- 1) Fidler, I. J., Gersten, D. M., and Hart, I. R., The biology of cancer invasion and metastasis. Adv. Cancer Res., 28, 149–250 (1978).
- 2) Liotta, L. A., Wewer, U., Rao, N. C., Schiffmann, E., Stracke, M., Guirguis, R., Thorgeirsson, U., Muschel, R., and Sobel, M., Biochemical mechanism of tumor invasion and metastasis. Prog. Clin. Biol. Res., 256, 3–16 (1988).
- 3) Mareel, M. M., Recent aspects of tumor invasiveness. Int. Rev. Exp. Pathol., 22, 65–129 (1980).
- 4) Szatrowski, T. P., and Nathan, C. F., Production of large amount of hydrogen peroxide by human tumor cells. Cancer Res., 51, 794–798 (1991).
- 5) Schubert, R., Erker, L., Barlow, C., Yakushiji, H., Larson, D., Russo, A., Mitchell, J. B., and Wynshaw-Boris, A., Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice. Hum. Mol. Genet., 13, 1793–1802 (2004).
- 6) Kozuki, Y., Miura, Y., and Yagasaki, K., Inhibitory effects of carotenoids on the invasion of rat ascites hepatoma cells in culture. Cancer Lett., 151, 111–115 (2000).
- 7) Kozuki, Y., Miura, Y., and Yagasaki, K., Resveratrol suppresses hepatoma cell invasion independently of its anti-proliferative activity. Cancer Lett., 167, 151–156 (2001).
- 8) Zhang, G., Miura, Y., and Yagasaki, K., Inhibition of hepatoma cell invasion beneath mesothelial-cell monolayer by serum from tea- and related component-treated rats and their modes of action. Cytotechnology, 36, 187–193 (2001).
- 9) Zhang, G., Miura, Y., and Yagasaki, K., Induction of apoptosis and cell cycle arrest in hepatoma cells by in vivo metabolites of teas. Nutr. Cancer, 38, 265–273 (2000).
- 10) Eberhardt, M. V., Lee, C. Y., and Liu, R. H., Antioxidant activity of fresh apples. Nature, 405, 903–904 (2000).
- 11) Lee, K. W., Kim, Y. J., Kim, D. O., Lee, H. J., and Lee, C. Y., Major phenolics in apple and their contribution to the total antioxidant capacity. J. Agric. Food Chem., 51, 6516–6520 (2003).
- 12) Kanda, T., Akiyama, H., Yanagida, A., Tanabe, M., Goda, Y., Toyoda, M., Teshima, R., and Saito, Y., Inhibitory effects of apple polyphenol on induced histamine release from RBL-2H3 cells and rat mast cells. Biosci. Biotechnol. Biochem., 62, 1284–1289 (1998).
- 13) Shoji, T., Masumoto, S., Moriichi, N., Kobori, M., Kanda, T., Shinmoto, H., and Tsushida, T., Procyanidin trimers to pentamers fractionated from apple inhibit melanogenesis in B16 mouse melanoma cells. J. Agric. Food Chem., 53, 6105–6111 (2005).
- 14) Kern, M., Pahlke, G., Balavenkatraman, K. K., Bohmer, F. D., and Marko, D., Apple polyphenols affect protein kinase C activity and the onset of apoptosis in human colon carcinoma cells. J. Agric. Food Chem., 55, 4999–5006 (2007).
- 15) Alsabti, E. A., Serum lipids in hepatoma. Oncology, 36, 11–14 (1979).
- 16) Hirayama, C., Yamanishi, Y., and Irisa, T., Serum cholesterol and squalene in hepatocellular carcinoma. Clin. Chim. Acta, 91, 53–57 (1979).
- 17) Clark, R. W., and Crain, R. C., Characterization of alteration in plasma lipoprotein lipid and apoprotein profiles accompanying hepatoma-induced hyperlipidemia in rats. Cancer Res., 46, 1894–1903 (1986).
- 18) Irikura, T., Takagi, K., Okada, K., and Yagasaki, K., Effect of KCD-232, a new hypolipidemic agent, on serum lipoprotein changes in hepatoma-bearing rats. Lipids, 20, 420–424 (1985).
- 19) Kawasaki, M., Funabiki, R., and Yagasaki, K., Effect of dietary methionine and cystine on lipid metabolism in hepatoma-bearing rats with hyperlipidemia. Lipids, 33, 905–911 (1998).
