- 1) Laube, B. L., Benedict, G. W., and Dobs, A. S., The lung as an alternative route of delivery for insulin in controlling postprandial glucose levels in patients with diabetes. Chest, 114, 1734–1739 (1998).
- 2) Patton, J. S., Bukar, J., and Nagarajan, S., Inhaled insulin. Adv. Drug Deliv. Rev., 35, 235–247 (1999).
- 3) Pillai, O., and Panchagnula, R., Insulin therapies: past, present and future. Drug Discov. Today, 6, 1056–1061 (2001).
- 4) Liu, F. Y., Shao, Z., Kildsig, D. O., and Mitra, A. K., Pulmonary delivery of free and liposomal insulin. Pharm. Res., 10, 228–232 (1993).
- 5) Edwards, D. A., Hanes, J., Caponetti, G., Hrkach, J., Ben-Jebria, A., Eskew, M. L., Mintzes, J., Deaver, D., Lotan, N., and Langer, R., Large porous particles for pulmonary drug delivery. Science, 276, 1868–1871 (1997).
- 6) Kwon, J. H., and Kim, C. W., Korea Patent 0327597 (Feb. 23, 2002).
- 7) Kwon, J. H., and Kim, C. W., A novel insulin microcrystal preparation using a seed zone method. J. Crystal Growth, 263, 536–543 (2004).
- 8) Kwon, J. H., Lee, B. H., Lee, J. J., and Kim, C. W., Insulin microcrystal suspension as a long-acting formulation for pulmonary delivery. Eur. J. Pharm. Sci., 22, 107–116 (2004).
- 9) Choi, S. H., Kwon, J. H., and Kim, C. W., Microencapsulation of insulin microcrystals. Biosci. Biotechnol. Biochem., 68, 749–752 (2004).
- 10) Hirai, S., Yashiki, T., and Mima, H., Effect of surfactants on the nasal absorption of insulin in rats. Int. J. Pharm., 9, 165–172 (1981).
- 11) Felig, P., Landmark perspective: protamine insulin: Hagedorn’s pioneering contribution to drug delivery in the management of diabetes. J. Am. Med. Assoc., 251, 393–396 (1984).
- 12) Ilouz, R., Kaidanovich, O., Gurwitz, D., and Eldar-Finkelman, H., Inhibition of glycogen synthase kinase-3beta by bivalent zinc ions: insight into the insulin-mimetic action of zinc. Biochem. Biophys. Res. Commun., 295, 102–106 (2002).
- 13) Kojima, Y., Yoshikawa, Y., Ueda, E., Ueda, R., Yamamoto, S., Kumekawa, K., Yanagihara, N., and Sakurai, H., Insulinomimetic zinc(II) complexes with natural production: in vitro evaluation and blood glucose lowering effect in KK-Ay mice with type 2 diabetes mellitus. Chem. Pharm. Bull., 51, 1006–1008 (2003).
- 14) Brange, J., Havelund, S., Hommel, E., Sorensen, E., and Kuhl, C., Neutral insulin solutions physically stabilized by addition of Zn2+. Diabet. Med., 3, 532–536 (1986).
- 15) Schlichtkrull, J., Insulin crystals: chemical and biological studies on insulin crystals and insulin zinc suspensions. Acta Chem. Scand., 10, 1459 (1961).
Full access
Enhanced Hypoglycemic Activity Following Intratracheal Administration of Insulin Microcrystal Suspension with Injection Adjuvant
Reprints and Corporate Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
To request a reprint or corporate permissions for this article, please click on the relevant link below:
Academic Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
Obtain permissions instantly via Rightslink by clicking on the button below:
If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.
Related research
People also read lists articles that other readers of this article have read.
Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.
Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.