action of pradimicin A. J. Antibiotics, 43, 715–721 (1990).
  • 4) Hiramoto, F., Nomura, N., Furumai, T., Oki, T., and Igarashi, Y., Apoptosis-like cell death of Saccharomyces cerevisiae induced by a mannose-binding antifungal antibiotic, pradimicin. J. Antibiotics, 56, 768–772 (2003).
  • 5) Ueki, T., Numata, K., Sawada, Y., Nakajima, T., Fukagawa, Y., and Oki, T., Studies on the mode of action of antifungal action of pradimicin antibiotics. I. Lectin-mimic binding of BMY-28864 to yeast mannan in the presence of calcium. J. Antibiotics, 46, 149–161 (1993).
  • 6) Hiramoto, F., Nomura, N., Furumai, T., Igarashi, Y., and Oki, T., Pradimicin-resistance of yeast is caused by a point mutation of the histidine-containing phosphotransfer protein YPD1. J. Antibiotics, 56, 1053–1057 (2003).
  • 7) Posas, F., Wurgler-Murphy, S. M., Maeda, T., Witten, E. A., Thai, T. C., and Saito, H., Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 “two-component” osmosensor. Cell, 86, 865–875 (1996).
  • 8) Li, S., Dean, S., Li, Z., Horecka, J., Deschenes, R. J., and Fassler, J. S., The eukaryotic two-component histidine kinase Sln1p regulates OCH1 via the transcription factor, Skn7p. Mol. Biol. Cell, 13, 412–424 (2002).
  • 9) Ostrander, D. B., and Gorman, J. A., The extracellular domain of the Saccharomyces cerevisiae Sln1p membrane osmolarity sensor is necessary for kinase activity. J. Bacteriol., 181, 2527–2534 (1999).
  • 10) Parkinson, J. S., Signal transduction schemes of bacteria. Cell, 73, 857–871 (1993).
  • 11) Lee, J., Godon, C., Lagniel, G., Spector, D., Garin, J., Labarre, J., and Toledano, M. B., Yap1 and Skn7 control two specialized oxidative stress response regulons in yeast. J. Biol. Chem., 274, 16040–16046 (1999).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.