- 20) Komatsu, W., Miura, Y., and Yagasaki, K., Suppression of hypercholesterolemia in hepatoma-bearing rats by cabbage extract and its component, S-methyl-L-cysteine sulfoxide. Lipids, 33, 499–503 (1998).
- 21) Zhang, G., Miura, Y., and Yagasaki, K., Effects of dietary powdered green tea and theanine on tumor growth and endogeneous hyperlipidemia in hepatoma-bearing rats. Biosci. Biotechnol. Biochem., 66, 711–716 (2002).
- 22) Miura, D., Miura, Y., and Yagasaki, K., Hypolipidemic action of dietary resveratrol, a phytoalexin in grapes and red wine, in hepatoma-bearing rats. Life Sci., 73, 1393–1400 (2003).
- 23) Miura, D., Ito, Y., Mizukuchi, A., Kise, M., Aoto, H., and Yagasaki, K., Hypocholesterolemic action of pre-germinated brown rice in hepatoma-bearing rats. Life Sci., 79, 259–264 (2006).
- 24) Reeves, P. G., Nielsen, F. H., and Fahey, G. C., AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J. Nutr., 123, 1939–1951 (1993).
- 25) Miura, Y., Kozuki, Y., and Yagasaki, K., Potentiation of invasive activity of hepatoma cells by reactive oxygen species is mediated by autocrine loop of hepatocyte growth factor. Biochem. Biophys. Res. Commun., 305, 160–165 (2003).
- 26) Yagasaki, K., Tanabe, T., Ishihara, K., and Funabiki, R., Modulation of the proliferation of cultured hepatoma cells by ureacycle-related amino acids. In “Animal Cell Technology: Basic & Applied Aspects” Vol. 4, eds. Murakami, H., Shirahata, S., and Tachibana, H., Kluwer Academic Publishers, Dordrecht, pp. 257–263 (1992).
- 27) Akedo, H., Shinkai, K., Mukai, M., Mori, Y., Tateishi, R., Tanaka, K., Yamamoto, R., and Morishita, T., Interaction of rat ascites hepatoma cells with cultured mesothelial cell layers: a model for tumor invasion. Cancer Res., 46, 2416–2422 (1986).
- 28) Yamanaka, Y., Tsuji, K., and Ichikawa, T., Stimulation of chenodeoxycholic acid excretion in hyperlipidemic mice by dietary taurine. J. Nutr. Sci. Vitaminol., 32, 287–296 (1986).
- 29) Yagasaki, K., Machida-Takehana, M., and Funabiki, R., Effects of dietary methionine and glycine on serum lipoprotein profiles and fecal steroid excretion in normal and hepatoma-bearing rats. J. Nutr. Sci. Vitaminol., 36, 45–54 (1990).
- 30) Parr, C., and Jiang, W. G., Expression of hepatocyte growth factor/scatter factor, its activator, inhibitors and the c-Met receptor in human cancer cells. Int. J. Oncol., 19, 857–863 (2001).
- 31) Miura, D., Miura, Y., and Yagasaki, K., Resveratrol inhibits hepatoma cell invasion by suppressing gene expression of hepatocyte growth factor via its reactive oxygen species-scavenging property. Clin. Exp. Metastasis, 21, 445–451 (2004).
- 32) Yagasaki, K., Okauchi, R., and Miura, Y., Bioavailability and inhibitory actions of trigonelline, chlorogenic acid and related compounds against hepatoma cell invasion in culture and their modes of actions. In “Animal Cell Technology: Basic & Applied Aspects” Vol. 12, eds. Shirahata, S., Teruya, K., and Katakura, Y., Kluwer Academic Publishers, Dordrecht, pp. 421–425 (2002).
- 33) Shoji, T., Masumoto, S., Moriichi, N., Akiyama, H., Kanda, T., Ohtake, Y., and Goda, Y., Apple procyanidin oligomers absorption in rats after oral administration: analysis of procyanidins in plasma using the porter method and high-performance liquid chromatography/tandem mass spectrometry. J. Agric. Food Chem., 54, 884–892 (2006).
- 34) Gosse, F., Guyot, S., Roussi, S., Lobstein, A., Fischer, B., Seiler, N., and Raul, F., Chemopreventive properties of apple procyanidins on human colon cancer-derived metastatic SW620 cells and in a rat model of colon carcinogenesis. Carcinogenesis, 26, 1291–1295 (2005).
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Effect of Apple Polyphenol Extract on Hepatoma Proliferation and Invasion in Culture and on Tumor Growth, Metastasis, and Abnormal Lipoprotein Profiles in Hepatoma-Bearing Rats
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