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Bioscience, Biotechnology, and Biochemistry Volume 70, 2006 - Issue 4
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Original Articles

Antihypertensive Effect of Quercetin in Rats Fed with a High-Fat High-Sucrose Diet

Yukiko YAMAMOTOGraduate School of Human Life Science, Osaka City University
&
Eriko OUEFaculty of Human Life Science, Osaka City University
Pages 933-939 | Received 29 Sep 2005, Accepted 10 Dec 2005, Published online: 22 May 2014

  • 1) Roberts, C. K., Vaziri, N. D., Wang, X. Q., and Barnard, R. J., Enhanced NO inactivation and hypertension induced by a high-fat, refined-carbohydrate diet. Hypertension, 36, 423–429 (2000).
  • 2) Wilde, D. W., Massey, K. D., Walker, G. K., Vollmer, A., and Grekin, R. J., High-fat diet elevates blood pressure and cerebrovascular muscle Ca2+ current. Hypertension, 35, 832–837 (2000).
  • 3) Roberts, C. K., Vaziri, N. D., Ni, Z., and Barnard, R. J., Correction of long-term diet-induced hypertension and nitrotyrosine accumulation by diet modification. Atherosclerosis, 163, 321–327 (2002).
  • 4) Newaz, M. A., Nawal, N. N. A., Rohaizan, N. C. H., Muslim, N., and Capor, A., α-Tocopherol increased nitric oxide synthase activity in blood vessels of spontaneously hypertensive rats. Am. J. Hypertension, 12, 839–844 (1999).
  • 5) Chen, X., Touyz, R. M., Park, J. B., and Schiffrin, E. L., Antioxidant effects of vitamins C and E are associated with altered activation of vascular NADPH oxidase and superoxide dismutase in stroke-prone SHR. Hypertension, 38 (part 2), 606–611 (2001).
  • 6) Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V., Dietary vitamin C supplementation lowers blood pressure in spontaneously hypertensive rats. Mol. Cell Biochem., 218, 97–103 (2001).
  • 7) Ceriello, A., Giugliano, D., Quatraro, A., and Lefebvre, P. J., Anti-oxidants show anti-hypertensive effect in diabetic and hypertensive subjects. Clin. Sci., 81, 739–742 (1991).
  • 8) Galley, H. F., Thornton, J., Howdle, P. D., Walker, B. E., and Webster, N. R., Combination oral antioxidant supplementation reduces blood pressure. Clin. Sci., 92, 361–365 (1997).
  • 9) Roberts, C. K., Barnard, R. J., Sindhu, R. K., Jurczak, M., Ehdaie, A., and Vaziri, N. D., A high-fat, refined-carbohydrate diet induces endothelial dysfunction and oxidant/antioxidant imbalance and depresses NOS protein expression. J. Appl. Physiol., 98, 203–210 (2005).
  • 10) Rodríguez, J. A., Grau, A., Eguinoa, E., Nespereira, B., Pérez-Ilzarbe, M., Arias, R., Belzunce, M. S., Páramo, J. A., and Martínez-Caro, D., Dietary supplementation with vitamins C and E prevents downregulation of endothelial NOS expression in hypercholesterolemia in vivo and in vitro. Atherosclerosis, 165, 33–40 (2002).
  • 11) Ilan, E., Tirosh, O., and Madar, Z., Triacylglycerol-mediated oxidative stress inhibits nitric oxide production in rat isolated hepatocytes. J. Nutr., 135, 2090–2095 (2005).
  • 12) Duate, J., Pérez-Vizcaino, F., Zarzuelo, A., Jiménez, J., and Tamargo, J., Vasodilator effects of quercetin in isolated rat vascular smooth muscle. Eur. J. Pharmacol., 239, 1–7 (1993).
  • 13) Gryglewski, R. J., Korbut, R., Robak, J., and Swies, J., On the mechanism of antithrombotic action of flavonoids. Biochem. Pharmacol., 36, 317–322 (1987).
