- 1) Kim, K. M., Kawada, T., Ishihara, K., Inoue, K., and Fushiki, T., Increase in swimming endurance capacity of mice by capsaicin-induced adrenal catecholamine secretion. Biosci. Biotechnol. Biochem., 61, 1718–1723 (1997).
- 2) Watanabe, T., Kawada, T., Kato, T., Harada, T., and Iwai, K., Effects of capsaicin analogs on adrenal catecholamine secretion in rats. Life Sci., 54, 369–374 (1994).
- 3) Kim, K. M., Kawada, T., Ishihara, K., Inoue, K., and Fushiki, T., Swimming capacity of mice is increased by oral administration of a nonpungent capsaicin analog, stearoyl vanillylamide. J. Nutr., 128, 1978–1983 (1998).
- 4) Yazawa, S., Suetome, N., Okamoto, K., and Namiki, T., Content of capsaicinoids and capsaicinoid-like substances in fruit of pepper (Capsicum annuum L.) hybrids made with “CH-19 Sweet” as a parent. J. Jpn. Soc. Hortic. Sci., 58, 601–607 (1989).
- 5) Kobata, K., Toda, T., Yazawa, S., Iwai, K., and Watanabe, T., Novel capsaicinoid-like substances, capsiate and dihydrocapsiate, from the fruits of a nonpungent cultivar, CH-19 Sweet, of pepper (Capsicum annuum L.). J. Agric. Food Chem., 46, 1695–1697 (1998).
- 6) Ohnuki, K., Haramizu, S., Watanabe, T., Yazawa, S., and Fushiki, T., CH-19 sweet, nonpungent cultivar of red pepper, increased body temperature in mice with vanilloid receptors stimulation by capsiate. J. Nutr. Sci. Vitaminol., 47, 295–298 (2001).
- 7) Ohnuki, K., Haramizu, S., Oki, K., Watanabe, T., Yazawa, S., and Fushiki, T., Administration of capsiate, a non-pungent capsaicin analog, promotes energy metabolism and suppresses body fat accumulation in mice. Biosci. Biotechnol. Biochem., 65, 2735–2740 (2001).
- 8) Mizunoya, W., Oyaizu, S., Ishihara, K., and Fushiki, T., Protocol for measuring the endurance capacity of mice in an adjustable-current swimming pool. Biosci. Biotechnol. Biochem., 66, 1133–1136 (2002).
- 9) Kim, K. M., Kawada, T., Ishihara, K., Inoue, K., and Fushiki, T., Inhibition by a capsaicin antagonist (capsazepine) of capsaicin-induced swimming capacity increase in mice. Biosci. Biotechnol. Biochem., 62, 2444–2445 (1998).
- 10) Ishihara, K., Oyaizu, S., Onuki, K., Lim, K., and Fushiki, T., Chronic (−)-hydroxycitrate administration spares carbohydrate utilization and promotes lipid oxidation during exercise in mice. J. Nutr., 130, 2990–2995 (2000).
- 11) Matsumoto, K., Ishihara, K., Tanaka, K., Inoue, K., and Fushiki, T., An adjustable-current swimming pool for the evaluation of endurance capacity of mice. J. Appl. Physiol., 81, 1843–1849 (1996).
- 12) Passonneau, J. V., and Lauderdale, V. R., A comparison of three methods of glycogen measurement in tissues. Anal. Biochem., 60, 405–412 (1974).
- 13) Coyle, E. F., Substrate utilization during exercise in active people. Am. J. Clin. Nutr., 61, 968S–979S (1995).
- 14) Bergstrom, J., Hermansen, L., Hultman, E., and Saltin, B., Diet, muscle glycogen and physical performance. Acta Physiol. Scand., 71, 140–150 (1967).
- 15) Spriet, L. L., MacLean, D. A., Dyck, D. J., Hultman, E., Cederblad, G., and Graham, T. E., Caffeine ingestion and muscle metabolism during prolonged exercise in humans. Am. J. Physiol. Endocrinol. Metab., 262, E891–E898 (1992).
- 16) Chwalbinska-Moneta, J., Robergs, R. A., Costill, D. L., and Fink, W. J., Threshold for muscle lactate accumulation during progressive exercise. J. Appl. Physiol., 66, 2710–2716 (1989).
- 17) Kawada, T., Watanabe, T., Takaishi, T., Tanaka, T., and Iwai, K., Capsaicin-induced beta-adrenergic action on energy metabolism in rats: influence of capsaicin on oxygen consumption, the respiratory quotient, and substrate utilization. Proc. Soc. Exp. Biol. Med., 183, 250–256 (1986).
- 18) Oh, T. W., and Ohta, F., Dose-dependent effect of capsaicin on endurance capacity in rats. Br. J. Nutr., 90, 515–520 (2003).
- 19) Lundholm, L., and Svedmyr, N., Influence of adrenaline on blood flow and metabolism in the human forearm. Acta Physiol. Scand., 65, 344–351 (1965).
- 20) Arnall, D. A., Marker, J. C., Conlee, R. K., and Winder, W. W., Effect of infusing epinephrine on liver and muscle glycogenolysis during exercise in rats. Am. J. Physiol. Endocrinol. Metab., 250, E641–E649 (1986).
- 21) Masuda, Y., Haramizu, S., Oki, K., Ohnuki, K., Watanabe, T., Yazawa, S., Kawada, T., Hashizume, S., and Fushiki, T., Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog. J. Appl. Physiol., 95, 2408–2415 (2003).
- 22) Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., and Julius, D., The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature, 389, 816–824 (1997).
- 23) Minke, B., and Cook, B., TRP channel proteins and signal transduction. Physiol. Rev., 82, 429–472 (2002).
- 24) Caterina, M. J., and Julius, D., The vanilloid receptor: a molecular gateway to the pain pathway. Annu. Rev. Neurosci., 24, 487–517 (2001).
- 25) Tominaga, M., Caterina, M. J., Malmberg, A. B., Rosen, T. A., Gilbert, H., Skinner, K., Raumann, B. E., Basbaum, A. I., and Julius, D., The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron, 21, 531–543 (1998).
- 26) Iida, T., Moriyama, T., Kobata, K., Morita, A., Murayama, N., Hashizume, S., Fushiki, T., Yazawa, S., Watanabe, T., and Tominaga, M., TRPV1 activation and induction of nociceptive response by a non-pungent capsaicin-like compound, capsiate. Neuropharmacology, 44, 958–967 (2003).
- 27) Jancso, G., Kiraly, E., and Jancso-Gabor, A., Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones. Nature, 270, 741–743 (1977).
- 28) Suzuki, T., and Iwai, K., Constituents of red pepper species: chemistry, biochemistry, pharmacology, and food science of the pungent principle of Capsicum species. In “The Alkaloids: Chemistry and Pharmacology,” ed. Brossi, A., Academic Press, Orlando, pp. 227–299 (1984).
- 29) Ohnuki, K., Niwa, S., Maeda, S., Inoue, N., Yazawa, S., and Fushiki, T., CH-19 sweet, a non-pungent cultivar of red pepper, increased body temperature and oxygen consumption in humans. Biosci. Biotechnol. Biochem., 65, 2033–2036 (2001).
Full access
Capsiate, a Nonpungent Capsaicin Analog, Increases Endurance Swimming Capacity of Mice by Stimulation of Vanilloid Receptors
Reprints and Corporate Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
To request a reprint or corporate permissions for this article, please click on the relevant link below:
Academic Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
Obtain permissions instantly via Rightslink by clicking on the button below:
If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.
Related research
People also read lists articles that other readers of this article have read.
Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.
Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.