550
Views
10
CrossRef citations to date
0
Altmetric
Original Articles

Effect of an Excessive Intake of Quercetin on the Vitamin E Level and Antioxidative Enzyme Activities of Mouse Liver under Paraquat-Induced Oxidative Stress

, &
Pages 2569-2572 | Received 09 May 2007, Accepted 20 Jun 2007, Published online: 22 May 2014

  • 1) Arts, I. C. W., and Hollman, C. H., Polyphenols and disease risk in epidemiologic studies. Am. J. Clin. Nutr., 81, 317S-325S (2005).
  • 2) Terao, J., Dietary flavonoids as antioxidants in vivo: conjugated metabolites of (−)epicatechin and quercetin participate in antioxidative defense in blood plasma. J. Med. Invest., 46, 159–168 (1999).
  • 3) Nagata, H., Takekoshi, S., Takagi, T., Honma, T., and Watanabe, K., Antioxidative action of flavonoids, quercetin, by the activation of glutathione peroxidase. Tokai J. Exp. Clin. Med., 24, 1–11 (1999).
  • 4) Bok, S. H., Park, Y. H., Lee, M. K., Jeon, S. M., Jeong, T. S., and Choi, M. S., Quercetin dehydrate and gallate supplements lower plasma and hepatic lipids and change activities of hepatic antioxidant enzymes in high cholesterol fed rats. Int. J. Vitam. Nutr. Res., 72, 161–169 (2002).
  • 5) Alia, M., Mateous, R., Ramos, S., Lecumberri, E., Bravo, L., and Goya, L., Influence of quercetin and rutin on growth and antioxidant defense system of a human hepatoma cell line (HepG2). Eur. J. Nutr., 45, 19–28 (2006).
  • 6) Formica, J. V., and Regelson, W., Review of the biology of quercetin and related bioflavonoids. Fd. Chem. Toxic., 33, 1061–1080 (1995).
  • 7) Skibola, C. F., and Smith, M. T., Potential health impact of excessive flavonoid intake. Free Radic. Biol. Med., 29, 375–383 (2000).
  • 8) Galati, G., and O’Brien, P. J., Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radic. Biol. Med., 37, 287–303 (2004).
  • 9) Guohua, C., Sofic, E., and Prior, R. L., Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships. Free Radic. Biol. Med., 22, 749–760 (1997).
  • 10) Metodiewa, D., Jaiswal, A. K., Cenas, N., Dickancaite, E., and Segura-Aguilar, J., Quinone may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product. Free Radic. Biol. Med., 26, 107–116 (1999).
  • 11) Kawanishi, S., Oikawa, S., and Murata, M., Evaluation for safety of antioxidant chemopreventive agents. Antioxid. Redox Signal., 7, 1728–1739 (2005).
  • 12) Kamada, C., da Silva, E. L., Ohnishi-Kameyama, M., Moon, J.-H., and Terao, J., Attenuation of lipid peroxidation and hyperlipidemia by quercetin glucoside in the aorta of high cholesterol-fed rabbit. Free Radic. Res., 39, 185–194 (2005).
  • 13) Igarashi, K., Kimura, Y., and Takemura, A., Protective effects of dietary cabbage acylated anthocyanins on paraquat-induced oxidative stress in rats. Biosci. Biotechnol. Biochem., 64, 1600–1607 (2000).
  • 14) Kimura, Y., Araki, Y., Takenaka, A., and Igarashi, K., Protective effects of dietary nasunin on paraquat-induced oxidative stress in rats. Biosci. Biotechnol. Biochem., 63, 799–804 (1999).
  • 15) Umegaki, K., Aoshima, M., Hirota, S., Uramoto, H., and Esashi, T., Simulataneous dietary supplementation of sodium cholate and beta-carotene markedly enhances accumulation of beta-carotene in mice. J. Nutr., 125, 3081–3086 (1995).
  • 16) Beauchamp, C., and Fridovich, I., Improved assays and an assay applicable to acrylamide gels. Anal. Biochem., 44, 276–287 (1971).
  • 17) Gunzler, W. A., Steffens, G. J., Grossmann, A., Kim, S. M., Otting, F., Wendel, A., and Flohe, L., The amino acid sequence of bovine glutathione peroxidase. Hoppe-Seyler Z Physiol. Chem., 365, 195–212 (1984).
  • 18) Bando, N., Hayashi, H., Wakamatsu, S., Inakuma, T., Miyoshi, M., Nagao, A., Yamauchi, R., and Terao, J., Participation of singlet oxygen in ultraviolet A-induced lipid peroxidation in mouse skin and its inhibition by dietary β-carotene: an ex vivo study. Free Radic. Biol. Med., 37, 1854–1863 (2004).
  • 19) Molina, M. F., Sanchez-Reus, I., Iglesia, I., and Bendi, J., Quercetin, a flavonoid antioxidant, prevents and protects against ethanol-induced oxidative stress in mouse liver. Biol. Pharm. Bull., 26, 1398–1402 (2003).
  • 20) Dias, A. S., Porawski, M., Alonso, M., Marroni, N., Collado, P. S., and Gonzalez-Gallego, J., Quercetin decreases oxidative stress, NF-κB activation and iNOS overexpression in liver of streptozotocin-induced diabetic rats. J. Nutr., 135, 2299–2304 (2005).
  • 21) Peres, W., Tunon, M. J., Collado, P. S., Herrmann, S., Marroni, N., and Gonzalez-Gallego, J., The flavonoid quercetin ameliorates liver damage in rats with biliary obstruction. J. Hepatol., 33, 742–750 (2000).
  • 22) Choi, E. J., Chee, K.-M., and Lee, B. H., Anti- and prooxidant effects of chronic quercetin administration in rats. Eur. J. Pharamacol., 482, 281–285 (2003).
  • 23) Eberhardt, M. V., and Jeffery, E. H., Perspective: when dietary antioxidants perturb the thiol redox. J. Sci. Food Agric., 86, 1996–1998 (2006).
  • 24) Murota, K., and Terao, J., Antioxidative flavonoid quercetin: implication of its intestinal absorption and metabolism. Arch. Biochem. Biophys., 417, 12–17 (2003).
  • 25) De Boer, V. C. J., Dihal, A. A., van der Woude, H., Arts, I. C. W., Wolffram, S., Alink, G. M., Rietjens, I. M. C. M., Keijer, J., and Hollman, C. H., Tissue distribution of quercetin in rats and pigs. J. Nutr., 135, 1718–1725 (2005).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.