  • 14) Duarte, J., Pérez-Palencia, F., Vargas, M. A., Ocete, F., Pérez-Vizcaino, F., Zarzuelo, F. A., and Tamargo, J., Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats. Br. J. Pharmacol., 133, 117–124 (2001).
  • 15) Morand, C., Crespy, V., Manach, C., Besson, C., Demigné, C., and Rémésy, C., Plasma metabolites of quercetin and their antioxidant properties. Am. J. Physiol., 275, R212–219 (1998).
  • 16) Manach, C., Morand, C., Crespy, V., Demigné, C., Texier, O., Regerat, F., and Rémésy, C., Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties. FEBS Lett., 426, 331–336 (1998).
  • 17) Duate, J., Galisteo, M., Ocete, M. A., Pérez-Vizcaino, F., Zarzuelo, F., and Tamargo, J., Effects of chronic quercetin treatment on hepatic oxidative status of spontaneously hypertensive rats. Mol. Cell Biochem., 221, 155–160 (2001).
  • 18) Frémont, L., Gozzélino, M. T., Franchi, M. P., and Linard, A., Dietary flavonoids reduce lipid peroxidation in rats fed polyunsaturated or monounsaturated fat diets. J. Nutr., 128, 1494–1502 (1998).
  • 19) Reeves, P. G., Components of the AIN-93 diets as improvements in the AIN-76A diet. J. Nutr., 127, 838S–841S (1997).
  • 20) Williams, J. R., Harrison, T. R., and Grollman, A., A simple method for determining the systolic blood pressure of the un-anesthetized rat. J. Clin. Invest., 18, 373–376 (1939).
  • 21) Ohkawa, H., Ohishi, N., and Yagi, K., Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biolchem., 95, 351–358 (1979).
  • 22) Wu, G., Flynn, N. E., Flynn, S. P., Jolly, C. A., and Davis, P. K., Dietary protein or arginine deficiency impairs constitutive and inducible nitric oxide synthesis by young rats. J. Nutr., 129, 1347–1354 (1999).
  • 23) Bredt, D. S., and Snyder, S. H., Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc. Natl. Acad. Sci. USA, 86, 9030–9033 (1989).
  • 24) Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265–275 (1951).
  • 25) Gebhardt, R., Variable influence of kaempferol and myricetin on in vitro hepatocellular cholesterol biosynthesis. Planta Med., 69, 1071–1074 (2003).
  • 26) Li, B.-H., and Tian, W.-X., Inhibitory effects of flavonoids on animal fatty acid synthase. J. Biochem., 135, 85–91 (2004).
  • 27) Thomson, L., Trujillo, M., Telleri, R., and Radi, R., Kinetics of cytochrome c2+ oxidation by peroxinitrite: implications for superoxide measurements in nitric oxide-producing biological systems. Arch. Biochem. Biophys., 319, 491–497 (1995).
  • 28) d’Uscio, L. V., Milstien, S., Richardson, D., Smith, L., and Katusic, Z. S., Long-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity. Circ. Res., 92, 88–95 (2003).
  • 29) Cosentino, F., and Katsusic, Z. S., Tetrahydrobiopterin and dysfunction of endothelial nitric oxide synthase in coronary arteries. Circulation, 91, 139–144 (1995).
  • 30) Massiera, F., Bloch-Faure, M., Ceiler, D., Murakami, K., Fukamizu, A., Gasc, J. M., Quignard-Boulange, A., Negrel, R., Aihaud, G., Seydoux, J., Meneton, P., and Teboul, M., Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB J., 15, 2727–2729 (2001).
  • 31) Boustany, C. M., Bharadwaj, K., Daugherty, A., Brown, D. R., Randall, D. C., and Cassis, L. A., Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertension. Am. J. Physiol. Regul. Integr. Comp. Physiol., 287, R943–R949 (2004).

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