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Original Articles

Urinary Excretory Ratio of Anthranilic Acid/Kynurenic Acid as an Index of the Tolerable Amount of Tryptophan

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Pages 1667-1672 | Received 03 Oct 2007, Accepted 25 Feb 2008, Published online: 22 May 2014

  • 1) Wurtman, R. J., Nutrition that modify brain function. Sci. Am., 50, 246–249 (1982).
  • 2) Fernstorm, J. D., Can nutrient supplements modify brain function. Am. J. Clin. Nutr., 71 (Suppl), 1669S–1673S (2000).
  • 3) Cardinali, D. P., Melatonin. A mammalian pineal hormone. Endocr. Rev., 2, 327–346 (1981).
  • 4) Matsueda, S., and Niiyama, Y., The effect of excess amino acids on maintenance of pregnancy and fetal growth in rat. J. Nutr. Sci. Vitaminol., 28, 557–573 (1982).
  • 5) Gullino, P., Winitz, M., Birnbaum, S. M., Cornfield, J., Clyde, M., Jesse, O., and Greenstein, P., Studies on the metabolism of amino acids and related compounds in vivo. I. Toxicity of essential amino acids individually and in mixtures, and the protective effect of L-arginine. Arch. Biochem. Biophys., 64, 319–332 (1956).
  • 6) Pakes, G. E., L-tryptophan in psychiatric practice. Drug Intel. Clin. Pharm., 13, 391–396 (1979).
  • 7) Shibata, K., Kawada, T., and Iwai, K., Simultaneous micro-determination of nicotinamide and its major metabolites, N 1-methyl-2-pyridone-5-carboxamide and N 1-methyl-3-pyridone-4-carboxamide, by high-performance liquid chromatography. J. Chromatogr., 424, 23–28 (1988).
  • 8) Pullman, M. E., and Colowick, S. P., Preparation of 2- and 6-pyridones of N1-methylnicotinamide. J. Biol. Chem., 206, 121–127 (1954).
  • 9) Shibata, K., Ultramicro-determination of N 1-methylnicotinamide in urine by high-performance liquid chromatography. Vitamins, 61, 599–604 (1987).
  • 10) Shibata, K., and Onodera, M., Measurement of 3-hydroxyanthranilic acid and anthranilic acid in urine by high-performance liquid chromatography. Agric. Biol. Chem., 55, 143–148 (1991).
  • 11) Shibata, K., Fluorimetric micro-determination of kynurenic acid, as endogenous blocker of neurotoxicity, by high-performance liquid chromatography. J. Chromatogr., 430, 376–380 (1988).
  • 12) Shibata, K., and Onodera, M., Simultaneous high-performance liquid chromatographic measurement of xanthurenic acid and 3-hydroxyanthranilic acid in urine. Biosci. Biotechnol. Biochem., 56, 974 (1992).
  • 13) Mawatari, K., Oshida, K., Iinuma, F., and Watanabe, W., Determination of quinolinic acid in human urine by liquid chromatography with fluorimetric detection. Anal. Clin. Acta, 302, 179–183 (1995).
  • 14) Hajak, G., Huether, G., Blanke, J., Blömer, M., Freyer, C., Poeggeler, B., Reimer, A., Rodenbeck, A., Schulz-Varszegi, M., and Rüther, E., The influence of intravenous L-tryptophan on plasma melatonin and sleep in men. Pharmacophychiatry, 24, 17–20 (1991).
  • 15) Ouichou, A., and Pévet, P., Implication of tryptophan in the stimulatory effect of delta-sleep-inducing peptide on indole secretion form perfused rat pineal glands. Biol. Signals, 1, 78–87 (1992).
  • 16) Shibata, K., Relationship between the ratio of the excreted by-products of niacin metabolism, N 1-methyl-2-pyridone-5-carboxamide+N 1-methyl-3-pyridone-4-carboxamide-N 1-methylnicotinamide and amino acid intake. Vitamins, 64, 1–18 (1990).
  • 17) Shibata, K., Effect of Protein-amino acids, lipid, and carbohydrate on the conversion ratio of tryptophan to niacin. Vitamins (Japan), 70, 369–382 (1996).
  • 18) Fukuwatari, T., Wada, H., Sasaki, R., and Shibata, K., Effect of excess nicotinamide administration on the urinary excretion of nicotinamide N-oxide and nicotinic acid by rats. Biosci. Biotechnol. Biochem., 68, 44–50 (2004).
  • 19) Ghafoorunissa, and Narasinga Rao, B. S., Effect of protein level in the diet on quinolinate phosphoribosyltransferase of rat liver. Life Sci., 15, 1597–1602 (1974).
  • 20) Satayana, U., and Narasinga Rao, B. S., Effect of diet restriction on some key enzymes on the tryptophan-NAD pathway in rats. J. Nutr., 107, 2213–2221 (1977).

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